Correlation between short- and mid-term hemoglobin A1c and glycemic control determined by continuous glucose monitoring

Huang, Jen Hung; Lin, Yung Kuo; Lee, Ting-I; Liu, Han–Wen; Chien, Yu Mei; Hsueh, Yu Chun; Chen, Yi Jen

doi:10.1186/s13098-021-00714-8

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…The HbA1c level provides insight into longterm glycemic control and correlates with various problems associated with diabetes. 36,37 Diabetic rats had significantly more glycosylated hemoglobin, indicating poor glycemic control. Nerolidol treatment significantly decreased HbA1c levels in diabetic rats compared to untreated diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic effects of nerolidol through promoting insulin receptor signaling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats

Jiang¹,

Zhang²

2022

Hum Exp Toxicol

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The present study was designed to investigate the antidiabetic effect of nerolidol on high-fat diet and streptozotocin-induced diabetic rats. Type 2 diabetes was induced in animals by feeding them a high-fat diet for 4 weeks and administering a single intraperitoneal dose of streptozotocin (35 mg/kg body weight). Diabetic rats were treated with nerolidol (25 mg/kg BW) for 28 days. Results showed that nerolidol treatment significantly reduced ( p < 0.05) the level of elevated glucose, glycosylated hemoglobin and improved ( p < 0.05) the body weight and insulin level. Nerolidol also considerably improved ( p < 0.05) the carbohydrate metabolic enzyme activities and increased the glycogen storage in the liver of diabetic rats. Increased serum triglycerides, total cholesterol (C), low-density lipoproteins-C and very low-density lipoproteins-C levels were significantly lowered ( p < 0.05), while reduction of serum high-density lipoprotein-C was alleviated after administration of nerolidol. In addition, nerolidol attenuated oxidative stress markers by significantly increasing ( p < 0.05) the levels of superoxide dismutase, catalase, reduced glutathione, and lowering ( p < 0.05) the level of thiobarbituric acid reactive substances, and lipid hydroperoxide. Similarly, nerolidol showed its pharmacological effects against hepatic markers via restoring ( p < 0.05) the alleviated level of alanine transaminase, aspartate aminotransferase, and alkaline phosphatase. Finally, it improved insulin-dependent glucose transport in skeletal muscle by enhancing and activating glucose transporter protein-4. These findings confirmed the antidiabetic potential of nerolidol in type 2 diabetic rats. This may be related to a high antioxidant capacity, the restoration of plasma insulin and lipid levels, and the activation of insulin signaling in STZ/HFD-induced diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic effects of nerolidol through promoting insulin receptor signaling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats

Jiang¹,

Zhang²

2022

Hum Exp Toxicol

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“…The use of continuous glucose monitors (CGMs) has resulted in the identification of glucose variability, that is, intraday fluctuations in blood glucose, as a risk factor for the development of cardiometabolic disease [ 7 ]. Greater glucose variability predicts increases in glycated hemoglobin (HbA 1c ) in both diabetic and nondiabetic populations [ 8 , 9 ]. Among persons with type 2 diabetes who maintain good glycemic control (HbA 1c ≤7.0%), greater glucose variability was an independent risk factor for coronary artery disease during a 10-year follow-up period [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Real-time Assessment of the Bidirectional Relationship Between Affective States and Glucose: Protocol for a 14-Day Observational Study

Rethorst¹,

Githinji²,

Seguin‐Fowler³

et al. 2023

JMIR Res Protoc

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Background Glucose variability increases cardiometabolic disease risk. While many factors can influence glucose levels, postprandial glucose response is the primary driver of glucose variability. Furthermore, affect may directly and indirectly impact glucose variability through its effect on eating behavior. Continuous glucose monitors (CGMs) facilitate the real-time evaluation of blood glucose, and ecological momentary assessment (EMA) can be used to assess affect in real time. Together, data collected from these sources provide the opportunity to further understand the role of affect in glucose levels. Objective This paper presents the protocol for a study that aims to (1) evaluate the feasibility and acceptability of using CGMs along with EMA in nondiabetic populations and (2) examine the bidirectional relationship between affect and glucose in nondiabetic adults with overweight or obesity using a CGM and EMA. Methods Eligibility criteria for the study include participants (1) aged 18 to 65 years old, (2) with a BMI of ≥25 kg/m2, (3) who are able to read and write in English, and (4) who own a smartphone. Individuals will be excluded if they (1) have type 1 or 2 diabetes or have any other condition that requires glucose monitoring, (2) are pregnant, (3) use any medications that have the potential to alter blood glucose levels or interfere with the glucose sensing process, or (4) have a diagnosed gastrointestinal condition or eating disorder. In a 14-day observational study, participants will wear a FreeStyle Libre Pro CGM sensor (Abbott) and will receive mobile phone–based EMA prompts 6 times per day (randomly within six 2-hour windows between 8 AM and 8 PM) to assess positive and negative affect. Participants will also wear a Fitbit Inspire 2 (Fitbit) to continuously monitor physical activity and sleep, which will be included as covariates in the analysis. Multilevel linear regression models will be used to evaluate the acute relationship between glucose level and affect. Results Recruitment started in October 2022 and is expected to be completed in March 2023. We will aim to recruit 100 participants. As of December 12, 2022, a total of 39 participants have been enrolled. Conclusions The results of this study will further elucidate the role of affect in glucose variability. By identifying affective states that may lead to glucose excursions, our findings could inform just-in-time behavioral interventions by indicating opportunities for intervention delivery. International Registered Report Identifier (IRRID) DERR1-10.2196/45104

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“…These processes are impaired through high levels of blood sugar. Therefore, dentists have to measure blood sugar levels (glycemic hemoglobin) to consider the severity of the disease (5,6) and create a premise for proper healing after invasive treatment.…”

Section: Introductionmentioning

confidence: 99%

Invasive dental treatment in patients with type 2 diabetes

Georgiev,

Balcheva

2021

Scripta Scientifica Medicinae Dentalis

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INTRODUCTION: Diabetes mellitus (DM) is disease resulting in high levels of blood sugar. As a general disease it affects the whole organism through the mechanisms of impaired insulin secretion, insulin resistance or both. However, dental practitioners need to perform invasive treatment in these patients in order to provide accurate dental treatment. AIM: The aim of this publication is to track the success rate of invasive treatment in diabetics. MATERIALS AND METHODS: During the research 125 invasive dental procedures were done on males and females in the age group 45-84 years. RESULTS: We achieved 98% success rate. CONCLUSION: Invasive dental treatment, including dental implants and surgeries, can be done in patients with DM with good and moderate control of the disease. It is mandatory to follow the protocols and the contemporary guidelines even more strictly than in the group of healthy patients.

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Correlation between short- and mid-term hemoglobin A1c and glycemic control determined by continuous glucose monitoring

Cited by 6 publications

References 39 publications

Antidiabetic effects of nerolidol through promoting insulin receptor signaling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats

Antidiabetic effects of nerolidol through promoting insulin receptor signaling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats

Real-time Assessment of the Bidirectional Relationship Between Affective States and Glucose: Protocol for a 14-Day Observational Study

Invasive dental treatment in patients with type 2 diabetes

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