Many countries advocate sports for all to cultivate people’s interest in sports. In cities, cross-industry alliances between sports and tourism are one of the common practices. The following two important issues need to be discussed, namely, what factors should be paid attention to in the development of sports tourism, and what are the mutual influential relationships among these factors. This study proposes a novel two-stage multi-criteria decision-making (MCDM) model to incorporate the concept of sustainable development into sports tourism. First, the Bayesian best–worst method (Bayesian BWM) is used to screen out important criteria. Bayesian BWM solves the problem of expert opinion integration of conventional BWM. It is based on the statistical probability to estimate the optimal group criteria weights. Secondly, the rough decision making trial and evaluation laboratory (rough DEMATEL) technique is used to map out complex influential relationships. The introduction of DEMATEL from the rough set theory has better practicality. In the calculation program, interval types are used to replace crisp values in order to retain more expert information. A city in central Taiwan was used to demonstrate the effectiveness of the model. The results show that the quality of urban security, government marketing, business sponsorship and mass transit planning are the most important criteria. In addition, in conjunction with local festivals is the most influential factor for the overall evaluation system.

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Fibroblast growth factor 23 (FGF23), elevated in chronic renal failure, increases atrial arrhythmogenesis and dysregulates calcium homeostasis. Late sodium currents (INa-Late) critically induces ectopic activity of pulmoanry vein (the most important atrial fibrillation trigger). This study was to investigate whether FGF23 activates the INa-Late leading to calcium dysregulation and increases PV arrhythmogenesis. Patch clamp, western blot, and confocal microscopy were used to evaluate the electrical activities, calcium homeostasis, and mitochondrial reactive oxygen species (ROS) in PV cardiomyocytes with or without FGF23 (0.1 or 1 ng/mL) incubation for 4~6 h. Compared to the control, FGF23 (1 ng/mL, but not 0.1 ng/mL)-treated PV cardiomyocytes had a faster beating rate. FGF23 (1 ng/mL)-treated PV cardiomyocytes had larger INa-Late, calcium transients, and mitochondrial ROS than controls. However, ranolazine (an inhibitor of INa-Late) attenuated FGF23 (1 ng/mL)-increased beating rates, calcium transients and mitochondrial ROS. FGF23 (1 ng/mL)-treated PV cardiomyocytes exhibited larger phosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII). Chelerythrine chloride (an inhibitor of protein kinase C) decreased INa-Late in FGF23 (1 ng/mL)-treated PV cardiomyocytes. However, KN93 (a selective CaMKII blocker) decreased INa-Late in control and FGF23 (1 ng/mL)-treated PV cardiomyocytes to a similar extent. In conclusion, FGF23 increased PV arrhythmogenesis through sodium and calcium dysregulation by acting protein kinase C signaling.

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