Correlation between Serum Resistin Level and Adiposity in Obese Individuals

Azuma, Koichiro; Katsukawa, Fuminori; Oguchi, Shuji; Murata, Mitsuru; Yamazaki, Hajime; Shimada, Akira; Saruta, Takao

doi:10.1038/oby.2003.137

Cited by 323 publications

(262 citation statements)

References 18 publications

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“…In contrast to some studies in adults, [6][7][8]18 the resistin levels did not differ between obese and lean children. The sample sizes in the studies in adults were similar 6 or smaller 7,8,18 as compared to our study.…”

Section: Discussioncontrasting

confidence: 95%

“…The sample sizes in the studies in adults were similar 6 or smaller 7,8,18 as compared to our study. A too small sample size in our study to detect significant differences was excluded by a power analysis.…”

Section: Discussionsupporting

confidence: 49%

“…We performed a power calculation based on the published differences in resistin levels between obese and lean adults. 18 Azuma et al 18 demonstrated a 50% difference of resistin levels between these two groups. The required sample size is 26 based on these data estimated for a significance level of 0.05 and a power of 0.9.…”

Section: Methodsmentioning

confidence: 97%

“…Despite the great number of cross-sectional studies, there are only few longitudinal studies in adulthood with small numbers of subjects concerning resistin levels in obesity with contradictory results. Two longitudinal analyses revealed changes in serum resistin to be positively correlated with changes in fat mass or weight status 18,19 and mean insulin, 18 while other studies reported no changes of resistin in weight loss. 13,16,20 As a result of these controversial findings, the small number of longitudinal data and, most importantly, the lack of studies concerning resistin levels in children, we studied resistin serum levels in obese and lean children in relation to age, gender, puberty, and insulin resistance and measured resistin concentrations before and after weight loss.…”

Section: Introductionmentioning

confidence: 90%

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Resistin concentrations before and after weight loss in obese children

et al. 2005

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Objective: The influences of gender, puberty, and obesity on resistin levels and the longitudinal relationships between insulin resistance, weight loss, and resistin have not yet been studied in childhood. Methods: Age, pubertal stage, gender, weight status (standard deviation score-body mass index (SDS-BMI)), resistin levels, and insulin resistance index calculated by homeostasis model assessment (HOMA) were evaluated in 63 obese children and compared to 36 lean children of same age, gender, and pubertal stage. Furthermore, we analyzed the changes of weight status (SDS-BMI, percentage body fat based on skinfold measurements), waist-to-hip ratio, resistin, and HOMA over a 1-year period in 38 obese children. Results: The resistin levels did not significantly (P ¼ 0.079) differ between obese (median resistin 8.7 ng/ml) and lean children (median resistin 9.7 ng/ml). Resistin concentrations were independent of age and pubertal stage, but girls demonstrated significantly higher resistin levels than boys (P ¼ 0.021). There were no significant correlations between changes of resistin and changes of SDS-BMI (r ¼ 0.14, P ¼ 0.198), changes of percentage body fat (r ¼ À0.01, P ¼ 0.466), changes of waist-to-hip ratio (r ¼ 0.17, P ¼ 0.141), and changes of insulin resistance index (r ¼ 0.01, P ¼ 0.472) over the 1-year period. The weight loss of X0.5 SDS-BMI in 16 children was associated with a significant decrease in HOMA (P ¼ 0.030), while there was no significant change in resistin levels (P ¼ 0.878). Conclusions: Girls demonstrated higher resistin concentrations than boys. Our data do not support a relationship between resistin, insulin resistance index, and weight status in childhood.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionsupporting

confidence: 49%

Section: Methodsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 90%

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Resistin concentrations before and after weight loss in obese children

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“…61 Resistin is positively related to the percentage of body fat and BMI. 62 Patients with type 2 diabetes treated with thiazolidinedione showed a significant reduction in plasma resistin concentrations. 63 In this latter study, the decrease in plasma resistin was correlated with a decrease in hepatic fat content and improvement in hepatic insulin sensitivity.…”

Section: Resistinmentioning

confidence: 98%

The entero-insular axis and adipose tissue-related factors in the prediction of weight gain in humans

2006

Int J Obes

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Obesity has now reached epidemic proportions. Epidemiological studies in the past decades have shown that adults gain weight and adiposity from the early twenties until their sixties. In the paediatric population, growing numbers of children and adolescents put on unhealthy weight. Many environmental, socio-economical and biological determinants that predispose to weight gain have been identified thus far. The aim of the present review is to summarize the current knowledge on the role of the circulating levels of adipokines and other entero-insular hormones and biological markers of obesity to predict weight gain in humans. The review focuses on relationship between hormonal and biochemical markers (insulin, insulin-like growth factors, gastrointestinal hormones, leptin, adiponectin, resistin, inflammatory proteins and cytokines) and weight gain in prospective studies. The complex relationships displayed by these hormonal factors with future weight gain in humans are critically reviewed and integrative models are proposed. Overall, most of the studies reported to date made adjustments for baseline body mass index but failed to consider dietary intake and physical activity as confounding factors. Outstanding questions are raised and new directions for future prospective studies are proposed in order to improve our understanding of the role of biological determinants of energy balance and development of obesity in humans.

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Roles of Gastrointestinal and Adipose Tissue Peptides in Childhood Obesity and Changes After Weight Loss Due to Lifestyle Intervention

Roth

Reinehr

2010

Arch Pediatr Adolesc Med

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hildhood obesity is a global epidemic and associated with an increased risk of hypertension, diabetes mellitus, and coronary heart disease, in addition to psychological disorders. Interventions such as bariatric surgery are highly invasive and lifestyle modifications are often unsuccessful because of disturbed perceptions of satiety. New signaling peptides discovered in recent years that are produced in peripheral tissues such as the gut, adipose tissue, and pancreas communicate with brain centers of energy homeostasis, such as the hypothalamus and hindbrain. This review discusses the major known gut-and adipose tissuederived hormones involved in the regulation of food intake and energy homeostasis and their serum levels in childhood obesity before and after weight loss as well as their relationship to consequences of obesity. Since most of the changes of gastrointestinal hormones and adipokines normalize in weight loss, pharmacological interventions based on these hormones will likely not solve the obesity epidemic in childhood. However, a better understanding of the pathways of body weightand food intake-regulating gut-and adipose tissue-derived hormones will help to find new strategies to treat obesity and its consequences.

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Correlation between Serum Resistin Level and Adiposity in Obese Individuals

Cited by 323 publications

References 18 publications

Resistin concentrations before and after weight loss in obese children

Resistin concentrations before and after weight loss in obese children

The entero-insular axis and adipose tissue-related factors in the prediction of weight gain in humans

Roles of Gastrointestinal and Adipose Tissue Peptides in Childhood Obesity and Changes After Weight Loss Due to Lifestyle Intervention

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