Correlation between Serum Creatine Phosphokinase and Severity of Acute Organophosphorus Poisoning: A Prospective Clinical Study (2012-2013

Abstract

Organophosphorus (OP)

Serum Creatine Phosphokinase Level- As a Severity Marker in Acute Organophosphate Poisoning

“…Most patients were from rural area (65%) with 46% patient living below poverty line. These findings were similar to studies conducted by Bhattacharya et al, 14 Sen R et al 22 and Reddi et al 23 Most common mode was suicidal (88%) and most common occupation was student (30%) followed by farmer (22%) which is similar to studies conducted by Dubey et al, 21 Nermeen et al 20 Chlorpyrifos (28%) was most common compound ( Figure 1) involved followed by Phorate (23%) which is commonly used pesticide in our area. However similar trend was noted in study of Bhattacharya et al 14 and Nagarajan et al 24 Vomiting (86%), salivation (71%) were most common symptoms ( Figure 2) while miosis (88%), bradycardia (62%) were most common sign (Figure 2) similar to study of Agrawal S et al 19 Creatine Phosphokinase, an enzyme which is expected to rise in patients with OP compound poisoning due to muscle necrosis.…”

“…18 Estimation of CPK is economical and levels are increased both in acute as well as in intermediate syndrome and can be used as a low budget, easily available prognostic marker for acute organophosphorus poisoning. 14,19,20 Aims and Objectives…”

Study of Levels of Serum Creatine Phosphokinase and Liver Enzymes as a Prognostic Indicators in Acute Organophosphorus Poisoning

“…Majority of the patients in our study were females which accounting for 51.3% 41 cases and males were 39 cases 48.8%. This is consistent with Murat S et al [11] study with female predominance and also in the study done by Hassan NAM et al [10] with 51.7% were males and 48.3% were males. But in Bhattacharyya et al [8] study 66.6% were males and 33.3% were females.…”

“…This is consistent with the study done by Bhattacharyya et al [8] which showed that most commonest age group is 21-30 years and also in Mcihammet G et al [9]. But in the study done by Hassan NAM et al [10] the common age group is 11-20 years. As we can see the most common group of affected individuals are among youngsters and the reason may be because these individuals are vulnerable to various emotion conflicts that occur during this phase of life.…”

“…Estimation of serum creatine kinase and liver enzymes like SGOT and SGPT, serum amylase has become one of the new emerging options in predicting the severity of OP poisoning [6]. Estimation of Creatine Phosphokinase (CPK) is easy and levels are increased both in acute phase and in intermediate syndrome due to muscle fibre necrosis.…”