Study of Levels of Serum Creatine Phosphokinase and Liver Enzymes as a Prognostic Indicators in Acute Organophosphorus Poisoning

Kollur, Banashankari S; Mulimani, Mallanna S.

doi:10.5455/ijcbr.2018.41.12

Cited by 2 publications

(1 citation statement)

References 6 publications

(11 reference statements)

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“…Henceforth, the estimation of acetylcholinesterase and butyrylcholinesterase are validated screening tools for the diagnosis and prognosis of OP poisoning 19 . Similarly, another potential prognostic indicator in OP poisoning is creatine phosphokinase levels 20 , 21 . The serum creatine phosphokinase levels could rise due to rhabdomyolysis or intermediate syndrome of OP poisoning 22 .…”

Section: Discussionmentioning

confidence: 99%

The relationship of serum amylase levels in acute organophosphorus poisoning with its clinical severity and outcome: a cross-sectional study

Subedi

Raut²,

Joshi

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: There are limited literatures studying the pancreatic involvement in organophosphate (OP) poisoning using biochemical means. This study focused on assessing the type of OP poisoning and determining the association of serum amylase levels with the patient’s presentation and outcome. Materials and methods: A cross-sectional study was carried out in the Maharajgunj Medical Campus, Tribhuwan University Teaching Hospital, Kathmandu, Nepal, after ethical approval [Ref: IRB/308 (6-11-E)]. We collected data from 172 participants with OP poisoning over the period of 2 years using nonprobability purposive sampling method. All patients with age group 16–75 years having a history of OP poisoning within the previous 24 h with clinical features and physical evidence of poisoning were included in the study. Those participants with indications of exposure to an entirely different poisons, poisoning with multiple poisons, OP poisoning along with alcohol, chronic alcoholics, comorbid conditions, taking drugs that could affect serum amylase levels (azathioprine, thiazides, furosemide, etc.), and/or treated in other hospitals after poisoning were excluded from the study. Appropriate statistical calculations were made using the statistical package for social sciences (SPSS), version 21. The P -value of less than 0.05 was considered statistically significant. Results: Metacid (53.5%, 92) was the most common OP poison. There were significantly higher mean values of serum amylase levels either within 12 h of exposure (468.60 vs. 135.4 IU/ml, P <0.001) or after 12 h of exposure (152.0 vs. 58.9 IU/ml, P <0.001) in dead participants than alive ones. The participants with initial and after 12 h of exposure-serum amylase level 100 or more IU/ml had more than two-fold and 18-fold higher odds of severe/life-threatening severity (odds ratio=2.40, 95% CI: 1.28–4.52, P =0.007 and odds ratio=18.67, 95% CI: 8.02–43.47, P <0.001) respectively than those with less than 100 IU/ml. Conclusions: The clinical severity of OP poisoning is directly related to serum amylase levels. Importantly, higher mean values of serum amylase levels were depicted in those participants with OP poisoning culminating to death. Thus, serum amylase level could be one of the easy measurable prognostic marker of OP poisonings.

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Section: Discussionmentioning

confidence: 99%

The relationship of serum amylase levels in acute organophosphorus poisoning with its clinical severity and outcome: a cross-sectional study

Subedi

Raut²,

Joshi

et al. 2023

Annals of Medicine &Amp; Surgery

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Study of Levels of Creatine Phosphokinase and Lactate Dehydrogenase as Prognostic Markers in Acute Organophosphorus Poisoning

Parate,

Madavi,

Parate

2024

VJIM

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Objectives: Organophosphorus compound (OPC) poisoning is primarily a problem in developing countries. Its widespread use and easy availability have increased the likelihood of poisoning with these compounds. Serum cholinesterase levels are easier to estimate and usually depressed after organophosphorus (OP) poisoning. Peradeniya OP poisoning scale has not been studied much in the Indian scenario. It could be a simple and effective system to determine the need for ventilatory support early on in the course. Hence, this study was undertaken to assess the severity of OPC poisoning clinically using Peradeniya scoring and by estimating creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) levels. Material and Methods: A prospective observational study was performed among 100 cases of OP poisoning from January 2021 to October 2022. On patient’s fulling, inclusion criteria were investigated with serum acetylcholinesterase at the time of admission, and periodic estimation of serum CPK and serum LDH was done on the day of admission and then on day three and day 5 of admission Results: The CPK and LDH levels were significantly elevated in patients who developed respiratory failure and thus strongly correlated with clinical severity Conclusion: Serum CPK and LDH show a strong degree of positive correlation with the severity of poisoning and can be used as a predictor of outcome in OP poisoning.

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Study of Levels of Serum Creatine Phosphokinase and Liver Enzymes as a Prognostic Indicators in Acute Organophosphorus Poisoning

Cited by 2 publications

References 6 publications

The relationship of serum amylase levels in acute organophosphorus poisoning with its clinical severity and outcome: a cross-sectional study

The relationship of serum amylase levels in acute organophosphorus poisoning with its clinical severity and outcome: a cross-sectional study

Study of Levels of Creatine Phosphokinase and Lactate Dehydrogenase as Prognostic Markers in Acute Organophosphorus Poisoning

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