Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri

Patterson, Donald; Ll, Needham; Pirkle, J. L.; Roberts, D. W.; Bagby, John R.; Garrett, Woodrow; Andrews, John S.; Falk, Henry; Bernert, John T.; Sampson, Eric J.; Houk, Vernon N.

doi:10.1007/bf01056017

Cited by 135 publications

(51 citation statements)

References 17 publications

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“…Based on the conclusions of this modeling and analysis, we make predictions regarding future body burden trends and provide perspectives on the effects of future changes in intake levels (e.g., via new control measures ) on general -population body burdens. Patterson et al ( 1988 ), human adipose tissue levels of TCDD on a lipid -adjusted basis are generally comparable to serum lipid -adjusted levels. Therefore, values reported in adipose tissue on a lipid -adjusted basis were compared directly with serum lipid -level measurements; values reported in adipose tissue on a whole -weight basis were adjusted using an assumption of 80% lipid in adipose tissue (Patterson et al, 1988 ) for comparison to both lipid -adjusted adipose tissue levels and serum lipid levels.…”

Section: Introductionmentioning

confidence: 87%

“…Patterson et al ( 1988 ), human adipose tissue levels of TCDD on a lipid -adjusted basis are generally comparable to serum lipid -adjusted levels. Therefore, values reported in adipose tissue on a lipid -adjusted basis were compared directly with serum lipid -level measurements; values reported in adipose tissue on a whole -weight basis were adjusted using an assumption of 80% lipid in adipose tissue (Patterson et al, 1988 ) for comparison to both lipid -adjusted adipose tissue levels and serum lipid levels. We extracted from each study the mean, minimum, and maximum lipid -adjusted TCDD levels; the average age and age range of persons sampled; and the year( s) of sampling.…”

Section: Introductionmentioning

confidence: 87%

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Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels

Aylward

Hays

2002

J Expo Sci Environ Epidemiol

105

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Data on lipid levels of 2, 3,7, in the general population in the United States, Canada, Germany, and France over the past 30 years were compiled from the literature. Mean lipid levels of TCDD exhibited a steady decrease by nearly a factor of 10 over this time period, with lipid -adjusted TCDD levels in 2000 about 2 parts per trillion ( ppt ). Pharmacokinetic modeling using a one -compartment model indicated that absorbed intake levels of TCDD must have decreased by more than 95% from levels in 1972 to result in the observed decrease in human lipid levels, with the bulk of this decrease occurring before 1980. Based on this modeling and the pharmacokinetic properties of TCDD in humans, we conclude that mean levels of TCDD in the general population are likely to decrease further over the next 15 years, to between 0.5 and 1 ppt, even if intake levels do not decrease further. Fewer data over a shorter time period are available for other dioxin and furan congeners in human lipid, but these data indicate substantial decreases as well, with general population TEQ lipid levels currently at least fourfold lower than in 1970 and still decreasing. Food sampling data are limited, but support these trends.

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Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 87%

Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels

Aylward

Hays

2002

J Expo Sci Environ Epidemiol

105

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“…As equilibrium states are reached, the chemicals redistribute, and chemicals with high lipid solubility concentrate in tissue with higher fat content, such as adipose tissue in the brain, liver, kidney, and in the case of lactating women, the mammary gland. Patterson et al 19 reported that average levels of TCDD were 158 times higher in adipose tissue than in serum, but when each matrix was adjusted for its lipid content, the levels of TCDD were comparable in each matrix. Thus, tissue perfusion and the lipid partition coefficient play important roles in the distribution of chemicals in the body.…”

Section: Breastfeeding and Pollutant Pharmacokineticsmentioning

confidence: 99%

Human Breast Milk and Xenoestrogen Exposure: A Possible Impact on Human Health

et al. 2004

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“…The chlorinated pesticides fixations can then be passed on as nanoe-gram per gram (µg/ml) lipid (15). .…”

Section: Discussionmentioning

confidence: 99%

Evaluation the Level of Dieldrin and Heptachlor in Iraqi People

Jawad

2017

JNUS

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Organochlorine pesticides for whatever length of time that been extensively utilized as a part of farming and in public health as highly effective pest control agents.They are lipophelic and have drawn out a half-existences of years to decades; thus, they amass in human fat tessues and a can bring about endless poisonous quality after long term exposure.To detect and measure the concentrations of organochlorine pesticides, (Dieldrin and Heptachlor) in serum and fatty tissue samples and studies their correlation with lipids in order to reveal the need. for human monitoring.The study was conducted on 50 samples of blood and fatty tissues to determine their lipid concentrations and detect metabolites of organochlorine pesticides and asses their1correlations using HPLC.The study observed that there were raised serum concentrations of lipids which were positively corresponded with lifted serum convergences of Dieldrin and Heptachlor pesticides.Mean serum concentrations of triglycerides was inside "normal" range while mean serum of aggregate cholesterol was hoisted above ordinary range. Rate of grouping of lipid to serum Dieldrin was higher than that of Heptachlor in living subjects.

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Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri

Cited by 135 publications

References 17 publications

Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels

Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels

Human Breast Milk and Xenoestrogen Exposure: A Possible Impact on Human Health

Evaluation the Level of Dieldrin and Heptachlor in Iraqi People

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