Correlation between sarcopenia and arteriosclerosis in elderly community dwellers: A multicenter study

Abstract

Background Evidence suggests that arteriosclerosis and sarcopenia (decreased muscle mass) share some of their many causes. However, after controlling for confounding factors, it is unclear whether the presence of arteriosclerosis correlates with sarcopenia. The aim of this paper is to explore whether sarcopenia is associated with arteriosclerosis. Methods A total of 2511 elderly subjects from six Chinese community health service centers in Anhui province were surveyed through an e-health promotion system to collect basic data and measurements of brachial-ankle pulse wave (baPWV), body composition, and handgrip strength (HGS). Pearson's correlation and binary logistic regression analyses were performed to identify associations between sarcopenia and high baPWV. Results The prevalence rates of sarcopenia were 12.9% in men and 15.3% in women according to the 2019 standard of Asian Working Group for Sarcopenia. Among subjects with high baPWV, the proportion of sarcopenia was higher compared to those with normal baPWV (men: 17.7% vs 3.7%; women: 20.4% vs 4.9%, both P < 0.001). Binary logistic regression analysis revealed that sarcopenia was associated with high baPWV (P < 0.0001, odds ratio 1.619) after adjusting for confounding factors. HGS slightly and negatively correlated with baPWV (-0.19 in men and − 0.18 in women). Conclusions The intertwined pathophysiological mechanisms shared by arteriosclerosis and sarcopenia are potential targets for future interventions to reduce morbimortality in subjects with both disorders. Upcoming prospective studies and clinical trials are expected to advance these findings.

Relationship Between Arteriosclerosis and Body Composition in Patients with type 2 Diabetes Mellitus: Cross-Sectional Study

“…Moreover, for the correlations between ba-PWV and lower limb circumferences, the correlation coe cients were higher for values related to maximum lower limb circumference than for those related to thigh circumference, with TRSC% being the highest. Lower limb circumference is also used as an indicator of sarcopenia [21], and sarcopenia is a risk factor for arteriosclerosis [22]. A decline in muscle mass has been reported to reduce antiin ammatory myokine secretion and cause arteriosclerosis [23].…”

The relationship of dietary total antioxidant capacity with sarcopenia and cardiometabolic biomarkers in type 2 diabetes patients

“…Sarcopenia is an involuntary resorption of skeletal muscle with decreased muscle strength and function (Sun et al, 2021 ), which has recently been considered as a new complication in diabetic patients (Cruz‐Jentoft et al, 2019 ; Sluijs et al, 2015 ; Yasemin et al, 2019 ). The pathogenesis of sarcopenia is complicated and associated with aging, sedentary lifestyle, nutritional factors, increased production of reactive oxygen species, increased levels of proinflammatory cytokines, hormonal changes, and decreased neuromuscular function (Chen et al, 2020 ; Tan et al, 2021 ; Trierweiler et al, 2018 ).…”