Correlation between salivary immunoglobulin A and interleukin-1beta in smokers with dental caries

Al-ibraheem, Jaber; Zyara, Yassir; Al-Quraine, Nibrass; Abdulridha, Wasna’a M.

doi:10.12688/f1000research.129649.2

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Известно, что количество иммуноглобулинов слюны может увеличиваться при развитии воспаления. Преобладающим иммуноглобулином слизистых оболочек является иммуноглобулин А (IgA), который является основным специфическим защитным гликопротеином для тканей ротовой полости [19,20]. Антитела класса IgG, IgM (иммуноглобулины G, M) обладают провоспалительными свойствами и могут приобретать иммунопатологическую роль, когда невозможна элиминация антигена [21].…”

Section: Introductionunclassified

Efficacy of Various Regimens of Inhibitor-Protected Penicillins on the Basis of Immunospecific Mixed Saliva Proteins in Patients after Dental Implantation: a Randomized Uncontrolled Trial

Gabidullina,

Tsitsiashvili,

Zaborovsky

et al. 2023

Kuban. nauсh. med. vestnik

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Background. The available comparative studies on issues of choosing antibiotic regimen in dental implantation are often observational and describe only visible postoperative signs. More objective assessment of postoperative period and comparison of approaches requires laboratory tests. One of the methods to be used at a dental appointment is to study examination of the biochemical properties of saliva.Objective. To carry out comparative evaluation of single and prolonged regimens of amoxicillin/clavulanate administration after dental implantation indicated by nonspecific immunity in mixed saliva.Methods. A randomized uncontrolled trial of 30 partially edentulous patients was conducted. The clinical phase of the study was performed at the Department of Propaedeutics of Surgical Dentistry, MSUMD; the laboratory phase — at the Pharmacology and Biological Chemistry Departments, MSUMD, in 2021–2022. The study included patients aged 18 to 75 years, anatomically suitable for dental implant placement. Patients with somatic diseases in the decompensation stage were excluded from the study. Patients were randomized into 2 groups. The group 1 was prescribed to take amoxicillin/clavulanate pills (875+125 mg) 30 minutes before surgery. The group 2 was to take amoxicillin/clavulanate (875+125 mg) 30 minutes before surgery and then 1 pill of Amoxicillin/ Clavulanate (500+125 mg) 2 times a day for 7 days after surgery. To evaluate the efficacy of the applied antibiotic therapy, unstimulated mixed saliva was collected from all patients on an empty stomach, 1 ml before surgery and on the third day after surgery. The amount of immunoglobulins of G, M, A classes (mg/l) and б-amylase activity (IU/l) were determined spectrophotometrically in the saliva samples. Statistical processing of laboratory data was performed using Welch's t-test by means of Statistica 10 Pro (StatSoft, USA). Intergroup and intragroup differences were considered significant at p ≤ 0.05.Results. Based on the saliva proteins examined, the most pronounced difference between the patient groups was obtained for IgA. For other studied parameters of saliva, no significant difference between the groups was obtained on the third day after the surgery. However, despite the absence of a statistical difference, a tendency to a stronger increase in the amount of IgA, G, IgM, salivary amylase activity was noted for all indicators; moreover, a high correlation between immunoglobulins of class A, G, immunoglobulins of class G, M, and immunoglobulins of class A, M was revealed.Conclusion. Among patients with the prolonged regimen, the groups did not differ significantly in such saliva parameters as immunoglobulins G and M and salivary б-amylase activity, however, a tendency to a stronger increase of the mentioned immunoglobulins in the saliva of group 1 patients was revealed. The most significant difference was recorded for immunoglobulin A in saliva, the amount of which was significantly lower in the group of prolonged antibiotic administration (p < 0.05).

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Section: Introductionunclassified

Efficacy of Various Regimens of Inhibitor-Protected Penicillins on the Basis of Immunospecific Mixed Saliva Proteins in Patients after Dental Implantation: a Randomized Uncontrolled Trial

Gabidullina,

Tsitsiashvili,

Zaborovsky

et al. 2023

Kuban. nauсh. med. vestnik

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A double‐blind randomized clinical trial of inflammatory cytokine and pepsin levels in the saliva of patients with voice prostheses

Żurek,

Czesak,

Czerwińska

et al. 2024

Head & Neck

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BackgroundTracheoesophageal speech is one of the most effective method used for voice rehabilitation after laryngectomy. The main limitation is the need for periodic voice prothesis (VP) replacements. The process of developing VP usage complications is still unexplored. The aim of this study was to assess the level of cytokines (IL‐1β, IL‐6, IL‐8, IL‐10, TNFα) and pepsin in saliva as potential factors reducing VP longevity.MethodsProspective double‐blind randomized clinical trial was conducted (NCT04268459). Patients were randomly divided into two groups depending on VP replacement regimen (regular—every 3 months, or irregular—when complications occur). Levels of IL‐1β, IL‐6, IL‐8, IL‐10, TNFα, and pepsin in saliva samples (fasting and after eating) of laryngectomized patients were measured using ELISA tests.ResultsFifty‐two patients (26 in both groups) with control group (7 patients) participated in the study. The level of IL‐1β, IL‐6, IL‐8, IL‐10, TNFα, and pepsin did not differ according to regularity of VP replacements (p = 0.301–0.801). IL‐6 levels were significantly higher when VP complications occurs (p = 0.012).ConclusionsThe saliva components were not significantly different depending on the frequency of VP replacements. IL‐6 plays an important role in the development of VP use complications.

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Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis

Alarcón-Sánchez,

Becerra-Ruiz,

Avetisyan

et al. 2024

BMC Oral Health

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Background Cytokines play an important role in the immunopathogenesis of dental caries. A systematic review and meta-analysis was carried out with the following three objectives: 1)To deepen and discuss through a comprehensive analysis of the literature the effects of dental caries on the activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults, 2)To compare the levels of this cytokines in saliva of the exposure group (moderate-severe dental caries) with the control group (caries-free or mild dental caries), and 3)To determine whether the levels of these cytokines could be used as a complementary clinical diagnostic tool to assess the severity of dental caries. Methods The protocol followed PRISMA and Cochrane guidelines and was registered in the Open Science Framework (OSF): https://doi.org/10.17605/OSF.IO/MF74V. A digital search was performed in PubMed/MEDLINE, Cochrane, Scopus, and Google Schoolar databases from February 15th, 2012, to January 13th, 2024. The methodological validity of the selected studies was assessed using Joanna Briggs Institute (JBI) tool. A meta-analysis was performed using a random-effects model to evaluate the association between dental caries/health, and the concentration of TNF-α, IL-6 and IL-8. Results The search strategy provided a total of 126 articles, of which 15 investigations met the inclusion criteria. The total number of patients studied was 1,148, of which 743 represented the case/exposure group, and 405 represented the control group. The age of the patients ranged from 3 to 25 years. IL-6 was the most prevalent cytokine in the saliva of children and young adults with active dental caries. The meta-analysis revealed that there are significant differences between the levels of IL-6 and TNF-α in saliva of children with active dental caries compared to their control groups. Conclusions The findings suggest that IL-6 and TNF-α levels may have potential as complementary biomarkers for assessing dental caries severity. However, further research is needed to validate these findings in larger and more diverse populations before clinical application.

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Correlation between salivary immunoglobulin A and interleukin-1beta in smokers with dental caries

Cited by 3 publications

References 30 publications

Efficacy of Various Regimens of Inhibitor-Protected Penicillins on the Basis of Immunospecific Mixed Saliva Proteins in Patients after Dental Implantation: a Randomized Uncontrolled Trial

Efficacy of Various Regimens of Inhibitor-Protected Penicillins on the Basis of Immunospecific Mixed Saliva Proteins in Patients after Dental Implantation: a Randomized Uncontrolled Trial

A double‐blind randomized clinical trial of inflammatory cytokine and pepsin levels in the saliva of patients with voice prostheses

Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis

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