Correlation between recurrence of anorectal condyloma acuminatum and human papilloma virus subtype

Kim, Jeong-ki; Park, Yong-Gum; Kim, Beom Gyu

doi:10.1007/s13258-022-01221-4

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…CA, a proliferative disease caused by HPV infection, usually presents no special clinical symptoms, and only a small proportion of patients show clinical and histopathological damage (17). On the other hand, CA has the characteristics of a long incubation period and repeated attacks (18), which requires clinical trials to find an early diagnosis and condition evaluation index suitable for CA as soon as possible to provide a more reliable guarantee for patients' health. miR-125b has not only been confirmed to have a close relationship with HPV infection (19,20), but also has the function of regulating the immune function of cardiomyocytes (21).…”

Section: Discussionmentioning

confidence: 99%

Correlation of miR-125b with Treg/Th17 cell imbalance in Condyloma acuminatum and its regulation on autophagy of keratinocytes

Ma¹

2023

Cell Mol Biol (Noisy-le-grand)

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Section: Discussionmentioning

confidence: 99%

Correlation of miR-125b with Treg/Th17 cell imbalance in Condyloma acuminatum and its regulation on autophagy of keratinocytes

Ma¹

2023

Cell Mol Biol (Noisy-le-grand)

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“…After the virus enters the epidermis, it forms a latent infection in the basal layer of keratinocytes. The replication process of infected epidermis allows HPV to enter the nucleus, replicate and spread with cell division, and form warts [ 20 ]. As CA infection has an incubation period of 1–6 months [ 21 ], when a sexual partner has a skin rash or is accompanied by HPV infection, he should see a doctor in time.…”

Section: Discussionmentioning

confidence: 99%

Establishing a prediction model for recurrence of condyloma acuminatum

et al. 2022

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We collected the clinical data of 156 patients diagnosed with condyloma acuminatum (CA), including age, gender, marriage, education level, stay up late, smoking, drinking, number of sexual partners, HPV infection status of sexual partners, genitourinary and anal diseases, condom use, other diseases of HPV infection, location and number of warts, HPV typing, etc. Analyze the risk factors affecting the recurrence of CA, explore the influencing factors and independent influencing factors of CA recurrence, establish the prediction model of CA recurrence, and evaluate its prediction value. Univariate analysis showed that stay up late, HPV infection status of sexual partners, urogenital diseases, condom use, other diseases of HPV infection and the number of CA were the influencing factors of CA recurrence. Multivariate analysis showed that condom use (OR = 0.166), HPV infection status of sexual partners (OR = 4.848), number of warts (OR = 1.212) and urogenital diseases (OR = 3.179) were independent factors affecting the recurrence of CA (P < 0.05). Therefore, the prediction model of CA recurrence can be established, and the area under the curve AUC of the prediction model was calculated to be 0.867 (95% CI 0.812–0.923). The model established in this study has certain prediction value for the recurrence of CA and can be used to preliminarily predict the recurrence of CA.

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“…30 Another study by Kim et al also suggest a significant association of high-risk HPV subtypes with anorectal CA. 31…”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy in the treatment of condyloma acuminata: A systematic review of clinical trials

et al. 2022

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Introduction Condylomata acuminata (CA) is a sexually transmitted infection with a high prevalence associated with psychosexual morbidity in both men and women of various age. Up to now, treatment modalities yield low clearance and recurrence rate (RR) and are also deemed low quality evidence-wise. Photodynamic therapy (PDT) is a novel and promising therapy to effectively cure and prevent CA recurrence. Method This systematic review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and registered to the International Prospective Register of Systematic Review (PROSPERO) (CRD42022332760). Results Ten studies were included in this systematic review. A significant value of complete response (CR) ranging from 63–100% in patients with genital warts after receiving several sessions of PDT. A relatively low recurrence rate was seen in all 10 studies, with an RR of less than 17%. Quality assessment of included studies reported mostly high-quality research. Conclusions PDT therapy resulted in a higher CR with significantly lower RR compared to other therapies. Thus, PDT can be an alternative treatment of CA with low RR and minimal side effects. Additional research, especially randomized clinical trials in various countries, is needed to further substantiate this treatment and formulate definitive protocols.

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Correlation between recurrence of anorectal condyloma acuminatum and human papilloma virus subtype

Cited by 4 publications

References 20 publications

Correlation of miR-125b with Treg/Th17 cell imbalance in Condyloma acuminatum and its regulation on autophagy of keratinocytes

Correlation of miR-125b with Treg/Th17 cell imbalance in Condyloma acuminatum and its regulation on autophagy of keratinocytes

Establishing a prediction model for recurrence of condyloma acuminatum

Photodynamic therapy in the treatment of condyloma acuminata: A systematic review of clinical trials

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