Establishing a prediction model for recurrence of condyloma acuminatum

Abstract

We collected the clinical data of 156 patients diagnosed with condyloma acuminatum (CA), including age, gender, marriage, education level, stay up late, smoking, drinking, number of sexual partners, HPV infection status of sexual partners, genitourinary and anal diseases, condom use, other diseases of HPV infection, location and number of warts, HPV typing, etc. Analyze the risk factors affecting the recurrence of CA, explore the influencing factors and independent influencing factors of CA recurrence, establish the prediction model of CA recurrence, and evaluate its prediction value. Univariate analysis showed that stay up late, HPV infection status of sexual partners, urogenital diseases, condom use, other diseases of HPV infection and the number of CA were the influencing factors of CA recurrence. Multivariate analysis showed that condom use (OR = 0.166), HPV infection status of sexual partners (OR = 4.848), number of warts (OR = 1.212) and urogenital diseases (OR = 3.179) were independent factors affecting the recurrence of CA (P < 0.05). Therefore, the prediction model of CA recurrence can be established, and the area under the curve AUC of the prediction model was calculated to be 0.867 (95% CI 0.812–0.923). The model established in this study has certain prediction value for the recurrence of CA and can be used to preliminarily predict the recurrence of CA.

The Combination Therapy of Condyloma Acuminata Patient with Diabetes Mellitus: Case Report

“…Relapses often occur 3 months after treatment. [6,8] In this case, there was no recurrence after a 3-month followup.…”

“…A study in China found that 59.6% of cases were in males, 32% were over 50 years old, and 48.7% were married. [8] In this case, the patient is a 53-year-old married male. Transmission of condyloma acuminata occurs through sexual contact, direct contact with HPV-contaminated objects, and from an infected mother to a child during childbirth.…”

“…Risk factors include a history of multiple sexual partners, homosexuality, inconsistent condom use, chronic genital infections, pregnancy, immunosuppression, and smoking. [7,8] In this case, risk factors include multiple sexual partners, inconsistent condom use, and immunosuppressive condition (diabetes mellitus). The incubation period of CA varies from 2 weeks to 9 months.…”

The Effectiveness of Chemical Cautery and Electrosurgery on Anogenital Wart: Systematic Review

“…This may lead to ineffective T cell activation leading to a lack of immunological ignorance and/or tolerance of virus-infected cells. 41 Another study reported that patients with genitourinary infections are prone to AGW recurrence due to repeated stimulation of the skin and mucosa by various pathogens resulting in an increase of HPV colonization. The number of skin lesions are an independent influencing factor for AGW recurrence which causes declinine in the immune system to inhibit and eradicate HPV by T lymphocyte cells.…”

The effectiveness of different immunotherapies in the treatment of condyloma acuminatum: a network meta-analysis of randomized clinical trials

“…There are also cases of auto-inoculation and vertical transmission. 90% of CA is caused by 2 low-risk subtypes, 6 and 11 ( 2 ), while some are also associated with other subtypes, such as 16, 18, 31, 33, and 35. Due to the moist environment of the genital area and excessive folds in the cavity, viruses have an easy chance to hide with a low spontaneous clearance by the body; warts are widely spread, which have a high recurrence rate.…”