Correlation Between Quantitative Measurements of Tear Film Lipid Layer Thickness and Meibomian Gland Loss in Patients With Obstructive Meibomian Gland Dysfunction and Normal Controls

Eom, Youngsub; Lee, Jong Suk; Kang, Su Yeon; Kim, Hyo Myung; Song, Jong Suk

doi:10.1016/j.ajo.2013.01.008

Cited by 183 publications

(154 citation statements)

References 30 publications

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“…There were significant differences in NITBUTs, OSDI and MGL between the MGD group and the control group. These findings were similar to those of previous studies (20,21). In the present study, the NITBUTs in the MGD group were shorter than those in the control group, indicating that MGD affected the stability of the tear film.…”

Section: Discussionsupporting

confidence: 82%

A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction

Zhang

Huang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present study. Testing included administration of the Ocular Surface Disease Index (OSDI), followed by Keratogragh 5M (Oculus, Wetzlar, Germany), measurements of the noninvasive tear film break-up times (NITBUTs), the first tear film break-up point and the morphology of meibomian gland. Meibomian gland loss (MGL) on the upper lid was evaluated using noncontact meibography. The first NITBUT (NITBUTf) was significantly shorter than the average NITBUT (NITBUTav; Mann-Whitney U-test, P<0.01). There was a weak negative Spearman correlation between NITBUTf and OSDI (rs=-0.251, P=0.046) as well as between NITBUTav and OSDI (rs=-0.250, P=0.046). Furthermore, MGL showed a statistically significant Spearman correlation with OSDI (rs= 0.562; P<0.01). In the MGD group, NITBUTf was significantly shorter (P<0.01), and MGL and OSDI score were significantly greater (P<0.01 and <0.01, respectively) than in the control group. In the MGD group, the first tear film break-up point was most frequently located in the inferonasal quadrant, while it was most frequently located in the supertemporal quadrant in the control group, and there was a significant difference with this regard (χ 2 =3.937, P=0.047). In the MGD group, there were significantly more breakups in the lower quadrant than in the upper quadrant (P=0.011), whereas no differences in the number of breakups in each quadrant were observed in the control group (P= 0.429). Furthermore, there was no significant difference in the breakups in the lower quadrants of the two groups (χ 2 =0.525, P=0.469). In the MGD group, there were significantly more breakups in the lower quadrant than in the upper quadrant (P=0.011), whereas no differences in the number of breakups in each quadrant were observed in the control group (P= 0.429). Furthermore, there was no significant difference in the breakups in the lower quadrants of the two groups (χ 2 =0.525, P=0.469). As the NITBUTs showed only a weak correlation with OSDI, they may not be a strong indicator of the OSDI. However, MGL indicated changes of meibomian gland morphology in the MGD group and the first tear film break-up point was likely located in the inferonasal quadrant in the MGD group.

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Section: Discussionsupporting

confidence: 82%

A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction

Zhang

Huang

et al. 2017

Experimental and Therapeutic Medicine

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“…44 Although current settings for meibomian gland imaging in vivo do not allow evaluation of the volume of meibum inside meibomian glands, they are sufficient to provide an indirect index of meibomian gland function. We have also developed methodology for quantitative evaluation of meibography images 27 and have applied such quantitation in the present study, revealing it to be sufficient for statistical analysis.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Effects of Eyelid Warming Devices on Tear Film Parameters in Normal Subjects and Patients with Meibomian Gland Dysfunction

et al. 2015

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“…In this study, although the patients did show improvement after 4 weeks of the treatment, the improvement in OSDI score was not statistically significant. These results were hypothesized to be possibly due to dysfunctional pain nociceptors, associated with long-lasting dry eye [58][59][60][61][62].…”

Section: Symptom Scoresmentioning

confidence: 99%

Treatment for meibomian gland dysfunction and dry eye symptoms with a single-dose vectored thermal pulsation

Blackie

Carlson²,

Korb

2015

Current Opinion in Ophthalmology

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Correlation Between Quantitative Measurements of Tear Film Lipid Layer Thickness and Meibomian Gland Loss in Patients With Obstructive Meibomian Gland Dysfunction and Normal Controls

Cited by 183 publications

References 30 publications

A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction

A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction

Effects of Eyelid Warming Devices on Tear Film Parameters in Normal Subjects and Patients with Meibomian Gland Dysfunction

Treatment for meibomian gland dysfunction and dry eye symptoms with a single-dose vectored thermal pulsation

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