Correlation between Prolactin Serum with Neutrophil Lymphocyte Ratio (NLR) in Systemic Inflammatory Response Syndrome

Abstract

Background: Systemic inflammatory response syndrome (SIRS) is a state of systemic inflammatory activation by various causes. SIRS have a high mortality rate. Prolactin is known to regulate cellular function of immune system. Neutrophil-lymphocyte ratio (NLR) is simple, cost effective and easy parameter that currently used as inflammation marker.Objective: The aims of this study is to determine the correlation between prolactin serum with NLR in SIRS patients.Methods: A cross sectional study was conducted on 50 clinically SIRS patients. Prolactin serum was measured by enzyme linked immunosorbent assay (ELISA) and NLR was calculated manually from absolute neutrophil and lymphocyte count measured by automatic hematology analyzer. Non-parametric Spearman test was used to analyze the correlation between prolactin with NLR.Results: Median value of serum prolactin level was 11.32 ng/mL (2.76-194.81), whereas the mean value NLR was 16.36 ± 11.58. The correlation between prolactin levels with NLR was r = 0.345, p = 0.014.Conclusion: There is a weak positive significant correlation between prolactin with neutrophil lymphocyte ratio in SIRS

The crucial role of prolactin-lactogenic hormone in Covid-19

“…Indeed, experimental study demonstrated that psychological stress-induced PRL secretion result in the induction of intestinal inflammation via alteration function of dendritic and T cells [29]. Further molecular studies revealed that PRL can activate expression of inducible nitric oxide synthase (iNOS) in the peripheral mononuclear cells via STAT5 signaling pathway and interferon regulatory factor 1 (IRF-1) [30]. Likewise, experimental study illustrated that expression of ePRL in the macrophages and monocytes are activated by adrenergic pathways with subsequent polarization of macrophages toward the inflammatory one (M1) [31].…”

Gambaran Profil Lipid Dan Rasio Neutrofil Limfosit Pada Pasien Sindrom Koroner Akut Di Rsup Sanglah Tahun 2021

“…Studi lain menunjukkan bahwa kadar NLR lebih tinggi terjadi pada pasien dengan kadar kolesterol HDL lebih rendah, menandakan ada peradangan yang lebih besar. 16…”