Correlation Between Pesticide Use in Agriculture and Adverse Birth Outcomes in Brazil: An Ecological Study

Siqueira, Marília Teixeira de; Braga, Cynthia; Cabral-Filho, José Eulálio; Augusto, Lia Giraldo da Silva; Figueirôa, José Natal; Souza, Ariani Impieri de

doi:10.1007/s00128-010-0027-8

Cited by 34 publications

(32 citation statements)

References 10 publications

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“…Por outro lado, não foi observado um padrão similar em relação ao baixo peso ao nascer, o qual tem sido associado com a exposição a agrotóxicos, tanto no Brasil 23 , como em outros países 15,29,30,31 .…”

Section: Resultsunclassified

“…A literatura científica revela a escassez de estudos ecológicos apontando para uma associação positiva entre exposição a agrotóxicos e prematuridade 9 . De Siqueira et al 23 recém-nascido. Assim, um aspecto importante do possível efeito dos agrotóxicos consiste no fato de que um aumento dos nascimentos precoces acarrete um incremento na mortalidade infantil 35 .…”

Section: Resultsunclassified

“…Alguns estudos ecológicos também estudaram a associação entre uso ou consumo de agrotóxicos e risco de eventos adversos na gravidez, mas, em geral, os resultados destes estudos têm sido menos consistentes 22,23 .…”

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Exposição a agrotóxicos e eventos adversos na gravidez no Sul do Brasil, 1996-2000

et al. 2012

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O Brasil é o primeiro mercado mundial consumidor de agrotóxicos. Evidências epidemiológicas apontam associação entre exposição materna a agrotóxicos e eventos adversos na gravidez. Realizou-se um estudo ecológico para investigar possíveis associações entre o consumo per capita de agrotóxicos por microrregiões e eventos adversos em nascidos vivos na Região Sul do Brasil no período 1996-2000. Dados foram obtidos junto ao Instituto Brasileiro de Geografia e Estatística (IBGE) e ao Departamento de Informática do SUS (DATASUS). Microrregiões foram agrupadas segundo quartis de consumo de agrotóxicos e foram calculadas razões de prevalência (RP). O teste qui-quadrado foi usado para calcular o valor de p de tendência lineal. Nas microrregiões de maior consumo de agrotóxicos nascimentos prematuros (< 22 semanas) e de índice de Apgar 1º e 5º minuto insatisfatório (< 8) apresentaram RP significativamente maiores, tanto em meninos como em meninas. Não foi observado um padrão similar em relação a baixo peso ao nascer. Estes achados sugerem a exposição intraútero a agrotóxicos como possível fator de risco para eventos adversos na gravidez, como parto prematuro e maturação inadequada.

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Exposição a agrotóxicos e eventos adversos na gravidez no Sul do Brasil, 1996-2000

et al. 2012

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“…Nevertheless, exposure assessment relied on self-report as well and results should therefore be interpreted with caution. Many studies have reported no increased risk of CAs in offspring residing in areas with pesticide use (de Siqueira et al, 2010; Marshall et al, 1997). Potential association between permethrin/benzyl benzoate lotion during pregnancy for therapeutic reasons (headlice and/or scabies treatment) and CAs was investigated in one study (Kennedy et al, 2005) concluding that no association exists and thus these pesticides are safe.…”

Section: Pesticides and Development Of Congenital Abnormalitiesmentioning

confidence: 99%

Association of pesticide exposure with human congenital abnormalities

Kalliora

Mamoulakis

Vasilopoulos

et al. 2018

Toxicology and Applied Pharmacology

102

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Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, neurodevelopmental toxicants, immunotoxicants, and carcinogens. We reviewed the international literature on this subject for the years between 1990 and 2017. The studies were considered in this review through MEDLINE and WHO resources. Out of the n = 1817 studies identified, n = 94 were reviewed because they fulfilled criteria of validity and addressed associations of interest. Epidemiological studies have provided limited evidence linking pre- and post-natal exposure to pesticides with cancers in childhood, neurological deficits, fetal death, intrauterine growth restriction, preterm birth, and congenital abnormalities (CAs). In this review, the potential association between pesticide exposure and the appearance of some human CAs (including among others musculoskeletal abnormalities; neural tube defects; urogenital and cardiovascular abnormalities) was investigated. A trend towards a positive association between environmental or occupational exposure to some pesticides and some CAs was detected, but this association remains to be substantiated. Main limitations of the review include inadequate exposure assessment and limited sample size. Adequately powered studies with precise exposure assessments such as biomonitoring, are warranted to clarify with certainty the potential association between pesticide exposure and human CAs.

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“…103 Adverse birth outcomes; ecological study: 26 Brazilian states; data from SINASC and SIM; period: 12 mo, 2009.…”

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A Systematic Review of Children's Environmental Health in Brazil

Asmus

Câmara

Landrigan

et al. 2016

Annals of Global Health

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In the region of the Americas, approximately 100,000 children under the age of 5 years die each year due to environmental hazards. Brazil, due to its large size and wide range of environmental challenges, presents numerous hazards to children's health. The aim of this study was to systematically review the scientific literature that describes children's exposures to environmental pollutants in Brazil and their effects on Brazilian children's health. A systematic review of the scientific literature was performed without language restrictions and time of publication (years). The literature search was conducted in the following key resources: PubMed (MEDLINE), Scopus and Web of Science with the MeSH Terms: Environmental exposure AND Brazil (filters: Human, Child [birth to 18 years] and Affiliation Author). The Virtual Health Library was also employed to access the databases Scielo and Lilacs. The search strategy was [DeCS Terms]: Child OR adolescent AND Environmental exposure AND Brazil. Health effects in children associated with exposure to environmental pollutants in Brazil were reported in 74 studies, during the period between 1995 and 2015. The most frequently cited effect was hospital admission for respiratory causes including wheezing, asthma, and pneumonia among children living in areas with high concentrations of air pollutants. A broad spectrum of other health effects possibly linked to pollutants also was found such as prematurity, low birth weight, congenital abnormality (cryptorchidism, hypospadia, micropenis), poor performance in tests of psychomotor and mental development, and behavioral problems. Exposure to pesticides in utero and postnatally was associated with a high risk for leukemia in children <2 years old. These results show that there is a need in Brazil for stricter monitoring of pollutant emissions and for health surveillance programs especially among vulnerable populations such as pregnant women and young children.

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Correlation Between Pesticide Use in Agriculture and Adverse Birth Outcomes in Brazil: An Ecological Study

Cited by 34 publications

References 10 publications

Exposição a agrotóxicos e eventos adversos na gravidez no Sul do Brasil, 1996-2000

Exposição a agrotóxicos e eventos adversos na gravidez no Sul do Brasil, 1996-2000

Association of pesticide exposure with human congenital abnormalities

A Systematic Review of Children's Environmental Health in Brazil

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