Correlation between p53 mutations and HPV in bilharzial bladder cancer

Human papillomavirus detection in Moroccan patients with bladder cancer

“…The high prevalence of HPV infection in the present study demonstrates an association between HPV and UC. These findings were very similar to those obtained from studies conducted in Egypt [19,28] and Italy [32]. In contrast, other studies reported no detection of HPV [7,26,33].…”

“…HPV was observed at a low percentage in South Africa (1.1%) [18] and no evidence of HPV infection was detected by morphological examination and PCR in any case of bladder carcinoma from Tunisian patients [7]. In contrast, a PCR-based study has revealed the detection of HPV DNA sequences in 49% cases of bladder cancer from Egyptian patients [19]. In Morocco, the prevalence of HPV has not yet been clarified, which led to our decision to conduct a study to elucidate this point.…”

“…A PCRbased study by Khaled et al reported that infection with HPV type 16 is the most frequent type (64.6%), whereas the other types are less frequent: HPV type 18 in 18.7%; HPV types 6/11 in 6.2%; and co-infection with HPV types 16 and 18 in 10.4% [19].…”

“…HPV was found to be rare in South Africa (1.1%) [18] and absent in Tunisia [7]. In contrast, a PCR-based study reported the detection of HPV DNA sequences in 49% cases of bladder cancer in Egypt [19].…”

The prognostic value of c‐Kit, K‐ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer

“…Therefore, patients who have the proline tumor genotype and nonmissense sequence variants or missense sequence variants that affecting the L2 or L3 loop domains of the p53 protein have significantly poorer disease-specific survival compared with patients who have wild-type or other sequences. 39 It is interesting to note that this polymorphism in codon 72 has been reported in other solid tumors in the Egyptian population, including bilharzial bladder cancer 40 and hepatocellular carcinoma, 41 suggesting that there are specific environmental or racial contributions in this population. Third, transversion mutations were slightly more common than transitions in our series (50% vs 45.4%, respectively), and there was a high rate of mutations at CpG dinucleotides (20 events).…”