Human papillomavirus detection in Moroccan patients with bladder cancer

Berrada, Noâma; Albouzidi, A.; Ameur, A.; Abbar, M.; Elmzibri, Mohammed; Ameziane-El-Hassani, Rabii; Benbacer, Laïla; Khyatti, Meriem; Qmichou, Zineb; Amzazi, Saaïd; Attaleb, Mohammed

doi:10.3855/jidc.3068

Cited by 21 publications

(20 citation statements)

References 33 publications

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“…High-risk HPVs are the primary causative agents of carcinomas (32). The prevalence of high-risk HPV in BC varies, particularly in Moroccan patients, with the highest prevalence of 52.4% (33). However, clinical trials have reported that HPV is not associated with the risk of BC (34,35).…”

Section: Discussionmentioning

confidence: 99%

Expression and prognostic value of SULT1A2 in bladder cancer

Chao

Shang

2021

Exp Ther Med

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Sulfotransferase Family 1A Member 2 (SULT1A2) is a protein coding gene. Several studies have reported that SULT1A2 may have a chemical carcinogenic effect if expressed as a functional protein. The present study aimed to investigate the expression and potential role of SULT1A2 in bladder cancer (BC). Data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases were used to analyze SULT1A2 expression in BC. In addition, reverse transcription-quantitative PCR and western blot analyses were performed to detect SULT1A2 expression in BC cells and tissues. Immunohistochemistry analysis was performed on 100 formalin-fixed, paraffin-embedded BC tissues and corresponding adjacent normal bladder tissues (ANBTs) to verify SULT1A2 expression and determine the clinical significance of SULT1A2 in BC. Gene set enrichment analysis (GSEA) was performed to determine the potential biological processes and internal molecular mechanisms. The results demonstrated that SULT1A2 was highly expressed in BC tissues compared with ANBTs. Furthermore, high SULT1A2 expression was significantly associated with the staging of BC. Analyses of TCGA datasets and BC tissue microarray indicated that high SULT1A2 expression was significantly associated with a favorable overall survival in patients with BC. In addition, GSEA revealed pathways, diseases and biological processes associated with SULT1A2. Taken together, the results of the present study suggest that SULT1A2 acts as an oncogene in BC, and thus may serve as a biomarker for tumor staging and prognosis in patients with BC.

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Section: Discussionmentioning

confidence: 99%

Expression and prognostic value of SULT1A2 in bladder cancer

Chao

Shang

2021

Exp Ther Med

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“…This finding indicated that HPV16/18 infection probably participated in the occurrence of transitional cell carcinoma of the bladder and had a certain influence on the malignancy and progression of the disease. Berrada et al [12] conducted a test over the high-risk HPV DNA in the tumor tissue of 45 bladder cancer patients from Morocco. The results implied that high-risk HPV infection, especially HPV16 infection, was related to the occurrence and development of bladder cancer.…”

Section: High-risk Hpv Infection and Bladder Cancermentioning

confidence: 99%

The high-risk HPV infection and urinary system tumor

Wen-yan¹

2018

Infection International

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HPV is classified into high-risk and low-risk types depending on its probability of leading to tumorigenesis. Many studies have shown that HPV infection, especially the infection caused by the high-risk type, is always related to prostate cancer, bladder cancer, penile cancer, testicular cancer, and other urinary system tumors. However, previous studies differed in sexual openness and racial genetic susceptibility of the study object, sample size, and experimental methods. Hence, the correlation between high-risk HPV infection and urinary system tumors remains controversial. The early open reading frame of the HPV genome is composed of E1–E7, among which E6 and E7 are the key transfer proteins. The combination of these proteins with oncogene and anti-oncogene may be one of the mechanisms leading to tumorigenesis.

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“…HPV16, and to a lesser extent HPV18, were the most common HPV types in cancer tissue [52] . Geographic variation was striking as evidenced by two studies from North Africa with HPV DNA was detected in 22 (52.4%) of 43 of fresh bladder cancers from Moroccan patients whereas HPV DNA was not detected in any of 125 formalin fixed bladder cancers among Tunisian patients [56,57]. One study found that HPV risk for bladder cancer was greater than for non-smokers [58].…”

Section: Bladder Cancermentioning

confidence: 99%

Human Papilloma Virus (HPV) Infection and Non-Cervical Oncogenic Disease States

Merkhofer

Maslow²

2015

Virol Mycol

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Human papillomavirus (HPV) infection is causative for cervical cancer and has been implicated in cancers at other sites. We review the English language literature in regard to the epidemiology of HPV infection as a risk for non-cervical cancer with a focus on the molecular evidence to support HPV having an etiologic role at each anatomic site. HPV DNA is detected in and/or serology provides evidence that HPV is associated with 35-50% of penile cancers, 80-95% of anal cancers, and ~35% of oropharyngeal cancers. HPV has also been implicated for cancer of the larynx, esophagus, lung, and urinary bladder with varying levels of linkage. Molecular studies at the respective anatomic sites provide evidence of HPV integration, E6 and E7 oncogene expression coupled with tumor suppressor down-regulation consistent with a role in the pathogenesis of tumor formation. HPV-associated cancer may represent a distinct disease entity relative to non HPV-associated cancers based upon natural history and outcome studies. Thus, the disease burden of HPV associated non-cervical cancers may be significant and justifies a comprehensive investigation of the utility of global prophylactic vaccination strategies.

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Human papillomavirus detection in Moroccan patients with bladder cancer

Cited by 21 publications

References 33 publications

Expression and prognostic value of SULT1A2 in bladder cancer

Expression and prognostic value of SULT1A2 in bladder cancer

The high-risk HPV infection and urinary system tumor

Human Papilloma Virus (HPV) Infection and Non-Cervical Oncogenic Disease States

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