Correlation between osteoporosis and cardiovascular disease

Sprini, Delia; Rini, Giovam Battista; Stefano, L. Di; Cianferotti, Luisella; Napoli, Nicola

doi:10.11138/ccmbm/2014.11.2.117

Cited by 46 publications

(68 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The literature reports broadly inform about higher incidence rates of osteoporosis in patients affected by arterial hypertension and type 1 diabetes mellitus [2,3,19] and about increased risk of bone fractures in patients with DM t. 2 [20] (RAC-OST-POL study showed also that diabetes t. 1 increased the risk of fall [21]) -in our study, probably, it would be easier to illustrate the difference in the case of a higher number of patients.…”

Section: Discussionmentioning

confidence: 83%

“…Only scarce reports indicate that osteoprotegerin most effectively illustrates the bone-arterial relationships [5,18] and, while controlling osteoclast activity and functions, it also influences the process of calcification and atherosclerosis (90% of atherosclerotic plaques undergo calcification), being also associated with an increased risk of diabetes mellitus and death from cardiovascular disease [2]. It is also reported that BMPs (bone morphogenetic proteins), ALP (alkaline phosphatase), and OPN (osteopontin) -factors involved in osteogenesis -are correlated with vascular calcification [19]. In the literature there is also suggestion that osteocalcin is important not only for bones but also for glucose and fat metabolism [24].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Correlations between 10-year risk of death from cardiovascular diseases

Kawińska-Hamala

Kawiński

Stanek

et al. 2017

Endokrynologia Polska

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Correlations between 10-year risk of death from cardiovascular diseases

Kawińska-Hamala

Kawiński

Stanek

et al. 2017

Endokrynologia Polska

View full text Add to dashboard Cite

“…A 2DM korai manifesztációja azt jelenti, hogy a serdülőkorban vagy fi atal felnőttkorban induló 2DM szövődményei -mint a vascularis szövődmények és a patológiájában közös kapcsolati pontokat [13] mutató csontállomány eltérése ismég az aktív életkorban fog problémát jelenteni. Fontos lenne tudni, hogy egy korán elkezdett diabetesprevenció jelent-e előnyt a csontok vonatkozásában.…”

Section: Megbeszélésunclassified

A genetikai diabeteskockázat hatása a csontanyagcsere–energia-háztartás kapcsolatokra

Fék¹,

Buday²,

Kovács³

et al. 2015

Orvosi Hetilap

View full text Add to dashboard Cite

1Therapiezentrum Wolkersdorf, Schwabach, Németország 2 DRC Gyógyszervizsgáló Központ Kft., BalatonfüredBevezetés: A 2-es típusú cukorbetegség fokozott csonttörési kockázattal jár, hiányzik a cukoranyagcsere és a csontát-épülés közötti kapcsolat. Nem ismert, hogy ez a romló anyagcserehelyzet miatt alakul ki vagy a diabetes genetikai kockázatának része. Célkitűzés: A szerzők 2-es típusú cukorbetegekben e kapcsolat hiányának hátterét kívánták tisztázni. Módszer: A cukorterhelések és hyperinsulinaemiás-normoglykaemiás klemp alapján 18 egészséges, de a 2-es típusú cukorbetegség genetikai kockázatát hordozó nőt (családban elsőfokú 2-es típusú cukorbeteg rokon) hasonlí-tottak 26 negatív családi anamnézisű egészséges nőhöz. Eredmények: Az egésztest-cukorfelhasználás és a csont metabolikus egységei közötti kapcsolat a diabetes genetikai kockázatát hordozó nőkben hiányzott, amint a manifeszt cukorbetegekben is. A kockázati csoportban csökkent a nagy molekulájú, kis denzitású és nőtt a kis molekulájú, magas denzitású LDL-molekulák mennyisége, ami gyulladásos citokinszaporulattal és a csontbontás túlsúlyával társult. Következtetések: Az eredmények alapján a kapcsolat hiánya nem a romló inzulinérzékenység és romló anyagcserehelyzet következménye, hanem a genetikai kockázat egyik jellegzetessége. A glükózintolerancia és az inzulinrezisztencia kialakulását megelőző lipideltérés oka nem ismert. Orv. Hetil., 2015, 156(25), 1007-1013.Kulcsszavak: 2-es típusú diabetes mellitus, genetikai kockázat, csontanyagcsere, lipidek The effect of genetic risk of diabetes on bone and energy homeostasis connectionsIntroduction: Type 2 diabetes is associated with increased risk of bone fractures, and the connection between bone remodeling and carbohydrate homeostasis is decoupled. It is not known whether these phenomena are the consequence of the deteriorating glucose metabolism, and the increasing insulin resistance or they belong to the genetic risk of type 2 diabetes. Aim: The aim of the authors was to clarify the impact of genetic risk on bone and carbohydrate homeostasis connections. Method: Hyperinsulinemic-normoglycemic clamps, and oral and iv. glucose loads were done to select 18 metabolically healthy females with fi rst degree type 2 diabetic relatives -and 26 without diabetic relatives. Results: The connections between total body glucose utilization and the activity of the bone metabolic unit were missing in healthy females with the genetic risk of type 2 diabetes, like in those with manifest diabetes. In this risk group the level of low-density-large molecular sized LDL lipids were decreased, while the high-density LDL group with low molecular size was increased. The latter change was in signifi cant connection with increased interleukin-6 levels and increased bone resorption within the bone metabolic unit. Conclusions: These data suggest that the missing connection between glucose and bone metabolism is not the consequence of the developing insulin resistance and deteriorating glucose metabolism, but rather it belongs to the inherit...

show abstract

“…However, the majority of the studies have shown that individuals with CVD have a higher risk of experiencing bone loss and thus greater predisposition to risk of fracture [4]. On the other hand there is growing evidence that individuals with low bone mass have higher mortality for cardiovascular events compared to patients with cardiovascular disease with normal bone mass [2]. The nature of the putative link between osteoporosis and CVD remains unclear.…”

mentioning

confidence: 99%

“…Introduction: Cardiovascular diseases (CVD) and osteoporosis are important causes of morbidity and mortality in the elderly [1,2]. Osteoporosis is a serious public health concern with an estimated worldwide incidence of over 200 million.…”

mentioning

confidence: 99%

Investigation of calcium metabolism in patients with coronary heart disease complicated by chronic heart failure, stage ii-a

Khrystyna

Liudmyla

Halyna

et al. 2018

Bangladesh J Med Sci

View full text Add to dashboard Cite

Abstract:Objective: This study aims to to investigate calcium metabolism indices and bone mineralization in patients with coronary heart disease complicated by stage II-A chronic heart failure. Materials and Methods: The study involved 33 men with coronary heart disease (CHD) complicated by Stage II-A chronic heart failure (according to the classification by N.D. Strazhesko, V.H. Vasilenko and G.F. Lung (1935). Bone mineral density was measured using dual energy x-ray densitometry of lumbar region of spine. The level of 25-hydroxyvitamin D (25(ОН)D) has been detected by ELISA method using commercial Vitamin D3 screening kit (Switzerland). The level of ionized calcium was measuring by ion selective method using analyser of electrolytes AEK-01 (QuertiMed, Ukraine). Results and Discussion: Structural and functional changes of bone tissue of the lumbar spine have been found in 49,2 percent patients with coronary heart disease complicated by Stage II-A chronic heart failure, in particular, I stage of osteopenia -in 44,6 %, II stage of osteopenia -in 27,7 %, III stage of osteopenia -in 10,8 % and osteoporosis -in 16,9 %. It was established the same type of downward trend for BMD decreasing in L 1 of patients with different stages of osteopenia, but in case of osteoporosis mineralization decreased equally in all vertebrae. The analysis of calcium metabolism indices indicate that concentration of ionized calcium significantly decreased in patients with CHD complicated by Stage II-A chronic heart failure vs control (1.26±0.02 mmol/l) by 11.1 % (I stage of osteopenia), 18.3 % (II stage of osteopenia) and 31.7 % (III stage of osteopenia). Similar tendency was observed towards concentration of 25(ОН)D. Conclusion: In patients with CHD complicated by Stage II-A chronic heart failure we have established statistically significant decrease in serum level of ionized calcium and 25-hydroxyvitamin D concentration. However, we didn't find the relationship between serum calcium, 25-hydroxyvitamin D concentration and bone mineral density. Structural and functional changes of bone tissue of the lumbar spine have been found in 49,2 percent patients with coronary heart disease complicated by Stage II-A chronic heart failure. It was established the same type of downward trend for BMD decreasing in L 1 of patients with different stages of osteopenia, but in case of osteoporosis mineralization decreased equally in all vertebrae.

show abstract

Correlation between osteoporosis and cardiovascular disease

Cited by 46 publications

References 28 publications

Correlations between 10-year risk of death from cardiovascular diseases

Correlations between 10-year risk of death from cardiovascular diseases

A genetikai diabeteskockázat hatása a csontanyagcsere–energia-háztartás kapcsolatokra

Investigation of calcium metabolism in patients with coronary heart disease complicated by chronic heart failure, stage ii-a

Contact Info

Product

Resources

About