Correlation Between Mean Amplitude of Glycemic Excursion and Bone Turnover Markers in Patients with Type 2 Diabetes: A Cross-Sectional Study

Abstract

Objective The present study explores the relationship between glycemic excursion and bone turnover markers. Methods A total of 250 patients with type 2 diabetes mellitus (T2DM) (142 female and 108 male patients) were enrolled in this study. All participants underwent 72 hours of continuous glycemic monitoring to evaluate the mean amplitude of glycemic excursions (MAGE) of each person. Bone turnover markers and other biochemical data were measured for each patient. Linear regression was performed to explore the relationship between bone turnover markers and glycemic excursion. A value of P < 0.05 was considered statistically significant. Results MAGE was negatively correlated to N-terminal propeptide of type 1 collagen (P1NP) female: [odds ratios (95% confidence interval) (OR (95% CI)), −2.516 (−5.389, 0.356)]; male: [−2.895, (−6.521, −0.731)] and C-terminal telopeptide fragments of type-I collagen (β-CTX) female [−0.025, (−0.036, 0.005)]; male [−0.043, (−0.082, 0.003)]. MAGE was still negatively correlated with β-CTX female [−0.036, (−0.198, −0.030)]; male [−0.048, (−0.089, −0.007)] after adjusting for clinical data and biochemical indices. Conclusion An independent negative relationship between glycemic excursion and bone turnover markers in patients with T2DM was identified in this study.

Association of blood glucose change with postoperative delirium after coronary artery bypass grafting in patients with diabetes mellitus: a study of the MIMIC-IV database

“…MAG was calculated according to the following formula: MAG = ∑ (Δglucose)/∑ Δtime, and is expressed as mmol/L/h and mg/dL/h where appropriate ( 16 ). MAGE as the most typical GV index was defined as the average of the absolute values of all adjacent peak–valley differences greater than one standard deviation ( 17 ). MAG was divided into ≤0.77 mmol/L/h and >0.77 mmol/L/h, and MAGE was divided into ≤2.58 mmol/L and >2.58 mmol/L according to their median value, respectively.…”

Recent Advances in Glycemic Management for Hospitalized Diabetic Patients

“…The effects and influencing factors of glycemic management in hospitalized diabetic patients are complex, including the severity of the disease, patient age, disease duration, comorbidities, and treatment measures. Many studies have shown that the severity of the disease is one of the key factors affecting the effectiveness of glycemic management in hospitalized diabetic patients [8,9] . Severe diabetic patients often need more active and effective management measures to control blood glucose.…”

DataSheet_1.xlsx

“…MAG was calculated according to the following formula: MAG = ∑ (Dglucose)/∑ Dtime, and is expressed as mmol/L/h and mg/dL/h where appropriate (16). MAGE as the most typical GV index was defined as the average of the absolute values of all adjacent peak-valley differences greater than one standard deviation (17). MAG was divided into ≤0.77 mmol/L/h and >0.77 mmol/L/h, and MAGE was divided into ≤2.58 mmol/L and >2.58 mmol/L according to their median value, respectively.…”