Correlation between markers of DNA and lipid oxidative damage in maternal and fetoplacental compartment in the mid-trimester of pregnancy

Rejc, Barbara; Karas-Kuzelicki, Natasa; Osredkar, Joško; Geršak, Ksenija

doi:10.1515/jpm-2015-0399

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…These results were updated by Perlugi et al, where decreased levels of glutathione (GSH) were observed and significantly increased levels of several markers of oxidative stress were found in T21 amniotic fluid. The sources of oxidative stress in pregnancy can be various, from the placenta to maternal and fetal tissues, and the induction of oxidative stress reactions could also come from external factors [55].…”

Section: Main Findingsmentioning

confidence: 99%

“…This would also indicate that the relationship between maternal and fetal oxidative stress is complex beyond a simple diffusion. The source of oxidative stress in pregnancy manifests in the placenta, in particular, but also originates from maternal and/or fetal cells and external factors [55]. It can be hypothesized that the correlation is described by some monotonic, but not linear function.…”

Section: Main Findingsmentioning

confidence: 99%

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Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?

Buczyńska

Sidorkiewicz

Ławicki

et al. 2021

JCM

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Despite significant progress in trisomy 21 (T21) diagnostic tools, amniocentesis is still used for the confirmation of an abnormal fetal karyotype. Invasive tests carry the potential risk of miscarriage; thus, screening biomarkers are commonly used before undergoing invasive procedures. In our study, we investigated the possible application of oxidative stress markers in the prenatal screening of trisomy 21. The DNA/RNA oxidative stress damage products (OSDPs), advanced glycation end (AGE) products, ischemia-modified albumin (IMA), alfa-1-antitrypsin (A1AT), asprosin, and vitamin D concentrations were measured in both maternal plasma and amniotic fluid in trisomy 21 (T21) and euploid pregnancies. The obtained results indicated increased levels of DNA/RNA OSDPs and asprosin with simultaneous decreased levels of vitamin D and A1AT in the study group. The diagnostic utility of the plasma measurement based on the area under the received operative characteristic (ROC) curve (AUC) calculation of asprosin (AUC = 0.965), IMA (AUC = 0.880), AGE (AUC = 0.846) and DNA/RNA OSDPs (AUC = 0.506) in T21 screening was demonstrated. The obtained results indicate a potential role for the application of oxidative stress markers in the prenatal screening of T21 with the highest screening utility of plasma asprosin.

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Section: Main Findingsmentioning

confidence: 99%

Section: Main Findingsmentioning

confidence: 99%

Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?

Buczyńska

Sidorkiewicz

Ławicki

et al. 2021

JCM

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“…The OS biomarkers can be found not only in blood but also in placenta [25], amniotic fluid [26], cord plasma [27,28], and urine [17]. A modern diagnostic approach is to offer less invasive or even noninvasive tests for a diagnosis of different pathologies, and saliva seems to be a suitable material.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Zygula

Kosiński

Wroczyński

et al. 2020

Oxidative Medicine and Cellular Longevity

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Aim. Pregnancy-induced hypertension (PIH) and intrauterine growth restriction (IUGR) are both multisystemic disorders of pregnancy that cause perinatal morbidity and mortality. Recently, researchers focused on the role of oxidative stress (OS) as a pathophysiological mechanism in the development of these pathologies. The aim of this study was to compare OS in placental-related pathologies (PIH and IUGR) and uncomplicated pregnancies. We also investigated which salivary OS markers reflect systemic oxidative status and which only reflect the state of the oral cavity. Material and Methods. A total of 104 pregnant women (n=104; 27 with PIH, 30 with IUGR, and 47 controls) were evaluated. Malondialdehyde (MDA), total antioxidant capacity (ORAC), aldehyde dehydrogenase (ALDH), and activity of glutathione peroxidase (GPx) and glutathione transferase (GST) in plasma/whole blood and/or saliva were analysed. Dietary nutrient intake was calculated using a Semiquantitative Food Frequency Questionnaire (SFFQ). Oral health was assessed to eliminate patients with bleeding, severe periodontitis, and other dental pathologies. Results. In the IUGR group, increased concentration of ORAC was observed both in saliva and plasma. Also, lower plasma levels of MDA in IUGR compared to the control group was detected. No sign of oxidative stress was confirmed in the PIH group. The examined groups did not differ regarding diet and markers of inflammation. ORAC in saliva was correlated with its level in plasma. No such correlations for MDA were observed. In the IUGR group, there were no differences in OS markers in plasma, but there was a lower ALDH level in the blood compared to the control group. It confirms OS occurrence in IUGR. In IUGR, a higher activity of salivary ALDH was probably due to worse oral health. Conclusion. Oxidative stress differs between IUGR and PIH groups: the presence of oxidative stress was confirmed only in the IUGR group. Salivary ORAC can be used to estimate ORAC in plasma. The activity of salivary ALDH reflects the state of the oral cavity.

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Oxidative stress biomarkers in pregnancy: a systematic review

Ibrahim,

Khoo,

Ismail

et al. 2024

Reprod Biol Endocrinol

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Background This systematic review explores the level of oxidative stress (OS) markers during pregnancy and their correlation with complications. Unlike previous studies, it refrains from directly investigating the role of OS but instead synthesises data on the levels of these markers and their implications for various pregnancy-related complications such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages. Method Study Design Utilizing a systematic review approach, we conducted a comprehensive search across databases, including MEDLINE, CINAHL (EBSCOhost), ScienceDirect, Web of Science, and SCOPUS. Our search encompassed all publication years in English. Results After evaluating 54,173 records, 45 studies with a low risk of bias were selected for inclusion. This systematic review has underscored the importance of these markers in both physiological and pathological pregnancy states such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages. Conclusion This systematic review provides valuable insights into the role of OS in pregnancy and their connection to complications. These selected studies delved deeply into OS markers during pregnancy and their implications for associated complications. The comprehensive findings highlighted the significance of OS markers in both normal and pathological pregnancy conditions, paving the way for further research in this field.

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Correlation between markers of DNA and lipid oxidative damage in maternal and fetoplacental compartment in the mid-trimester of pregnancy

Cited by 4 publications

References 35 publications

Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?

Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Oxidative stress biomarkers in pregnancy: a systematic review

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