Correlation between integrated evoked EMG and respiratory function following atracurium administration in unanaesthetized humans

Abstract

in six healthy volunteers, integrated evoked electromyography (IEEMG) measured in response to ulnar nerve stimulation was correlated with respiratory function -tidal volume (VT), forced vital capacity ( FVC ), forced expiratory volume in one second (FEVt), maximum negative inspiratory pressure (NIP) Neuromuscular blocking agents are routinely utilized in general anaesthesia to facilitate tracheal intubation and provide adequate relaxation for surgical procedures. Because neuromuscular weakness may lead to hypoventilation and/or upper airway obstruction, not infrequent complications observed in the recovery room, it is important that any residual neuromuscular blockade following a surgical procedure be detected and adequately reversed. J.2 Electrical stimulation of a peripheral nerve with subsequent observation of the mechanical or electromyographic response of its innervated muscle helps to determine the degree of neuromuscular blockade during administration of muscle relaxants. 3-6 Furthermore, correlations between train-of-four and tetanic stimulation and variables of respiratory function have been established. 7-9 However, an inexpensive and reliable, quantitative monitor of mechanical twitch response is as yet CAN J ANAESTH 1990/ 37: 3/pp. 307-12

Time Course of Action and Endotracheal Intubating Conditions of Org 9487, a New Short-Acting Steroidal Muscle Relaxant; A Comparison with Succinylcholine

“…Also, the time until the TOF reached 20% was 6.6 (1.2) min, which provides a relative margin of safety after early reversal of Org 9487, because respiratory function, in particular, diaphragmatic breathing, is reasonably restored at this degree of TOF recovery (21). In case of failed endotracheal intubation, a short duration of the neuromuscular block is required, either by a short intrinsic duration or by early reversibility.…”

Comparison of integrated evoked EMG between the hypothenar and facial muscle groups following atracurium and vecuronium administration

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In 17 healthy patients undergoing 02" N20' isoflurane anaesthesia, following atracurium or vecuronium administration, we compared simultaneous integrated evoked electromyograms (IEEMGs) (33,4 • 5 vs 46,5 • 8 min, P < 0,005)et avec le vEcuronium (46,(5)(6)(7)(8)(9)(10)(11)(12)3 • 20 min, P < 0,005). Quand le T4/TI de I'ORB atteignaitO, 7 • O, 1, celui de rADD n'Etait que de 0,15 (P < 0,05)

Nous avons compare les traces dlectromyographiques int~SgrEs de l'orbiculaire des paupiOres (ORB) et de I'adducteur du petit doigt (ADD) dvoquEs simultanEment par stimulation en train-de-quatre des nerfs facial et cubital; cela, pendant I'anesthEsie avec 02, NzO et isoflurane de 17 sujets sains aprEs injection d'atracurium ou de vEcuronium.

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