KEY POINTS• We recommend optimization of nonopioid pharmacotherapy and nonpharmacologic therapy, rather than a trial of opioids, for patients with chronic noncancer pain.

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for each recommendation provides greater detail. Accordingly, the summary statements for the sixth and seventh recommendation advise: "A clear doseresponse relationship was demonstrated for the outcomes of fatal and nonfatal overdose." The key information section provides more detailed statements for each outcome, with the accompanying estimates of association. We have removed the qualifier "clear" from the summary statement (in the MAGICapp version of the guideline) to address any perceived inconsistency.

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