Correlation between Inertial Impaction and Laser Diffraction Sizing Data for Aerosolized Carrier-based Dry Powder Formulations

Zeng, Xian-Ming; MacRitchie, Helen B.; Marriott, Christopher; Martin, Gary P.

doi:10.1007/s11095-006-9055-9

Cited by 19 publications

(15 citation statements)

References 17 publications

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“…The optimal size of the particles for deposition in the lungs was found to be in the 1-5 µm range. 26,27 For porous particles, which have a low density, their aerodynamic diameter can be smaller than their corresponding geometric diameter, 28 therefore they can be used to improve drug deposition in peripheral regions.…”

Section: Introductionmentioning

confidence: 99%

Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler

Salem¹,

Abdelrahim²,

Eid³

et al. 2011

IJN

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Background: Nanosized dry powder inhalers provide higher stability for poorly water-soluble drugs as compared with liquid formulations. However, the respirable particles must have a diameter of 1–5 μm in order to deposit in the lungs. Controlled agglomeration of the nanoparticles increases their geometric particle size so they can deposit easily in the lungs. In the lungs, they fall apart to reform nanoparticles, thus enhancing the dissolution rate of the drugs. Theophylline is a bronchodilator with poor solubility in water. Methods: Nanosized theophylline colloids were formed using an amphiphilic surfactant and destabilized using dilute sodium chloride solutions to form the agglomerates. Results: The theophylline nanoparticles thus obtained had an average particle size of 290 nm and a zeta potential of −39.5 mV, whereas the agglomerates were 2.47 μm in size with a zeta potential of −28.9 mV. The release profile was found to follow first-order kinetics (r 2 > 0.96). The aerodynamic characteristics of the agglomerated nanoparticles were determined using a cascade impactor. The behavior of the agglomerate was significantly better than unprocessed raw theophylline powder. In addition, the nanoparticles and agglomerates resulted in a significant improvement in the dissolution of theophylline. Conclusion: The results obtained lend support to the hypothesis that controlled agglomeration strategies provide an efficient approach for the delivery of poorly water-soluble drugs into the lungs.

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Section: Introductionmentioning

confidence: 99%

Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler

Salem¹,

Abdelrahim²,

Eid³

et al. 2011

IJN

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show abstract

“…64 Also, SLNs of glucocorticoids, beclomethasone, dipropionate and alendronate sodium (bone resorption inhibitor) are examples of drugs, which have been developed for administration through this method. 5,[65][66][67] The published data show that SLNs could offer an extensive advantage for the local treatment for severe airway diseases as well as for the systemic drug delivery. Table 1 shows the application of SLNs in delivery of various drugs.…”

Section: 52mentioning

confidence: 99%

Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Dolatabadi¹,

Valizadeh²,

Hamishehkar³

2015

Adv Pharm Bull

140

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“…The general applicability of the technique across the entire platform of delivery systems is apparent (46,(50)(51)(52), including the capability to subtract one particle size distribution (lactose) from a binary mixture containing drug particles to achieve a drug only particle size distribution, in the context of DPI development (53). In particular, its versatility in being able to be used noninvasively in the open bench configuration (i.e., by blowing the aerosol through the measurement zone) or in the more traditional sampling mode using a so-called inhalation cell is a distinct advantage compared with methods, such as the cascade impactor, that can only sample invasively.…”

Section: Laser Diffractometrymentioning

confidence: 99%

Non-impactor-Based Methods for Sizing of Aerosols Emitted from Orally Inhaled and Nasal Drug Products (OINDPs)

Mitchell

Bauer²,

Lyapustina³

et al. 2011

AAPS PharmSciTech

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Abstract. The purpose of this article is to review non-impactor-based methods for measuring particle size distributions of orally inhaled and nasal pharmaceutical aerosols. The assessment of the size distributions of sprays and aerosols from orally inhaled and nasal drug products by methods not involving multi-stage cascade impaction may offer significant potential advantages in terms of labor savings and reducing the risk for operator-related errors associated with complex-to-undertake impactor-based methods. Indeed, in the case of nasal spray products, cascade impaction is inappropriate and alternative, and preferably non-invasive methods must be sought that minimize size-related bias associated with the measurement process for these relatively large droplets. This review highlights the options that are available to those involved with product quality assessments, providing guidance on relative strengths and weaknesses, as well as highlighting precautions that should be observed to minimize bias. The advent of Raman chemical imaging, which enables an estimate to be made of the proportion of each particle comprising active pharmaceutical ingredient(s) (APIs), necessitates a re-think about the value of classical microscopy image analysis as now being capable of providing API-relevant information from collected aerosols and sprays.

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Correlation between Inertial Impaction and Laser Diffraction Sizing Data for Aerosolized Carrier-based Dry Powder Formulations

Abstract: Particle size measured by laser diffraction under the employed conditions reflected the aerodynamic properties of the drug. Laser diffraction can be used as on-, in- and/or at-line measurements and controls for dry powder aerosol formulations.

Cited by 19 publications

References 17 publications

Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler

Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler

Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Non-impactor-Based Methods for Sizing of Aerosols Emitted from Orally Inhaled and Nasal Drug Products (OINDPs)

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