Correlation between Human Papillomavirus (HPV) Type and Histology of Warts

Abstract

Forty warts from different patients and of different clinical type were examined histologically and virologically. Eight lesions were found to be associated with human papillomavirus type 1 (HPV 1), 15 tumors were induced by HPV 2, HPV 3 was detected 4 times, HPV 4 twice, and HPV 6 eleven times. HPV 3, HPV 4, and HPV 6 induced warts revealed a correlation between histology and virus type. They are characterized by the so called "edematous type clear cells". In HPV 3 associated flat warts pycnotic nuclei were mainly localized in the center of large vacuoles. In genital warts sickle shaped nuclei were pushed to the margin of the vacuolized cells. The histology of HPV 1 and HPV 2 induced warts was more heterogenous. With one exception HPV 1-induced lesions represented typical myrmecia warts, varying in the number and shape of inclusion bodies. HPV 2 associated common warts, however, revealed 3 very distinct histologic features: (1) Inclusion wart typical for HPV 1, (2) Classical common wart with marked condensation of keratohyalin granules, (3) Warts with extreme vacuolization of squamous and granular cells leading to a honeycomb-like picture.

Abnormalities of epidermal differentiation associated with expression of the human papillomavirus type 1 early region in transgenic mice

“…Such warts or verrucae are typically very hyperplastic, with the proliferative basal cell layer contorted into elongated papillae, thickening of the suprabasal layers (acanthosis), marked hyperkeratosis and parakeratosis (Gross et al, 1982). HPV-1 is the most productive of the human papillomaviruses, and the virus particles form characteristic inclusion bodies in the cell nuclei in the upper layers of the wart; cytoplasmic granules containing the abundant E l-E4 protein are also present in the upper layers.…”

A Human Papillomavirus–Associated Disease With Disseminated Warts, Depressed Cell-Mediated Immunity, Primary Lymphedema, and Anogenital Dysplasia

“…10 A biopsy specimen taken from a pityriasis versicolor-like area revealed similar but less pronounced changes. No signs of dysplasia were present.…”

Role of the Epstein-Barr Virus ZEBRA Protein and HPV in the Carcinogenesis of Nasopharyngeal Carcinoma

“…Initial investigations into a causal role for HPV in the aetiology of head and neck lesions relied upon electron microscopy (EM) or immunohistochemical staining. Human papillomavirus virions could be identified by EM from specimens of papillomas (Frithiof & Wersall 1967), fibromas (Gross et al 1982), verruca, condyloma acuminatav (Shaffer, Reimann & Gysland 1980;Syrjanen, K. J. & Surjanen 1981), focal epithelial hyperplasia, and oral nodular leukoplakias (Jenson et al 1982).…”