Correlation between human gut microbiome and diseases

Madhogaria, Barkha; Bhowmik, Priyanka; Kundu, Atreyee

doi:10.1016/j.imj.2022.08.004

Cited by 30 publications

(24 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Lactobacillus genus was also in lower quantity in type 2 diabetes patients, and Bif idobacterium was in higher quantity compared with control groups. 108,186 Risks for the development of type 2 diabetes have been correlated to the composition of gut microbiota, as well. The alterations in the gut microbiota of individuals with type 2 diabetes have been small compared with the control group, yet a consistent decline in the metabolically beneficial butyrate-producing bacteria was reported.…”

Section: Research�insights From the Cas Content Collectionmentioning

confidence: 99%

“…The human microbiome has been recognized as an essential factor for human health. − Specifically, gut microbes contribute directly and/or indirectly to important physiological activities, including immunomodulation and the regulation of various neurotransmitters, hormones, and metabolites. Dysbiosis is a state characterized by distinct alterations in the microbiome that result in an imbalance in the microbiota, modifications in their functional composition and metabolic performance, or a change in their allocation.…”

Section: Gut-microbiota-participant Bacteriamentioning

confidence: 99%

“…Clostridium difficile infections can also trigger obesity. Generally, obesity is affected by the inflammatory status induced by gut bacteria or their metabolites, which regulate the GBA. , …”

Section: Gut-microbiota-participant Bacteriamentioning

confidence: 99%

“…Generally, obesity is affected by the inflammatory status induced by gut bacteria or their metabolites, which regulate the GBA. 108,185 Diabetes is another metabolic disease that is strongly associated with the gut microbiome. Studies have reported an increased quantity of Villanella, Clostridium, and Bacteroides and a decreased quantity of Lactobacillus, Eubacterium rectale, Blautia coccoides, and Bif idobacterium in children with type 1 diabetes.…”

Section: Research�insights From the Cas Content Collectionmentioning

confidence: 99%

See 3 more Smart Citations

Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders

Sasso,

Ammar,

Tenchov

et al. 2023

ACS Chem. Neurosci.

View full text Add to dashboard Cite

Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that the gut and brain are in constant bidirectional communication, of which gut microbiota and its metabolic production are a major component, and form the so-called gut microbiome–brain axis. Disturbances of microbiota homeostasis caused by imbalance in their functional composition and metabolic activities, known as dysbiosis, cause dysregulation of these pathways and trigger changes in the blood–brain barrier permeability, thereby causing pathological malfunctions, including neurological and functional gastrointestinal disorders. In turn, the brain can affect the structure and function of gut microbiota through the autonomic nervous system by regulating gut motility, intestinal transit and secretion, and gut permeability. Here, we examine data from the CAS Content Collection, the largest collection of published scientific information, and analyze the publication landscape of recent research. We review the advances in knowledge related to the human gut microbiome, its complexity and functionality, its communication with the central nervous system, and the effect of the gut microbiome–brain axis on mental and gut health. We discuss correlations between gut microbiota composition and various diseases, specifically gastrointestinal and mental disorders. We also explore gut microbiota metabolites with regard to their impact on the brain and gut function and associated diseases. Finally, we assess clinical applications of gut-microbiota-related substances and metabolites with their development pipelines. We hope this review can serve as a useful resource in understanding the current knowledge on this emerging field in an effort to further solving of the remaining challenges and fulfilling its potential.

show abstract

Section: Research�insights From the Cas Content Collectionmentioning

confidence: 99%

Section: Gut-microbiota-participant Bacteriamentioning

confidence: 99%

Section: Gut-microbiota-participant Bacteriamentioning

confidence: 99%

Section: Research�insights From the Cas Content Collectionmentioning

confidence: 99%

See 2 more Smart Citations

Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders

Sasso,

Ammar,

Tenchov

et al. 2023

ACS Chem. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The gut microbiota is physiologically composed of Firmicutes, Bacteroides, Proteobacteria, Actinobacteria, Euryarchaeota, and Verrucomicrobia [ 5 ] ( Figure 1 ).…”

Section: The Gut Microbiota and The Intestinal Barriermentioning

confidence: 99%

Gut Microbiota, LADA, and Type 1 Diabetes Mellitus: An Evolving Relationship

et al. 2023

View full text Add to dashboard Cite

There is much evidence confirming the crucial role played by the gut microbiota in modulating the immune system in the onset of autoimmune diseases. In this article, we focus on the relationship between alterations in the microbiome and the onset of diabetes mellitus type 1 and LADA, in light of the latest evidence. We will then look at both how the role of the gut microbiota appears to be increasingly crucial in the pathogenesis of these disorders and how this aspect may be instrumental in the development of new potential therapeutic strategies that modulate the gut microbiota, such as probiotics, prebiotics, and fecal microbiota transplantation.

show abstract