Correlation between esophageal pH-metry and esophagitis in gastroesophageal reflux disease in children

Lupu, Vasile Valeriu; Burlea, Marin; Nistor, Nicolai; Ştreangă, Violeta; Stârcea, Iuliana Magdalena; Paduraru, Gabriela; Ghica, Dragos Catalin; Mitrofan, Elena Cristina; Moscalu, Mihaela; Ignat, Ancuța

doi:10.1097/md.0000000000012042

Cited by 9 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastroesophageal reflux disease (GERD) might result in the dilatation of intercellular space, an important histologic biomarker for erosive esophagitis in children 24 . Lupu et al 25 demonstrated a parallel relation between the scores of pHmetry and the endoscopic lesion. Thus, EGD is reserved for cases of GERD that are unresponsive to clinical treatment.…”

Section: Discussionmentioning

confidence: 94%

Children and adolescents’ health on focus: Gastrointestinal injuries associated with Helicobacter pylori

et al. 2020

View full text Add to dashboard Cite

Objective: To describe the prevalence of Helicobacter pylori (HP) in children and adolescents, and to assess its association with lesions in the esophagus, stomach, and duodenum according to the patient’s life cycle. Methodsː A cross-sectional analytical study with children and adolescents referred to a gastroenterology service and underwent esophagogastroduodenoscopy at a hospital in Vitória, Espírito Santo, Brazil, from 2001 to 2013. Variables analyzed were the following: sex, age, macro and microscopic alterations and severity of infestation. The Chi-square and Fisher's exact tests and adjusted residue analysis were used (α = 5%). Resultsː the prevalence of infection was 24.4%. Esophagitis (29.4%) and gastritis (34.1%) were associated with HP. The life cycle was associated with esophagitis and duodenitis. Infection was associated with life cycle: infants (0.8%), preschool children (10.5%), school-aged children (16.5%), and adolescents (72.2%). The residues showed a strong association between HP and gastritis, and no association between the school-aged and esophagitis. Adolescents were the major contributors to the association between life cycle and infection, and life cycle and lesion. Conclusionsː Infection with HP was associated with esophagitis and gastritis and was higher among adolescents, who had a marked tendency to develop gastritis and a milder tendency to develop esophagitis. The tendency of developing infection and gastritis was not present in the other life cycles. Public policies focusing on promotion and protecting health, especially in vulnerable population groups, are needed.

show abstract

Section: Discussionmentioning

confidence: 94%

Children and adolescents’ health on focus: Gastrointestinal injuries associated with Helicobacter pylori

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The pH-metry is based on the idea that the progression of the acid gastric content in the esophagus during reflux causes a decrease in intraesophageal pH. The method involves measuring the pH in the lower part of the esophagus for a certain period (in our study 24 h) by using an electrode located 5 cm above the cardia and attached to a portable pH-meter with batteries [10][11][12][13][14].…”

Section: Methodsmentioning

confidence: 99%

“…The electrode is lubricated first, then inserted nasally up to 5 cm above the cardia. Each child or relative is instructed to record any symptoms, time and position of the body (supine position, standing) and at the same time to press the button on the device [11][12][13][14]. The test is positive if the pH decreased below four for more than five seconds [17].…”

Section: Methodsmentioning

confidence: 99%

Gastroesophageal Reflux in Children with Asthma

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background: Nowadays it is considered that a specific causal relationship exists between asthma and gastroesophageal reflux (GER), because of the aspiration of gastric refluate which leads to and maintain spasticity even real crisis of paroxystic expiratory dyspnea. This study explores this relationship and evaluates the results after treatment. Methods: 56 children diagnosed with asthma, hospitalized in a regional center of pediatric gastroenterology in Northeast Romania, underwent 24-hour continuous esophageal pH monitoring in order to establish the presence of GER. The Boix-Ochoa score was used to interpret the results. Proton pump inhibitors were administered to those with GER and the patients were reevaluated after 2 months. Results: 39 patients (69.64%) had GER, with a Boix-Ochoa score above normal (N < 11.99), and 17 patients (30.36%) had normal score. After administering proton pump inhibitors for 2 months, 7 patients still had high Boix-Ochoa score (17.95%). The result of this analysis shows that the presence of asthma increases the chance of GER by 2.86 times. Conclusions: In children with asthma we have to look for GER in order to treat, because it can help the treatment of asthma or even solve some cases resistant to standard treatment.

show abstract

“…Each patient or caregiver was trained to record in a table any symptoms occurred, the time and body position (supine, standing) and, at the same time, using the button provided on the device. [12][13][14] All patients with positive score received treatment with proton pump inhibitors and they were evaluated again after 2 months. Statistical Package for Social Sciences software 20 was used for the statistical data processing.…”

Section: Inclusion Criteriamentioning

confidence: 99%

The relationship between gastroesophageal reflux disease and recurrent wheezing in children

et al. 2021

Self Cite

View full text Add to dashboard Cite

Gastroesophageal reflux disease occurs when gastric contents flow back into the esophagus and produce symptoms. Recurrent wheezing affects the quality of life for the patient and family. The association of gastroesophageal reflux with recurrent wheezing is suggested by different studies. The purpose of this study was to explore this relationship and to evaluate the outcome after appropriate treatment.A retrospective study on 85 children with recurrent wheezing, admitted in a pediatric gastroenterology regional center in Romania was performed. 24-hour continuous esophageal pH monitoring was used to evaluate the presence of gastroesophageal reflux and the results were interpreted using the Boix Ochoa score. All patients with positive score received treatment with proton pump inhibitors and they were evaluated again after 2 months.Gastroesophageal reflux was present in 71 children (83.5%), while 14 (16.5%) had a negative score, with a statistic significance (x 2 = 6.88, P = .0086, 95% confidence interval). After 2 months treatment with proton pump inhibitors, the Boix Ochoa score was still positive in 15 patients (21.13%).Recurrent wheezing is a solid reason for evaluating the presence of gastroesophageal reflux by 24-hour continuous esophageal pH-metry. Adequate treatment of gastroesophageal reflux solves also the recurrent wheezing in the majority of patients.Abbreviations: GER = gastroesophageal reflux, GERD = gastroesophageal reflux disease, PPI = proton pump inhibitors.

show abstract

Correlation between esophageal pH-metry and esophagitis in gastroesophageal reflux disease in children

Cited by 9 publications

References 20 publications

Children and adolescents’ health on focus: Gastrointestinal injuries associated with Helicobacter pylori

Children and adolescents’ health on focus: Gastrointestinal injuries associated with Helicobacter pylori

Gastroesophageal Reflux in Children with Asthma

The relationship between gastroesophageal reflux disease and recurrent wheezing in children

Contact Info

Product

Resources

About