Correlation between dermoscopic and histopathological diagnoses of atypical nevi in a dermatology outpatient clinic of the Medical School of São José do Rio Preto, SP, Brazil

Abstract

BACKGROUNDThe incidence of cutaneous melanoma is increasing worldwide. Since it is an aggressive neoplasm, it is difficult to treat in advanced stages; early diagnosis is important to heal the patient. Melanocytic nevi are benign pigmented skin lesions while atypical nevi are associated with the risk of developing melanoma because they have a different histological pattern than common nevi. Thus, the clinical diagnosis of pigmented lesions is of great importance to differentiate benign, atypical and malignant lesions. Dermoscopy appeared as an auxiliary test in vivo, playing an important role in the diagnosis of pigmented lesions, because it allows the visualization of structures located below the stratum corneum. It shows a new morphological dimension of these lesions to the dermatologist and allows greater diagnostic accuracy. However, histopathology is considered the gold standard for the diagnosis. OBJECTIVESTo establish the sensitivity and specificity of dermoscopy in the diagnosis of pigmented lesions suspected of malignancy (atypical nevi), comparing both the dermatoscopic with the histopathological diagnosis, at the Dermatology Service of the outpatient clinic of Hospital de Base, São José do Rio Preto, SP.METHODSAnalysis of melanocytic nevi by dermoscopy and subsequent biopsy on suspicion of atypia or if the patient so desires, for subsequent histopathological diagnosis.RESULTSSensitivity: 93%. Specificity: 42%. CONCLUSIONSDermoscopy is a highly sensitive method for the diagnosis of atypical melanocytic nevi. Despite the low specificity with many false positive diagnoses, the method is effective for scanning lesions with suspected features of malignancy.

Fecal microbiota transplantation and its repercussions in patients with melanoma refractory to anti-PD-1 therapy: scope review

“…In the ileum, the bacterial population is represented by 10 7 to 10 8 CFU/mL, consisting of facultative anaerobes, Enterobacteria, and obligate anaerobes, such as Veilonella, Enterococcus, Clostridium, Bacteroides , and Lactobacillus . On the other hand, in the large intestine, the population reaches the 10 10 and 10 11 CFU/mL and the most frequently found genera are Bacteroides, Bifidobacterium, Escherichia coli, Bacillus, Clostridium, Eubacterium, Fusobacterium, Peptostreptococcus, and Ruminococcus 56 - 58 .…”

“…The greater the positivity of these signs, the greater the probability of the lesion being a malignant melanoma. However, the definitive diagnosis is made through histopathological examination, which can identify the superficial disseminated, nodular, acral lentiginous, or lentigo maligna patterns 10 , 11 .…”

Онкоепідеміологія Меланоми Шкіри В Чернігівській Області Та Проблеми Її Ранньої Діагностики

“…Існують спеціально розроблені алгоритми з оціночними діагностичними крите- Дерматоскопія -неінвазивний метод дослідження in vivo, який дозволяє візуалізувати будову епідермісу, межу дерми та епідермісу, сосочковий шар дерми та пігментацію, які невидимі неозброєним оком. Впровадження у клінічну практику дерматоскопії підвищило точність неінвазивної діагностики меланоми шкіри на 35 % (Antonio et al, 2013), а атипових меланоцитарних невусів -на 17 % (Carli et al, 2000).…”

Raman Sensing and Its Multimodal Combination with Optoacoustics and OCT for Applications in the Life Sciences

“…According to a recent review be Schleusener et al [152], Raman spectroscopy achieved similar results as trained dermatologists using dermoscopy. It should be kept in mind however that dermoscopy has a good sensitivity but a low specificity, e.g., sensitivity of 93% and specificity of 42% [153]. Therefore, improvement of Raman specificity for skin cancer diagnosis is in the focus of current research.…”