Correlation between cytokine levels of amniotic fluid and histological chorioamnionitis in preterm delivery

Negishi, H.; Yamada, Hideto; Mikuni, M; Kishida, Tatsuro; Okuyama, Kazuhiko; Sagawa, Tadashi; Makinoda, S.; Fujimoto, Seiichiro

doi:10.1515/jpme.1996.24.6.633

Cited by 45 publications

(26 citation statements)

References 10 publications

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“…The localisation of both irIL-4 and IL-4R reported by De Moraes-Pinto et al [8] is consistent with that observed in the present study. Immunoreactive IL-4 has been also detected in amniotic fluid obtained from women at term [20,21]. Furthermore, the concentration of irIL-4 in amniotic fluid was not affected by labour status at term [21].…”

Section: Discussionmentioning

confidence: 88%

Immunolocalisation of Interleukin-4 and Interleukin-4 Receptor in Placenta and Fetal Membranes in Association with Pre-Term Labour and Pre-Eclampsia

Henriques

Rice

Wong

et al. 1998

Gynecol Obstet Invest

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The aim of this study was to characterise the localisation and staining intensity of immunoreactive (ir) interleukin-4 (IL-4) and IL-4 receptor (IL-4R) in human placenta and fetal membranes in association with pre-term and term labour, and pre-eclampsia. The data obtained in this study establish the presence of irIL-4 and IL-4R in human placenta and fetal membranes obtained from women at 25–41 completed weeks of gestation. IL-4 and IL-4R immunohistochemical staining was principally localised in villous and chorionic trophoblast, and to amnion epithelial cells. The intensity of IL-4 and IL-4R immunohistochemical staining was not significantly affected by labour status at term or pre-term (p > 0.05), with the exception of IL-4R in the amnion (p < 0.05). In term amnion, IL-4R was only detectable following labour onset. When data were stratified with respect to the presence or absence of pre-eclampsia, no statistical difference in immunohistochemical localisation or staining intensity for either IL-4 or IL-4R could be identified for any of the tissues studied. Co-localisation of IL-4 and IL-4R within gestational tissues may indicate auto- and/or paracrine mechanisms of action for this cytokine. Tissue-specific, labour-associated induction of IL-4R may contribute to the regulation of biological effects of IL-4 within the uteroplacental unit.

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Section: Discussionmentioning

confidence: 88%

Immunolocalisation of Interleukin-4 and Interleukin-4 Receptor in Placenta and Fetal Membranes in Association with Pre-Term Labour and Pre-Eclampsia

Henriques

Rice

Wong

et al. 1998

Gynecol Obstet Invest

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“…The authors found that regardless of the gestational age at rupture, IL-6 from amniotic fluid was the best predictor of HCA. Several other authors have established the importance of inflammatory markers such as IL-8, IL-10, and TNF-α for the prediction of HCA in PPROM [25][26][27][28]. Nonetheless, very few studies had established the role of maternal serum inflammatory markers for the prediction of PPROM.…”

Section: Discussionmentioning

confidence: 99%

Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes

et al. 2018

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Objective: To assess the added value of maternal serum levels of IL-6 in women with preterm-prelabor rupture of membranes (PPROM) as a non-invasive test for the prediction of histological chorioamnionitis (HCA). Methods: This was a prospective cohort study of pregnant women between 20 + 0 and 36 + 6 weeks of gestation with a confirmed diagnosis of PPROM. Logistic regression models were created for the prediction of HCA and compared by assessing the improvement in their Naegelkerke R² as a measure of goodness of fit. Predictive performance of all models was assessed by receiver operating characteristics curve (ROC) analysis and compared by the DeLong method. Results: From 47 women with PPROM, 31 (66%) developed HCA. Maternal serum IL-6 ≥19.5 pg/dL was the best cut-off point for the prediction of HCA (OR = 15; 95% CI: 3.6–61; p < 0.01). A model comprising maternal characteristics and IL-6 ≥19.5 pg/dL showed an area under the curve of 0.85 (95% CI: 0.74–0.95), significantly improving the previous models of IL-6 ≥19.5 pg/dL (R²: 23.3 vs. 34.1%; p = 0.01) or maternal characteristics (R²: 8.4 vs. 34.1%; p < 0.01). Conclusions: A model comprising maternal serum levels of IL-6 plus maternal characteristics proves to be a good non-invasive predictor of HCA.

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“…IL-2 appears not to be produced during normal pregnancies but only in certain pathological conditions, including infectious processes. Negishi et al (25) published findings correlating elevated levels of IL-2 within amniotic fluid with evidence of histologic chorioamnionitis (25). IL-2 secretion has also been implicated in the pathogenesis seen in deranged vasculature of the placenta associated with preeclampsia (11).…”

Section: Discussionmentioning

confidence: 99%

Placental Cellular Immune Response in Women Infected with Human Parvovirus B19 during Pregnancy

Jordan

Huff

DeLoia

2001

Clin Diagn Lab Immunol

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Human parvovirus B19 can cause congenital infection with variable morbidity and mortality in the fetus and neonate. Although much information exists on the B19-specific antibody response in pregnant women, little information is available describing the cell-mediated immune (CMI) response at the maternal-fetal interface. The focus of this study was to characterize the CMI response within placentas from women who seroconverted to B19 during their pregnancies and compare it to controls. Immunohistochemical techniques were used to identify the various immune cells and the inflammatory cytokine present within placental tissue sections. Group 1 consisted of placentas from 25 women whose pregnancies were complicated by B19 infection; 6 women with good outcome (near-term or term delivery), and 19 with poor outcome (spontaneous abortion, nonimmune hydrops fetalis, or fetal death). Group 2 consisted of placentas from 20 women whose pregnancies were complicated with nonimmune hydrops fetalis of known, noninfectious etiology. Group 3 consisted of placentas from eight women whose pregnancies ended in either term delivery or elective abortion. The results of the study revealed a statistically significant increase in the number of CD3-positive T cells present within placentas from group 1 compared to group 2 or 3 (13.3 versus 2 and 1, respectively) (P < 0.001). In addition, the inflammatory cytokine interleukin 2 was detected in every placenta within group 1 but was absent from all placentas evaluated from groups 2 and 3. Together, these findings demonstrate evidence for an inflammation-mediated cellular immune response within placentas from women whose pregnancies are complicated with B19 infection.The placenta plays an integral barrier role in limiting congenital viral infections (18). However, some viruses, transmitted via the blood, are able to circumvent this barrier. Virus within maternal blood reaches the intervillous space and makes intimate contact with the placental trophoblast layer, which can lead to virus transmission across that protective barrier to the fetal side. Transmission can occur through breaks in the placental barrier, via endocytosis or receptormediated transfer.The P blood group antigen globoside is the main cellular receptor for B19 (3,4). Globoside is present not only on cells of the erythroid lineage but also on the surface of placental syncytiotrophoblast and cytotrophoblast cells (17). The presence of the globoside receptor on trophoblast cells may play a role in transmission of the virus across the placenta.B19 infection of pregnant women can lead to vertical transmission of virus to the fetus with outcomes that include spontaneous abortion, fetal anemia, nonimmune hydrops fetalis, and intrauterine fetal death (6,15,23,26,31,36). Although B19 is capable of causing congenital infection, numerous clinical studies show clearly that the majority of women who become infected with B19 during pregnancy deliver healthy infants (9,20,27,29,37). The risk of fetal demise appears to be greatest when infecti...

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Correlation between cytokine levels of amniotic fluid and histological chorioamnionitis in preterm delivery

Cited by 45 publications

References 10 publications

Immunolocalisation of Interleukin-4 and Interleukin-4 Receptor in Placenta and Fetal Membranes in Association with Pre-Term Labour and Pre-Eclampsia

Immunolocalisation of Interleukin-4 and Interleukin-4 Receptor in Placenta and Fetal Membranes in Association with Pre-Term Labour and Pre-Eclampsia

Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes

Placental Cellular Immune Response in Women Infected with Human Parvovirus B19 during Pregnancy

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