Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study

Baio, Gabriella; Rescinito, Giuseppe; Rosa, Francesca; Pace, Daniele; Boccardo, Simona; Basso, Luca; Salvi, Sandra; Calabrese, Massimo; Truini, Mauro; Neumaier, Carlo Emanuele

doi:10.1007/s11307-015-0823-y

Cited by 12 publications

(12 citation statements)

References 21 publications

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“…The mechanism leading to the "presence or absence" of these receptors in tumour is unclear. In our previous clinical studies, we demonstrated a different CaSR level expression (score 0-4) in human primary breast cancers [38], in keeping with other clinical studies that further correlated the different expression level of CaSRs to the tumour proliferation and, in turn, to high risk of bone metastases [37].…”

Section: Plos Onesupporting

confidence: 90%

Manganese-enhanced MRI (MEMRI) in breast and prostate cancers: Preliminary results exploring the potential role of calcium receptors

et al. 2020

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Procedures To preliminary assess the relationship between Manganese Enhanced Magnetic Resonance Imaging (MEMRI) and the expression of calcium receptors in human prostate and breast cancer animal models. Methods NOD/SCID mice were inoculated with MDA-MB-231 breast cancer cells and prostate PC3 cancer cells to develop orthotopic or pseudometastatic cancer animal models. Mice were studied on a clinical 3T scanner by using a prototype birdcage coil before and after intravenous injection of MnCl 2. Assessment of receptor's status was carried out after the MR images acquisition by immunohistochemistry on excised tumours. Results Manganese contrast enhancement in breast or prostate cancer animal models well correlated with CaSR expression (p<0.01), whereas TRPV6 expression levels appeared not relevant to the Mn uptake. Conclusion Our preliminary results suggest that MEMRI appears an efficient tool to characterize human breast and prostate cancer animal models in the presence of different expression level of calcium receptors.

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Section: Plos Onesupporting

confidence: 90%

Manganese-enhanced MRI (MEMRI) in breast and prostate cancers: Preliminary results exploring the potential role of calcium receptors

et al. 2020

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“…In another study carried out in MCF-7 and MDA-MB-231 breast cancer lines, CaSR activation was hypothesized to stimulate cell proliferation by the increase of the phosphocholine production and the expression of choline kinase through activation of Gα12 and Rho [ 22 ]. In addition, in this instance, other findings supported the same hypothesis [ 31 , 32 ]. Two different experimental studies, the former in MCF-7 and MDA-MB-231, and the latter in ER-positive MCF-7 and ER-negative MDA-MB-435 human breast cancer cells, showed that varying the extracellular concentrations of Ca 2+ between 0.5 and 10 mM no [ 18 ] or decreased [ 33 ] cell proliferation occurred.…”

Section: Alterations Of Signaling Pathways In Some Widespread Biolsupporting

confidence: 83%

Recent Advances in Comprehending the Signaling Pathways Involved in the Progression of Breast Cancer

Nicolini

Diodati

Carpi

2017

IJMS

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This review describes recent advances in the comprehension of signaling pathways involved in breast cancer progression. Calcium sensing receptor (CaSR), caveolae signaling, signaling referred to hypoxia-inducing factors and disturbances in the apoptotic machinery are related to more general biological mechanisms and are considered first. The others refer to signaling pathways of more specific biological mechanisms, namely the heparin/heparin-sulfate interactome, over-expression of miRNA-378a-5p, restriction of luminal and basal epithelial cells, fatty-acid synthesis, molecular pathways related to epithelial to mesenchimal transition (EMT), HER-2/neu gene amplification and protein expression, and the expression of other members of the epithelial growth factor receptor family. This progress in basic research is fundamental to foster the ongoing efforts that use the new genotyping technologies, and aim at defining new prognostic and predictive biomarkers for a better personalized management of breast cancer disease.

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“…Intraoperative MRS at the resection margin correctly diagnosed tissue signal increases in tCho/ N -acetylaspartate and tCho/total creatine ratios and assisted in achieving total tumor resection in conjunction with intraoperative conventional MRI [98]. Novel clinical correlations such as a positive correlation between 1 H MRS-detected tCho and immunohistochemistry-detected calcium-sensing receptor in clinical breast cancers have recently been revealed [99]. …”

Section: Cancer Detection and Monitoring Response To Treatmentmentioning

confidence: 99%

Choline metabolism-based molecular diagnosis of cancer: an update

Glunde

Penet

Jiang

et al. 2015

Expert Review of Molecular Diagnostics

108

120

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Abnormal choline metabolism continues to be identified in multiple cancers. Molecular causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine kinase-α, phosphatidylcholine-specific phospholipase C and -D and glycerophosphocholine phosphodiesterases, as well as several choline transporters. The net outcome of these enzymatic changes is an increase in phosphocholine and total choline (tCho) and, in some cancers, a relative decrease of glycerophosphocholine. The increased tCho signal detected by 1H magnetic resonance spectroscopy is being evaluated as a diagnostic marker in multiple cancers. Increased expression and activity of choline transporters and choline kinase-α have spurred the development of radiolabeled choline analogs as PET imaging tracers. Both tCho 1H magnetic resonance spectroscopy and choline PET are being investigated to detect response to treatment. Enzymes mediating the abnormal choline metabolism are being explored as targets for cancer therapy. This review highlights recent molecular, therapeutic and clinical advances in choline metabolism in cancer.

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Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study

Abstract: The presence or absence of choline peak evaluated by (1)H-MRS, well correlated with the expression of CaSR in patients with breast lesions (p < 0.01), supports the hypothesis that CaSR may play an important role in the production of choline in breast cancer.

Cited by 12 publications

References 21 publications

Manganese-enhanced MRI (MEMRI) in breast and prostate cancers: Preliminary results exploring the potential role of calcium receptors

Manganese-enhanced MRI (MEMRI) in breast and prostate cancers: Preliminary results exploring the potential role of calcium receptors

Recent Advances in Comprehending the Signaling Pathways Involved in the Progression of Breast Cancer

Choline metabolism-based molecular diagnosis of cancer: an update

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