Correlation between Chemical Composition of<i>Curcuma domestica</i>and<i>Curcuma xanthorrhiza</i>and Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation

Jantan, Ibrahim; Saputri, Fadlina Chany; Qaisar, Muhammad; Buang, Fhataheya

doi:10.1155/2012/438356

Cited by 98 publications

(84 citation statements)

References 32 publications

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“…Curcuma xanthorrhiza Roxb., an indigenous herb of Southeast Asia countries, is commonly used to bring about uterus tightening (13), particularly in pregnant women after childbirth or when patients suffer from postpartum uterine swelling (14). Xanthorrhizol, a sesquiterpene compound isolated from Curcuma xanthorrhiza Roxb., has been reported to possess not only anticandidal, antibacterial, antimetastatic, and anti-inflammatory activity (15 -17).…”

mentioning

confidence: 99%

In Vitro and In Vivo Effects of Xanthorrhizol on Human Breast Cancer MCF-7 Cells Treated With Tamoxifen

Noomhorm¹,

Chang²,

Wen³

et al. 2014

J Pharmacol Sci

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IntroductionBreast cancer is the most frequently diagnosed cancer among women internationally and is the second highest cause of cancer-related death. The incidence of breast cancer varies hugely around the world, both in developed and developing countries (1). In Thailand, breast cancer is currently the most common cancer and involves 43% of all cancers diagnosed in women (2).Estrogen receptors, when binding with estrogen, have important physiological roles in cardiovascular protection, the humoral immune response, neuroprotection, and bone remodeling. In breast cancer cells, estrogen and/or progesterone receptor status is highly linked to the patients' prognosis after surgery (3). Although many selective estrogen receptor modulators have been studied (4, 5), at present, hormonal therapy with tamoxifen is considered a gold standard when preventing tumor recurrence in women with hormone-responsive breast cancer. Tamoxifen, a non-steroidal selective estrogen receptor modulator, is commonly used for the hormone therapy of receptors-positive breast cancers in pre- Chang-Gung Memorial Hospital, Taoyuan, 333, Taiwan, ROC Received February 2, 2014; Accepted May 8, 2014 Abstract. This study investigated the herb-drug interaction of xanthorrhizol and tamoxifen in human breast cancer cells. Using MCF-7 cell line as an in vitro model, the herb-drug interaction between xanthorrhizol and tamoxifen was measured by MTT assay, luciferase reporter assay, and cell cycle analysis. The effects of xanthorrhizol on growth/autophagy related signaling were determined by immunostaining, western blotting, and real time RT-PCR. Additionally, the in vivo effect of xanthorrhizol and tamoxifen on athymic nude mice implanted with MCF-7 cells was evaluated. When MCF-7 cells were co-treated with tamoxifen and xanthorrhizol, there were no significant changes in terms of cell number, luciferase activity, percentage S-phase cells and LC3-II expression. However, using the MCF-7 implanted nude mice model, it was possible to detect significantly increased tumor volumes, a larger tumor size, and increased protein expression of P38 and P27(Kip1) in the xanthorrhizol + tamoxifen group compared to the tamoxifen-alone group. It can be concluded that while there is no significant herb-drug interaction between xanthorrhizol and tamoxifen in vitro, there is such an interaction in tumor-bearing mice, which provides important information that affects breast cancer treatment translational research. In Vitro and In Vivo Effects of Xanthorrhizol on Human Breast Cancer MCF-7 Cells Treated With Tamoxifen

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confidence: 99%

In Vitro and In Vivo Effects of Xanthorrhizol on Human Breast Cancer MCF-7 Cells Treated With Tamoxifen

Noomhorm¹,

Chang²,

Wen³

et al. 2014

J Pharmacol Sci

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“…Lipid oxidation protection of Javanese turmeric essential oil related to the antioxidant activity of its chemical compounds. Jantan et al (2012) reported that essential oils of C. xanthorrhiza showed high LDL antioxidant activity due to the high levels of xanthorrhizol.…”

Section: Thiobarbituric Acidmentioning

confidence: 99%

Short Communication: Preservation effect of Javanese turmeric and red ginger essential oils on coated frozen patin fillets

et al. 2016

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Abstract. Utami R, Kawiji, Praseptiangga D, Manuhara GJ, Khasanah LU, Anggraini N, Lestari FM. 2016. Short Communication: Preservation effect of Javanese turmeric and red ginger essential oils on coated frozen patin fillets. Nusantara Bioscience 8: 264-267. Due to antimicrobial and antioxidant properties of essential oil, Javanese turmeric and red ginger potentially used as preservation agents on food. Cassava starch-based edible coating enriched with Javanese turmeric and red ginger essential oils were applied to maintaining of patin fillets quality during frozen storage. Fillets quality were analyzed based on microbiological (total plate count) and chemical properties (total volatile bases; thiobarbituric acid value). Different concentration of Javanese turmeric and red ginger essential oil enrichment were studied (0, 0.1, and 1% (v/v of distilled water)). Javanese turmeric and red ginger essential oils enrichment on coating solution significantly inhibited microbial proliferation, retarded protein deterioration and delayed lipid oxidation in fillet during frozen storage for four months. Increasing essential oil concentration showed on the increase in maintaining fish quality. The results indicated that Javanese turmeric and red ginger essential oil addition on cassava starch-based edible coating could maintain quality and extend the shelf life of frozen fish fillets and can be used as an alternative fish fillets preservation.

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“…Three curcuminoid compounds were reported to have antiinflammatory and antioxidant activities (Ramsewak et al,. 2000;Jantan et al, 2012). Xanthorizol, a compound isolated only from C. xanthorrhiza was also reported to have anti-inflammatory and antioxidant activities.…”

Section: Compounds Isolated From Indonesian Medicinal Plants For Use mentioning

confidence: 99%

“…Xanthorizol, a compound isolated only from C. xanthorrhiza was also reported to have anti-inflammatory and antioxidant activities. Two compounds from Curcuma essential oils, ar-turmerone and zerumbone, have antioxidant activity (Jantan et al, 2012) …”

Section: Compounds Isolated From Indonesian Medicinal Plants For Use mentioning

confidence: 99%

Use of Indonesian Medicinal Plants Products Against Acne

Batubara

Mitsunaga

2013

RAS

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Indonesia contains a diverse range of cultures and plants. For a long time, Jamu, which is a traditional Indonesian medicine, had been used for beauty and human health in Indonesia. In this study, Indonesian medicinal plants used for skin care were examined, and the relevant information was update to incorporate anti-acne therapies. The anti-acne mechanisms included antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus, bacterial lipase inhibition, antioxidant, and anti-inflammatory activities. Most of the Indonesian medicinal plants used in skin care showed anti-acne activity that utilized et least 2 of these mechanisms. The compounds isolated from the Indonesian traditional medicinal plants related to the anti-acne activities are also discussed. In conclusion, more research on Indonesian medicinal plants is needed.

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Correlation between Chemical Composition ofCurcuma domesticaandCurcuma xanthorrhizaand Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation

Cited by 98 publications

References 32 publications

In Vitro and In Vivo Effects of Xanthorrhizol on Human Breast Cancer MCF-7 Cells Treated With Tamoxifen

In Vitro and In Vivo Effects of Xanthorrhizol on Human Breast Cancer MCF-7 Cells Treated With Tamoxifen

Short Communication: Preservation effect of Javanese turmeric and red ginger essential oils on coated frozen patin fillets

Use of Indonesian Medicinal Plants Products Against Acne

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