Correlation between C-reactive protein levels with leading risk factors for cardiovascular disease in men

Mirjanic-Azaric, Bosa; Djeric, M.; Vrhovac, Maja; Maleš-Bilić, Ljiljana

doi:10.2298/mpns0804164m

Cited by 2 publications

(4 citation statements)

References 15 publications

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Section: Discussioncontrasting

confidence: 92%

“…The large positive correlation between Total:HDL cholesterol and medium positive correlation between LDL cholesterol and hsCRP was unexpected, and contrasts with previous research that found minimal or no correlation between these markers 75,76 except in children. 77 The medium negative correlation between hsCRP and HDL was also unexpected, as other studies have found no correlation between these two markers.…”

Section: Lipidscontrasting

confidence: 99%

“…77 The medium negative correlation between hsCRP and HDL was also unexpected, as other studies have found no correlation between these two markers. 76,78 Similarly, the medium positive correlation between PAF and HDL cholesterol seems counter intuitive, given HDL is anti-inflammatory. An interaction between PAF and COVID-19 vaccination/disease status may be one explanation.…”

Section: Lipidsmentioning

confidence: 99%

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Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A₂ activity and traditional cardiovascular risk factors

et al. 2022

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Traditionally cardiovascular disease (CVD) risk has been assessed through blood lipids and inflammatory marker C-reactive protein (hsCRP). Recent clinical interest in novel pro-inflammatory markers platelet-activating factor (PAF) and lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) recognizes that vascular damage can exist in the absence of traditional risk factors. This crosssectional study investigated the potential relationship between circulating PAF, Lp-PLA 2 , hsCRP, and traditional risk factors for CVD. One hundred adults (49 ± 13 years, 31% male) with variable CVD risk were recruited. Fasting inflammatory markers PAF, Lp-PLA 2 and hsCRP and total, high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol, and triglycerides were measured. Blood pressure, body mass index, and waist circumference were measured. Medical and physical activity data were self-reported. Linear and multiple regressions were performed. PAF, Lp-PLA 2 , and hsCRP independently correlated with several CVD risk factors. PAF was correlated significantly with risk factors in an unexpected way; there was a medium positive correlation between PAF and HDL cholesterol (r = 0.394, p < 0.001) and medium negative correlations with Total:HDL cholesterol; (r = À0.436, p < 0.001) systolic blood pressure; (r = À0.307, p = 0.001); BMI (r = À0.381, p < 0.001); and waist circumference (r = À0.404, p < 0.001). There were large positive correlations between Lp-PLA 2 and LDL (r = 0.525, p < 0.001) and non-HDL cholesterol (r = 0.508, p < 0.001). There were large positive correlations between hsCRP and Total:HDL cholesterol (r = 0.524, p < 0.001); BMI

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Section: Discussioncontrasting

confidence: 92%

Section: Lipidscontrasting

confidence: 99%

Section: Lipidsmentioning

confidence: 99%

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Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A₂ activity and traditional cardiovascular risk factors

et al. 2022

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“…The levels of blood plasma C-reactive protein (CRP) were characterized quantitatively by diffused light immunoturbidimetric method (Mirjanic-Azaric et al, 2008). The erythrocyte sedimentation rate (ESR) and the contents of blood plasma hemoglobin (Hb) of individual subjects were determined by the Westergen method (Cakal et al, 2009) and measured by an automated hematology analyzer, respectively.…”

Section: Other Clinical Measuresmentioning

confidence: 99%

Higher Levels of CCL20 Expression on Peripheral Blood Mononuclear Cells of Chinese Patients with Inflammatory Bowel Disease

Zhang

et al. 2010

Immunological Investigations

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This study aimed at characterizing the levels of CCL20 mRNA transcripts in peripheral mononuclear blood cells (PMBC) of 56 Chinese patients with inflammatory bowel disease (IBD), 30 other intestinal diseases and 30 healthy controls by quantitative real time polymerase chain reaction. The levels of CCL20 mRNA transcripts in PBMC of patients with IBD were significantly higher than that of patients with non-IBD intestinal diseases and healthy controls (p < 0.01) and the CCL20 expression in active IBD patients was significantly higher than that in remission patients (p < 0.01). Importantly, the levels of CCL20 expression in PBMC were significantly correlated with the degrees of disease severity, the levels of erythrocyte sedimentation rate and C-reaction protein, but not hemoglobin, in patients with IBD (p < 0.01). Furthermore, the levels of CCL20 expression in active IBD patients after treatment with salazosulphapyridine or prednisone were significantly reduced, as compared with before treatment (p < 0.01). Therefore, analysis of CCL20 expression in PBMC may be used as a surrogate measure for evaluation of IBD activity, disease progression and therapeutic efficacy in Chinese IBD patients.

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Correlation between C-reactive protein levels with leading risk factors for cardiovascular disease in men

Abstract: High sensitive CRP screening is useful in early detection and prevention of cardiovascular diseases

Cited by 2 publications

References 15 publications

Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A₂ activity and traditional cardiovascular risk factors

Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A₂ activity and traditional cardiovascular risk factors

Higher Levels of CCL20 Expression on Peripheral Blood Mononuclear Cells of Chinese Patients with Inflammatory Bowel Disease

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Correlation between C-reactive protein levels with leading risk factors for cardiovascular disease in men

Abstract: High sensitive CRP screening is useful in early detection and prevention of cardiovascular diseases

Cited by 2 publications

References 15 publications

Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A2 activity and traditional cardiovascular risk factors

Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A2 activity and traditional cardiovascular risk factors

Higher Levels of CCL20 Expression on Peripheral Blood Mononuclear Cells of Chinese Patients with Inflammatory Bowel Disease

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Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A₂ activity and traditional cardiovascular risk factors

Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A₂ activity and traditional cardiovascular risk factors