Correlation between body mass index and obstructive sleep apnea severity indexes — A retrospective study

Ciavarella, Domenico; Tepedino, Michele; Chimenti, Claudio; Troiano, Giuseppe; Mazzotta, Manuela; Barbaro, Maria Pia Foschino; Muzio, Lorenzo Lo; Cassano, Michele

doi:10.1016/j.amjoto.2018.03.026

Cited by 33 publications

(28 citation statements)

References 23 publications

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“…BMI is a well-established indicator of obesity and frequently used measure defining the severity of respiratory stress associated with OSAS. 52 Our study has some limitations. The sample included severe OSAS patients (AHI>30/h), both males and females.…”

Section: Discussionmentioning

confidence: 89%

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<p>Obstructive Sleep Apnea Syndrome: A Preliminary Navigated Transcranial Magnetic Stimulation Study</p>

Vidaković

Šoda

Jerković

et al. 2020

NSS

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Purpose: An increase in resting motor threshold (RMT), prolonged cortical silent period duration (CSP), and reduced short-latency afferent inhibition (SAI), confirmed with previous transcranial magnetic stimulation (TMS), suggest decreased cortical excitability in obstructive sleep apnea syndrome (OSAS). The present study included MRI of OSAS patients for navigated TMS assessment of the RMT, as an index of the threshold for corticospinal activation at rest, and SAI as an index of cholinergic neurotransmission. We hypothesize to confirm findings on SAI and RMT with adding precision in the targeting of motor cortex in OSAS. Subjects and Methods: After acquiring head MRIs for 17 severe right-handed OSAS and 12 healthy subjects, the motor cortex was mapped with nTMS to assess the RMT and SAI, with motor evoked potentials (MEPs) recorded from the abductor-pollicis brevis (APB) muscle. The 120%RMT intensity was used for the SAI by a paired-pulse paradigm in which the electrical stimulation to the median nerve is followed by magnetic stimulation of the motor cortex at inter-stimulus intervals (ISIs) of 18-28 ms (ISIs 18-28). The SAI control condition included a recording of MEPs without peripheral stimulation. Latency and amplitude of MEP at RMT at 120%RMT for eleven different at ISIs 18-28 were analyzed. Results: The study showed a significantly lower percentage deviation of MEP amplitude at ISIs (18-28ms) from the control condition between OSAS and healthy subjects (U=44.0, p=0.01). The intensity of stimulation at RMT was significantly higher in OSAS subjects (U=55.0, p=0.04*). Correlation analysis showed that BMI significantly negatively correlated (ρ=−0.47) with MEP amplitude percentage deviation in OSAS patients. Conclusion: The nTMS study results in increased RMT, and reduced cortical afferent inhibition in OSAS patients for SAI at ISIs 18-28 , confirming previous findings of impaired cortical afferent inhibition in OSAS. Future nTMS studies are desirable to elucidate the role of RMT and SAI in diagnostics and treatment of OSAS, and to elucidate the usefulness of nTMS in OSAS research.

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Section: Discussionmentioning

confidence: 89%

“…BMI is a well-established indicator of obesity and frequently used measure defining the severity of respiratory stress associated with OSAS. 52 …”

Section: Discussionmentioning

confidence: 99%

<p>Obstructive Sleep Apnea Syndrome: A Preliminary Navigated Transcranial Magnetic Stimulation Study</p>

Vidaković

Šoda

Jerković

et al. 2020

NSS

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“…Seren et al suggests that snoring intensity as well as adenotonsillar size is related to increasing BMI . Furthermore, increased BMI can contribute to increased overall OSA severity and snoring, a hallmark symptom . Our cohort of pediatric patients had BMIs largely within the appropriate range when corrected for age and comorbidities.…”

Section: Discussionmentioning

confidence: 73%

Evaluating the impact of adenotonsillectomy for pediatric sleep‐disordered breathing on parental sleep

et al. 2019

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Objectives/Hypothesis: To evaluate the impact of adenotonsillectomy for pediatric sleep-disordered breathing (SDB) on parental sleep quality, daytime sleepiness, and child quality of life.Study Design: Prospective cohort study. Methods: Pediatric patients aged 2 to 10 years with SDB and suspected obstructive sleep apnea (OSA) requiring adenotonsillectomy were identified at a single tertiary-care pediatric otolaryngology hospital. Parental daytime sleepiness and quality of sleep were evaluated pre-and postoperatively using the Epworth Sleepiness Scale (ESS) and Pittsburg Sleep Quality Index (PSQI), respectively. Child quality of life, in the context of suspected OSA, was evaluated by the Obstructive Sleep Apnea Quality of Life Survey (OSA-18), pre-and postoperatively. Paired-samples t tests were conducted to analyze data.Results: Forty-seven patients with a mean (standard deviation [SD]) age of 4.9 (2.2) years, participated. Mean (SD) parental age was 35.5 (4.6) years. Statistically significant decreases of 2.1 points were observed between preoperative and postoperative parental mean global ESS (P = .007; 95% confidence interval [CI]: 0.6-3.6) and mean total PSQI (P = .001; 95% CI: 0.9-3.1) scores. A statistically significant improvement (41.6 points) was observed between preoperative and postoperative on mean OSA-18 scores (P < .0001; 95% CI: 35.7-47.6).Conclusions: Adenotonsillectomy performed in the pediatric population for SDB, with suspected OSA, can positively impact parental daytime sleepiness and sleep quality in addition to pediatric quality of life.

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“…Another limitation is the short follow-up, which precludes us from making statements on the long-term success of MAD therapy with the proposed device. Possible future improvements of the present protocol could be evaluation of other patient related parameters such as body mass and neck circumference 26 , and assessment of quality of life, since other parameters in addition to AHI can explain the clinical success of therapy 3 , 27 . Further studies could also take into account skeletal features 28 , 29 and volumetric assessment of the upper airway 30 , 31 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of factors that influence the success rate of OSA treatment with a customised adjustable MAD device - a retrospective study

Burlon

Tepedino

Laurenziello

et al. 2020

Acta Otorhinolaryngol Ital

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SUMMARY The aim of the present study was to evaluate how the features of obstructive sleep apnoea (OSA) and the degree of mandibular advancement influence the outcomes of oral appliance therapy with a fully-customised mandibular advancement device (MAD) in an adult population. A total of 85 adult patients with mild to severe OSA were retrospectively selected. Polysomnography was taken before treatment and after 2 months treatment with overnight MAD. Treatment success was defined as a > 50% reduction in the Apnoea/Hypopnoea Index (AHI) with a residual AHI < 10. Binary logistic regression was used to evaluate the effects of AHI, oxygen desaturation index (ODI), gender and age on the success rate of MAD therapy. MAD therapy was successful in 77.7% of patients, and the ODI was a significant predictor of treatment success. OSA treatment with the MAD was successful in reducing the AHI in adult patients. An ODI value smaller than 33.3 was a significant predictor of treatment success.

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Correlation between body mass index and obstructive sleep apnea severity indexes — A retrospective study

Cited by 33 publications

References 23 publications

<p>Obstructive Sleep Apnea Syndrome: A Preliminary Navigated Transcranial Magnetic Stimulation Study</p>

<p>Obstructive Sleep Apnea Syndrome: A Preliminary Navigated Transcranial Magnetic Stimulation Study</p>

Evaluating the impact of adenotonsillectomy for pediatric sleep‐disordered breathing on parental sleep

Evaluation of factors that influence the success rate of OSA treatment with a customised adjustable MAD device - a retrospective study

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