&lt;p&gt;Obstructive Sleep Apnea Syndrome: A Preliminary Navigated Transcranial Magnetic Stimulation Study&lt;/p&gt;

Vidaković, Maja Rogić; Šoda, Joško; Jerković, Ana; Benzon, Benjamin; Bakrač, Karla; Dužević, Silvia; Vujović, Igor; Mihalj, Mario; Pecotić, Renata; Valić, Maja; Mastelić, Angela; Hagelien, Maximilian Vincent; Schönwald, Marina Zmajević; Đogaš, Zoran

doi:10.2147/nss.s253281

Cited by 4 publications

(2 citation statements)

References 59 publications

(159 reference statements)

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“…SAI was significantly reduced in apneic patients compared to healthy controls, and SAI level was strongly correlated with neuropsychological scores, suggesting that cognitive deficits in OSAS may be, at least in part, related to impaired cholinergic neurotransmission, presumably caused by the intermitted nocturnal hypoxemia ( Nardone et al, 2016a ). A more recent navigated TMS study demonstrated an increased rMT and reduced SAI in OSAS, thus confirming previous findings of impaired cortical afferent inhibition in these patients ( Rogić Vidaković et al, 2020 ).…”

Section: Resultssupporting

confidence: 87%

A comprehensive review of transcranial magnetic stimulation in secondary dementia

Lanza

Fisicaro

Dubbioso

et al. 2022

Front. Aging Neurosci.

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Although primary degenerative diseases are the main cause of dementia, a non-negligible proportion of patients is affected by a secondary and potentially treatable cognitive disorder. Therefore, diagnostic tools able to early identify and monitor them and to predict the response to treatment are needed. Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological technique capable of evaluating in vivo and in “real time” the motor areas, the cortico-spinal tract, and the neurotransmission pathways in several neurological and neuropsychiatric disorders, including cognitive impairment and dementia. While consistent evidence has been accumulated for Alzheimer’s disease, other degenerative cognitive disorders, and vascular dementia, to date a comprehensive review of TMS studies available in other secondary dementias is lacking. These conditions include, among others, normal-pressure hydrocephalus, multiple sclerosis, celiac disease and other immunologically mediated diseases, as well as a number of inflammatory, infective, metabolic, toxic, nutritional, endocrine, sleep-related, and rare genetic disorders. Overall, we observed that, while in degenerative dementia neurophysiological alterations might mirror specific, and possibly primary, neuropathological changes (and hence be used as early biomarkers), this pathogenic link appears to be weaker for most secondary forms of dementia, in which neurotransmitter dysfunction is more likely related to a systemic or diffuse neural damage. In these cases, therefore, an effort toward the understanding of pathological mechanisms of cognitive impairment should be made, also by investigating the relationship between functional alterations of brain circuits and the specific mechanisms of neuronal damage triggered by the causative disease. Neurophysiologically, although no distinctive TMS pattern can be identified that might be used to predict the occurrence or progression of cognitive decline in a specific condition, some TMS-associated measures of cortical function and plasticity (such as the short-latency afferent inhibition, the short-interval intracortical inhibition, and the cortical silent period) might add useful information in most of secondary dementia, especially in combination with suggestive clinical features and other diagnostic tests. The possibility to detect dysfunctional cortical circuits, to monitor the disease course, to probe the response to treatment, and to design novel neuromodulatory interventions in secondary dementia still represents a gap in the literature that needs to be explored.

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Section: Resultssupporting

confidence: 87%

A comprehensive review of transcranial magnetic stimulation in secondary dementia

Lanza

Fisicaro

Dubbioso

et al. 2022

Front. Aging Neurosci.

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show abstract

“…Experimental research and neuroimaging studies show effects of intermittent hypoxia on sleepiness, memory and executive dysfunction. In individuals with OSAS, such changes have been attributed to reduced cell neurogenesis and density of the hippocampus [17,50,29], the frontal cortex and generalized grey matter [35,2,39,11].The abnormal changes of gray matter (GM) and white matter may be the important pathological basis of OSAS leading to neurocognitive dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Learning and Memorizing Ability of OSAS rat with Neuroinflammation

Luo¹,

Li²,

Bao³

et al. 2021

Preprint

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Background Obstructive sleep apnea syndrome (OSAS) is a respiratory disorder during sleep that has become a significant public health problem over time. OSAS patients elicited the frontal cortex neuron injury, leading to cognitive dysfunction, a significant and extraordinary complication of OSAS patients. Learning and memory testing is critical when assessing potential therapeutic strategies and the effectiveness of treatments to manage OSAS. The objective of this article was to explore the relationship between inflammation and cognitive dysfunction in OSAS. Methods Selected male rats were 3-months-old and with a similar weight (mean, 200 ± 10 g) were assigned to the model group (n = 30) and the control group (n = 30). The rats in the OSAS model group were injected with 0.1 ml sodium hyaluronate solution into the upper respiratory tract at the junction between the hard and soft palate. The model and normal rats were compared using tests of Morris Water Maze. The tissue sections were stained by hematoxylin eosin(HE) and immunohistochemically(IHC). Results Tests of training test and spatial probe test proved significant differences between 2、4、6 week’s OSAS rats over all swims, p < 0.05. Histopathology showed cortical laminar oedema with vacuolation ,irregular arrangement, disorganization, rods of the nerve cells were identified, astrocyte activation and reactive gliosis ,abundant astrocyte. And IHC staining showed Iba1-positive cells increased as compared to control group. Conclusion We suggest assessing spatial and related forms of learning and memory in OSAS rat by the new statistical method. Microglial and astrocyte activation is involved in OSAS-induced changes in inflammatory molecules, neurogenesis, and spatial memory.

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Transcranial magnetic stimulation for sleep disorders in Alzheimer's disease: A double-blind, randomized, and sham-controlled pilot study

Zhou

Wang

Liu

et al. 2022

Neuroscience Letters

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<p>Obstructive Sleep Apnea Syndrome: A Preliminary Navigated Transcranial Magnetic Stimulation Study</p>

Cited by 4 publications

References 59 publications

A comprehensive review of transcranial magnetic stimulation in secondary dementia

A comprehensive review of transcranial magnetic stimulation in secondary dementia

Exploration of Learning and Memorizing Ability of OSAS rat with Neuroinflammation

Transcranial magnetic stimulation for sleep disorders in Alzheimer's disease: A double-blind, randomized, and sham-controlled pilot study

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