Correlation between auditory brainstem response and hearing prognosis in idiopathic sudden sensorineural hearing loss patients

Lin, Hung‐Che; Chou, Yu‐Ching; Wang, Chih‐Hung; Hung, Li-Wen; Shih, Cheng‐Ping; Kang, Bor‐Hwang; Yeh, Wen-Ying; Chen, Hsin-Chien

doi:10.1016/j.anl.2017.01.004

Cited by 14 publications

(13 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SNHL is defined as hearing loss resulting from damage to the inner ear or the auditory nerves that aid in the sound transducing mechanism to the brain (Luo et al, 2017 ). SSNHL is a form of SNHL that characterizes the sudden loss of hearing, usually in one ear and affects an estimated 5-27/100,000 persons per year (Alexander and Harris, 2013 ; Lin et al, 2017 ).…”

Section: Pde Mutations and Hearing Lossmentioning

confidence: 99%

An Update on Phosphodiesterase Mutations Underlying Genetic Etiology of Hearing Loss and Retinitis Pigmentosa

et al. 2018

View full text Add to dashboard Cite

Section: Pde Mutations and Hearing Lossmentioning

confidence: 99%

An Update on Phosphodiesterase Mutations Underlying Genetic Etiology of Hearing Loss and Retinitis Pigmentosa

et al. 2018

View full text Add to dashboard Cite

“…Lin et al . 13 observed ABR changes in 102 sudden SNHL patients. The mean latencies of ABR waves 1, 3, and 5 were significantly increased on the affected side, and the latency of wave 1 was significantly correlated with hearing outcome.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the relationship between changes in the auditory brainstem response and prognosis in patients with sudden hearing loss

et al. 2019

View full text Add to dashboard Cite

ObjectiveTo analyse how the auditory brainstem response changes in patients with sudden sensorineural hearing loss.MethodData were collected via retrospective medical chart review.ResultsForty-three patients were included in this study. The mean latency of auditory brainstem response wave 1 was significantly longer for the affected side than for the unaffected side (p = 0.003). The mean latency of auditory brainstem response wave 1 was significantly shorter, and the mean amplitude of auditory brainstem response wave 1 was significantly larger, in the good response group compared to the poor response group. In forward conditional logistic regression analysis, auditory brainstem response wave 1 latency was an independent predictor of a good response (odds ratio = 34.37, 95 per cent confidence interval = 1.56–757.15, p = 0.025).ConclusionIn patients with sudden sensorineural hearing loss, the latency of wave 1 of the auditory brainstem response was significantly increased and was related to prognosis.

show abstract

“…ABR and DPOAE tests are usually done sequentially and information from both tests provide useful diagnostic insight in determining cochlear function. An abnormal ABR but a normal DPOAE suggests neural or post‐cochlear pathology, whereas an abnormal result in both ABR and DPOAE suggest sensory hearing loss from outer hair cell dysfunction (Lin et al, ; Profant et al, ). In the present study, there was no statistical significant difference in hearing thresholds of BM‐MSCs treated, PBS injected and control untreated animals.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we determined the effect of BM-MSCs on cochlear hearing function and inner ear morphology employing a rat model without immunosuppression. ABRs and DPOAEs are well-accepted techniques to determine hearing thresholds in experimental animal models and human subjects (Lin et al, 2017;Nowotny et al, 2017;Profant et al, 2017;Yang et al, 2017). ABR is an evoked potential from auditory stimuli and recorded from an electrode implanted under the skin on the scalp or earlobe to measure the function of cranial nerve VIII (auditory nerve).…”

Section: Discussionmentioning

confidence: 99%

Effect of Bone Marrow‐Derived Mesenchymal Stem Cells on Cochlear Function in an Experimental Rat Model

Mittal

Ocak

Zhu

et al. 2019

The Anatomical Record

View full text Add to dashboard Cite

Mesenchymal stem cell (MSC) therapy is an emerging treatment modality for various human diseases. Although induced pluripotent stem cells have been explored for the restoration of hearing, the potential of MSCs as a therapeutic strategy for various cochlear insults is not precisely known. MSCs possess anti‐inflammatory, anti‐apoptotic and neuroprotective properties, making them an attractive target for the treatment of inner ear disorders such as hair cell damage in response to inflammation. Most of the previous studies have used immunosuppression or the complex surgical techniques to deliver stem cells into the cochlea. However, no information is available regarding the biocompatibility and safety of MSCs in the inner ear in immunocompetent cochlea. The aim of the present study was to determine the effect of non‐surgical administration of rodent bone marrow derived MSCs (BM‐MSCs) through transtympanic delivery on the cochlear function and to assess any adverse effects on the auditory system employing a rat model without immunosuppression. We observed that the transtympanic administration of BM‐MSCs has no significant effect on the hearing thresholds as determined by auditory brainstem response and distortion product otoacoustic emissions. Histopathological examination revealed no recruitment of inflammatory leukocytes and edema in the cochlea of BM‐MSCs administrated rats. The results of this study suggest that transtympanic administration of BM‐MSCs is safe and can be explored in providing otoprotection against cochlear insults. Anat Rec, 303:487–493, 2020. © 2019 American Association for Anatomy

show abstract

Correlation between auditory brainstem response and hearing prognosis in idiopathic sudden sensorineural hearing loss patients

Cited by 14 publications

References 18 publications

An Update on Phosphodiesterase Mutations Underlying Genetic Etiology of Hearing Loss and Retinitis Pigmentosa

An Update on Phosphodiesterase Mutations Underlying Genetic Etiology of Hearing Loss and Retinitis Pigmentosa

Analysis of the relationship between changes in the auditory brainstem response and prognosis in patients with sudden hearing loss

Effect of Bone Marrow‐Derived Mesenchymal Stem Cells on Cochlear Function in an Experimental Rat Model

Contact Info

Product

Resources

About