Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study

Li, Hong; Han, Yu; Deng, Chenlong; Chen, Aihua

doi:10.1186/s12872-022-02877-2

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Results from a large-scale nationwide population cohort study carried on in the Republic of Korea showed that AIP HRs for CVD risk were higher as compared to HRs of triglycerides and HDL cholesterol when those variables were applied in the regression model alone (42). Whereas, a study performed among 1,131 male patients with angiographically diagnosed CAD and without CAD found that the AIP predictive value for diagnosing CAD was not significantly different as compared with traditional blood lipids (43). Our results have shown a positive association between increasing values of AIP and risk of CVD mortality after adjustment to many confounders in men but not women responders.…”

Section: Discussionmentioning

confidence: 96%

Predictive importance of the visceral adiposity index and atherogenic index of plasma of all-cause and cardiovascular disease mortality in middle-aged and elderly Lithuanian population

Tamošiūnas

Lukšienė

Krančiukaitė-Butylkinienė

et al. 2023

Front. Public Health

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BackgroundTwo indices: visceral adiposity index (VAI) and atherogenic index of plasma (AIP) during several recent years were implemented into epidemiological studies for predicting of cardiovascular diseases (CVD) and mortality risk. Our study aimed to evaluate the association of VAI and AIP with the risk of all-cause and CVD mortality among the Lithuanian urban population aged 45–72 years.MethodsIn the baseline survey (2006–2008), 7,115 men and women 45–72 years of age were examined within the framework of the international study Health, Alcohol and Psychosocial Factors in Eastern Europe (HAPIEE). Six thousand six hundred and seventy-one participants (3,663 women and 3,008 men) were available for statistical analysis (after excluding 429 respondents with the missed information on study variables) and for them, VAI and AIP were calculated. The questionnaire evaluated lifestyle behaviors, including smoking and physical activity. All participants in the baseline survey were followed up for all-cause and CVD mortality events until December 31st, 2020. Multivariable Cox regression models were applied for statistical data analysis.ResultsAfter accounting for several potential confounders, higher levels of VAI (compared 5th quintile to 1st quintile) were associated with significantly higher CVD mortality in men [Hazards ratio (HR) = 1.38] and all-cause mortality in women (HR = 1.54) after 10-year follow-up. CVD mortality significantly increased in men with 0 the highest AIP quintile compared with that for the lowest quintile (HR = 1.40). In women, all-cause mortality was significantly higher for the 4th quintile of AIP as compared with the 1st quintile (HR = 1.36).ConclusionsHigh-risk VAI levels were statistically significantly associated with all-cause mortality risk in men and women groups. The higher AIP level (5th quintile vs. 1st quintile—in men and 4th quintile vs. 1st quintile—in women) was significantly associated with increased mortality from CVD in the men group and increased all-cause mortality in the women group.

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Section: Discussionmentioning

confidence: 96%

Predictive importance of the visceral adiposity index and atherogenic index of plasma of all-cause and cardiovascular disease mortality in middle-aged and elderly Lithuanian population

Tamošiūnas

Lukšienė

Krančiukaitė-Butylkinienė

et al. 2023

Front. Public Health

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“…Similarly, there was no significant association between AIP and CAD in elderly females aged ≥ 65 years [ 33 ]. Moreover, AIP could not predict the presence of CAD in elderly males who underwent coronary angiography [ 34 ]. A possible explanation to address this finding is that AIP level is increased in elderly population [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

The association of atherogenic index of plasma with cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis

Rabiee Rad,

Ghasempour Dabaghi,

Darouei

et al. 2024

Cardiovasc Diabetol

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Background Atherogenic index of plasma (AIP) represents a novel marker in the current era of cardiovascular diseases. In this meta-analysis, we aimed to evaluate the association of AIP with cardiovascular prognosis in patients with coronary artery disease (CAD). Methods PubMed, Scopus, and Web of Science databases were searched from inception through 2024. The primary outcome was major cardiovascular events (MACE). The secondary outcomes included all-causes death, cardiovascular death, myocardial infarction (MI), stroke, revascularization, and no-reflow phenomenon. AIP was determined by taking the logarithm of the ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C). The data analysis was represented using the risk ratio (RR) along with a 95% confidence interval (CI). Results Sixteen studies with a total number of 20,833 patients met the eligible criteria. The pooled-analysis showed a significant increased risk of MACE in the highest AIP group compared with the lowest AIP group (RR = 1.63; 95% CI, 1.44–1.85; P < 0.001). A similar result was observed when AIP was regarded as a continuous variable (RR = 1.54; 95% CI, 1.30–1.83; P < 0.001). Besides, elevated AIP was associated with increased risk of cardiovascular death (RR = 1.79; 95% CI, 1.09–2.78; P = 0.02), MI (RR = 2.21; 95% CI, 1.55–3.13; P < 0.001), revascularization (RR = 1.62; 95% CI, 1.34–1.97; P < 0.001), no-reflow phenomenon (RR = 3.12 95% CI, 1.09–8.96; P = 0.034), and stent thrombosis (RR = 13.46; 95%CI, 1.39-129.02; P = 0.025). However, AIP was not significantly associated with the risk of all-causes death and stroke among patients with CAD. Conclusions The results of this study demonstrated that increased AIP is an independent prognostic factors in patients with CAD. Further research is warranted to elucidate the potential development of targeted interventions to modify AIP levels and improve patient outcomes.

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“…In numerous studies the atherogenicity of blood serum is measured based on blood lipid parameters and age-related changes in atherogenicity index were demonstrated. In particular, it was shown that blood levels of total cholesterol, LDL, and triglyceride as well as plasma atherogenic index decreased with age in patients with ischemic heart disease (Hong et al, 2022). The other study of the association between plasma atherogenic index and risk of myocardial infarction demonstrated that a high plasma atherogenic index calculated as a ratio of blood triglycerides and HDL led to a greater risk of myocardial infarction in younger patients (Zhang et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

The Association of Blood Serum Atherogenicity with Risk Factors for Cardiovascular Disease

Kirichenko,

Sobenin

et al. 2024

OnLine Journal of Biological Sciences

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Cardiovascular Diseases (CVD) caused by atherosclerosis are the most frequent cause of mortality worldwide, so the identification of new biomarkers of atherosclerosis development is quite actual. The atherogenicity of blood serum is considered as the potential of human serum to cause cholesterol accumulation in primary culture macrophages. The current study aimed to evaluate the association of the atherogenicity of blood serum with conventional cardiovascular risk factors to assess its potential in CVD prognosis. Serum atherogenicity was measured in 815 study CVD-free participants at baseline and at the follow-up visit after 5 years. 51% of study participants had atherogenic serum at baseline, but at the follow-up visit after 5 years atherogenicity increased significantly in 60% of participants. An increase of atherogenicity was observed in the group with non-atherogenic serum at baseline, p<0.001. The correlation of serum atherogenicity with plasma lipids level, i.e., total cholesterol and LDL, was demonstrated. There was a negative correlation between changes in the potential of blood serum to induce cholesterol accumulation in primary culture macrophages and the age of study participants (r = -0.089, p = 0.011). In groups with decreased and unchanged atherogenicity, the increase of statin administration, as well as amelioration of lipids profile, were revealed after a 5-year follow-up. Thus, the atherogenicity of blood serum may be considered a promising marker in the prognosis of CVD development, but further research is needed to evaluate the prognostic value of serum atherogenicity.

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Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study

Cited by 5 publications

References 26 publications

Predictive importance of the visceral adiposity index and atherogenic index of plasma of all-cause and cardiovascular disease mortality in middle-aged and elderly Lithuanian population

Predictive importance of the visceral adiposity index and atherogenic index of plasma of all-cause and cardiovascular disease mortality in middle-aged and elderly Lithuanian population

The association of atherogenic index of plasma with cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis

The Association of Blood Serum Atherogenicity with Risk Factors for Cardiovascular Disease

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