Correlation between Arterial Lactate and Central Venous Lactate in Children with Sepsis

Sarmiento, Jaime Fernández; Araque, Paula; Yepes, M. J.; Mulett, Hernando; Tovar, Ximena; Rodríguez, Fabio

doi:10.1155/2016/7839739

Cited by 5 publications

(5 citation statements)

References 10 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies attempted to analyse correlation between AL and venous lactate levels. However, these studies did not establish an agreement between the two 6‐12 . It is our opinion that identifying the level of agreement between AL and venous lactate is crucial in deciding whether or not venous blood samples can be used as surrogate for arterial blood samples.…”

Section: Discussionmentioning

confidence: 93%

“…However, these studies did not establish an agreement between the two. [6][7][8][9][10][11][12] It is our opinion that identifying the level of agreement between AL and venous lactate is crucial in deciding whether or not venous blood samples can be used as surrogate for arterial blood samples. In our study, we established the correlation between AL and venous lactate with a high degree of agreement between them.…”

Section: Ta B L E 1 Patient Characteristics At Baseline and Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

The agreement between arterial and venous lactate in patients with sepsis

et al. 2021

View full text Add to dashboard Cite

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host response to infection. Mismatch between oxygen supply and demand results in tissue hypoperfusion and hypoxia, leading to anaerobic metabolism and lactate production. 1 The importance of lactate levels for the diagnosis, prognostication, risk stratification and guidance to treatment is well established. 2 Thus, lactate is a defining criterion for sepsis and septic shock, and a key resuscitation target in the Surviving Sepsis Campaign guidelines and in sepsis management bundles worldwide.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Ta B L E 1 Patient Characteristics At Baseline and Outcomesmentioning

confidence: 99%

The agreement between arterial and venous lactate in patients with sepsis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It is important to note that it offers deeper understanding of the proposed hypothesis, but depends on robust data and prior knowledge. This type of metabolomics uses triple quadrupole mass spectrometry ( 50 , 51 ) and is a highly sensitive method for the absolute quantification of metabolites, with a very low concentration. On the other hand, the nonspecific metabolomic approach is an unbiased screening method for identifying thousands of metabolites in a single sample, thus enabling exploratory studies of currently unknown metabolites ( 38 ).…”

Section: Metabolomics In Sepsismentioning

confidence: 99%

Endothelial Damage in Sepsis: The Importance of Systems Biology

et al. 2022

View full text Add to dashboard Cite

The early diagnosis and appropriate stratification of sepsis continues to be one of the most important challenges in modern medicine. Single isolated biomarkers have not been enough to improve diagnostic and prognostic strategies and to progress toward therapeutic goals. The information generated by the human genome project has allowed a more holistic approach to the problem. The integration of genomics, transcriptomics, proteomics and metabolomics in sepsis has allowed us to progress in the knowledge of new pathways which are pathophysiologically involved in this disease. Thus, we have understood the importance of and complex interaction between the inflammatory response and the endothelium. Understanding the role of important parts of the microcirculation, such as the endothelial glycocalyx and its interaction with the inflammatory response, has provided early recognition elements for clinical practice that allow the rational use of traditional medical interventions in sepsis. This comprehensive approach, which differs from the classical mechanistic approach, uses systems biology to increase the diagnostic and prognostic spectrum of endothelial damage biomarkers in sepsis, and to provide information on new pathways involved in the pathophysiology of the disease. This, in turn, provides tools for perfecting traditional medical interventions, using them at the appropriate times according to the disease's pathophysiological context, while at the same time discovering new and improved therapeutic alternatives. We have the challenge of transferring this ideal scenario to our daily clinical practice to improve our patients' care. The purpose of this article is to provide a general description of the importance of systems biology in integrating the complex interaction between the endothelium and the inflammatory response in sepsis.

show abstract

“…4,5 Sepsis is treatable and early recognition of the impairment of various organs, especially cardiovascular injury, is essential for improving the outcomes. 6–10…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Glycocalyx Injury and Endothelial Activation are Associated with Clinical Outcomes in Patients with Sepsis: A Systematic Review and Meta-Analysis

Fernández‐Sarmiento

Molina

Salazar-Peláez

et al. 2022

J Intensive Care Med

Self Cite

View full text Add to dashboard Cite

Objective Sepsis is one of the main causes of morbidity and mortality worldwide. Microcirculatory impairment, especially damage to the endothelium and glycocalyx, is often not assessed. The objective of this systematic review and meta-analysis was to summarize the available evidence of the risk of unsatisfactory outcomes in patients with sepsis and elevated glycocalyx injury and endothelial activation biomarkers. Design A systematic search was carried out on PubMed/MEDLINE, Embase, Cochrane and Google Scholar up to December 31, 2021, including studies in adults and children with sepsis which measured glycocalyx injury and endothelial activation biomarkers within 48 hours of hospital admission. The primary outcome was the risk of mortality from all causes and the secondary outcomes were the risk of developing respiratory failure (RF) and multiple organ dysfunction syndrome (MODS) in patients with elevations of these biomarkers. Measurements and Main Results A total of 17 studies (3,529 patients) were included: 11 evaluated syndecan-1 (n=2,397) and 6 endocan (n=1,132). Syndecan-1 was higher in the group of patients who died than in those who survived [255 ng/mL (IQR: 139-305) vs. 83 ng/mL (IQR:40-111); p=0.014]. Patients with elevated syndecan-1 had a greater risk of death (OR 2.32; 95% CI 1.89, 3.10: p<0.001), MODS (OR 3.3; 95% CI 1.51, 7.25: p=0.003;), or RF (OR 7.53; 95% CI 1.86-30.45: p=0.005). Endocan was higher in patients who died [3.1 ng/mL (IQR 2.3, 3.7) vs. 1.62 ng/mL (IQR 1.2, 5.7); OR 9.53; 95% CI 3.34, 27.3; p<0.001], who had MODS (OR 8.33; 95% CI 2.07, 33.58; p=0.003) and who had RF (OR 9.66; 95% CI 2.26, 43.95; p=0.002). Conclusion Patients with sepsis and abnormal glycocalyx injury and endothelial activation biomarkers have a greater risk of developing respiratory failure, multiple organ failure, and death. Microcirculatory impairment should be routinely evaluated in patients with sepsis, using biomarkers to stratify risk groups.

show abstract

Correlation between Arterial Lactate and Central Venous Lactate in Children with Sepsis

Cited by 5 publications

References 10 publications

The agreement between arterial and venous lactate in patients with sepsis

The agreement between arterial and venous lactate in patients with sepsis

Endothelial Damage in Sepsis: The Importance of Systems Biology

Biomarkers of Glycocalyx Injury and Endothelial Activation are Associated with Clinical Outcomes in Patients with Sepsis: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About