The agreement between arterial and venous lactate in patients with sepsis

Jose, Joyes Mary; Cherian, Anusha; Bidkar, Prasanna Udupi; Mohan, VK

doi:10.1111/ijcp.14296

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…In severe cases, patients may have adverse symptoms, such as septic shock and multiple organ failure. This will seriously threaten the life and health of patients [ 2 ]. Therefore, early judgment and accurate evaluation of clinical sepsis can play a positive role in improving the prognosis and quality of life of patients [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

Jiang

Wang

et al. 2022

Contrast Media & Molecular Imaging

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In order to explore the effective markers of presepsis in the prediction of clinical disease and disease severity, the predictive effect of lactic acid (Lac) combined with cardiac troponin T (cTnT) and 5-hydroxytryptophan (5-HT) on the severity of sepsis in intensive care unit (ICU) patients and its correlation with prognosis is investigated. A total of 85 sepsis patients admitted to the ICU of our hospital from January 2020 to June 2021 are selected to establish the ICU sepsis group, and 72 health examination patients who received physical examination in our hospital during the same period are included in the healthy control group. The experimental results demonstrate that combined detection mode of serum Lac, cTnT, and 5-HT indicators has a high predictive value for the condition of patients with ICU sepsis and those indicators are closely correlated with the prognosis of patients. It suggests that the follow-up clinical monitoring of serum Lac, cTnT, and 5-HT indicators for patients with ICU sepsis can evaluate their condition and improve and optimize the clinical diagnosis and treatment plan effectively.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

Jiang

Wang

et al. 2022

Contrast Media & Molecular Imaging

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“…Arterial blood is the preferred sample for lactate measurement because it is derived from mixed venous blood and thus provides a representative sum of all sources of tissue lactate production. 39 Capillary blood, which is more easily obtained, is an alternative sample employed for lactate determination. In healthy volunteers or intensive care human patients, capillary lactate measurements were 47% higher than arterial blood lactate when sampled at the fingertip.…”

Section: Discussionmentioning

confidence: 99%

Admission lactate concentration has predictive value for death or severe complications within 30 days after admission in cattle with long-bone fractures

Constant

Marchionatti

Desrochers

et al. 2023

javma

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OBJECTIVE To determine the prognostic value of lactate concentration measurements at admission in cattle with long-bone fractures. ANIMALS 43 cattle with long-bone fractures between July 2016 and Dec 2018. PROCEDURES In this prospective cohort study, lactate concentration was measured in systemic venous blood and locally in capillary blood sampled from the fractured and contralateral limbs of cattle and assessed for outcome prediction. The cutoff value was determined by maximizing the Youden index from receiver-operating characteristic curves. Multivariable logistic regression was employed to verify whether higher lactate concentrations compared with the cutoff value were an independent risk factor for poor outcomes at 30 days or 3 years after admission. RESULTS Poor outcome was associated with higher capillary lactate concentration in the fractured limb (P < .001) and greater difference with systemic blood (P = .005). A cutoff value of lactate difference ≥ 2.4 mmol/L (sensitivity = 0.80; specificity = 0.965) between capillary lactate in the fractured limb and systemic blood was the best predictor of death ≤ 30 days after admission (P < .001). Multivariable analysis revealed that this cutoff value was an independent risk factor for 30-day and 3-year outcomes (P < .001). CLINICAL RELEVANCE Admission blood lactate concentration difference ≥ 2.4 mmol/L between the fractured limb and systemic blood was a robust and independent predictor of outcome for cattle of the present report. Lactate metabolism is locally impaired in fractured limbs of nonsurviving or at higher complication risk cattle, which may help identify patients at high risk for poor outcomes.

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“…A study of the correlation between ScvO 2 and the adverse prognosis of septic shock demonstrated that ScvO 2 levels were not associated with poor outcomes [29,30]. The importance of lactate levels for the diagnosis, prognostication, risk strati cation and guidance to treatment is well established [31].…”

Section: Discussionmentioning

confidence: 99%

Lactate kinetics-oriented fluid resuscitation Strategy for lowering the application of catecholamine of septic shock in children

Wang,

Zhang

et al. 2023

Preprint

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Sepsis is a leading cause of mortality for children wordwide. Some studies suggested that initial hyperlactacidemia and central venous oxygen saturation (ScvO2) are associated with mortality in sepsis. Our objective was to compare whether SCVO2-oriented resuscitation strategies and lactate kinetics oriented resuscitation strategies differ in mortality in children with septic shock. 250 children diagnosed with septic shock between January 2017 and October 2021 were enrolled in this study, and they were randomly assigned to two groups, ScvO2-oriented group (n = 125) and lactate kinetics-oriented group (n = 125). The Trial Registration Number was 20230068 and the date of registration was June 1, 2023. The primary endpoint was the 28-day mortality, and the secondary endpoints included the mechanical ventilation time, 6 h and 12 h success rate of the resuscitation, intensive care unit (ICU) and hospital stay time, the vasoactive inotropic score (VIS) and rate of arrhythmia. There were no significant differences in baseline data and 28-day mortality between the two groups. However, the norepinephrine(NE) dose was lower in the lactate kinetics-oriented group than that in the ScvO2-oriented group at both the 2nd and 3rd day. 6 h success rate of the resuscitation in the lactate kinetics-oriented group was significantly higher than that in the ScvO2 -oriented group (P = 0.037). Conclusions: Compared with the ScvO2-oriented group, the lactate kinetics-oriented group could improve the success rate of the resuscitation in the early stages of septic shock and reduce the application of catecholamine.

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The agreement between arterial and venous lactate in patients with sepsis

Cited by 5 publications

References 19 publications

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

Admission lactate concentration has predictive value for death or severe complications within 30 days after admission in cattle with long-bone fractures

Lactate kinetics-oriented fluid resuscitation Strategy for lowering the application of catecholamine of septic shock in children

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