Correlation between antitumor activity, molecular weight, and conformation of lentinan

Zhang, Lina; Li, Xuelian; Xu, Xiaojuan; Zeng, Fanbo

doi:10.1016/j.carres.2005.02.032

Cited by 284 publications

(138 citation statements)

References 38 publications

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“…2 and 3). The antitumor activity of β -glucans is known and has been reported in several studies with fungal (1 3),(1 6)-β -glucan, such as shizophylan, lentinam (Ooi and Liu 2000;Zhang et al 2005), (1 3),(1 6)-β -glucan from yeast (Kiho et al 1998). It can be explained that after implantation of tumor cells naturally elicited antitumor antibodies most probably occur, and they function similarly to exogenous antitumor mAbs by coating tumor cells with iC3b fragments (Hong et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Potentiating Effect of .BETA.-Glucans on Photodynamic Therapy of Implanted Cancer Cells in Mice

Akramienė¹,

Aleksandraviciene

Grazeliene

et al. 2010

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

Potentiating Effect of .BETA.-Glucans on Photodynamic Therapy of Implanted Cancer Cells in Mice

Akramienė¹,

Aleksandraviciene

Grazeliene

et al. 2010

Tohoku J. Exp. Med.

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“…Accordingly the tumor inhibitory rates of the PD groups were 36.67%, 44.80% and 51.79%, which exerted significant inhibition of the H22 hepatoma growth in a dose-dependent manner. Moreover, tumor growth was frequently accompanied by an immunosuppression regardless of tumor location and aetiology (Zhang et al, 2005). A wide variety of compounds capable of elevating the immune functions and inducing malignant cell death without affecting their normal organisms have been shown to exert therapeutic effects in the treatment of cancer (Yang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis

Tian

Liu

et al. 2016

J. Toxicol. Sci.

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-Platycodin D (PD), a major saponin derived and isolated from the roots of Platycodon grandiflorum, exerts potent growth inhibition and strong cytotoxicity against various cancer cell lines. However, the anti-tumor efficacy of PD on H22 hepatocellular carcinoma remains unknown. In the present study, we aimed to explore the anti-hepatoma activity in vivo and the underlying mechanism of PD in H22 tumor-bearing mice. The results revealed that PD could considerably suppress tumor growth with no significant side effects on immune organs and body weight. Further investigations showed that the levels of serum cytokines, including interferon gamma (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-2 (IL-2), were enhanced by PD administration. On the other hand, PD inhibited the production of vascular endothelial growth factor (VEGF) in serum of H22 tumor mice. Additionally, the observations from H&E and Hoechst 33258 staining results demonstrated that PD noticeably induced apoptosis in H22 hepatocellular carcinoma cells. Importantly, immunohistochemical analysis showed that PD treatment increased Bax expression and decreased Bcl-2 and VEGF expression of H22 tumor tissues in a dose-dependent manner. Taken together, the findings in the present investigation clearly demonstrated that the PD markedly suppressed the tumor growth of H22 transplanted tumor in vivo at least partly via improving the immune functions, inducing apoptosis, and inhibiting angiogenesis.

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“…Zhang et al (2005) obtiveram misturas oligossacarídicas de diferentes massas moleculares mantendo a estrutura química e conformação nativa da esquizofilana, uma β-(1→3; 1→6)-glucana produzida pelo fungo Schizophyllum commune, através da degradação por irradiação ultra-sônica de alta energia.…”

Section: Obtenção De Oligossacarídeos Por Métodos Físicos E Químicosunclassified

Produção, propriedades e aplicações de oligossacarídeos

et al. 2011

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ResumoOs oligossacarídeos participam da constituição da fibra alimentar e são principalmente utilizados como prebióticos. Esta revisão apresenta as vias de obtenção destes açúcares, os quais podem ser produzidos por síntese (química ou enzimática) ou da despolimerização de polissacarídeos (física, química ou enzimática), como descrito na presente revisão. Os oligossacarídeos vêm sendo utilizados comercialmente como ingredientes de cosméticos, medicamentos, produtos agrícolas e principalmente na indústria alimentícia. O potencial de aplicações dos oligossacarídeos nessas áreas nas mais diversas áreas tais como alimentos, rações animais, fármacos e cosméticos tem contribuído para o aumento das investigações científicas. O uso de oligossacarídeos como agentes imunomoduladores e modificadores de respostas biológicas foi recentemente descrito, assim como seus efeitos como compostos antiinflamatórios e hipocolesterolêmicos. Uma visão geral sobre as diversas funções nutracêuticas e biológicas destes oligômeros de carboidratos visando benefícios para a saúde humana também foi reportada. Palavras-chave: Oligossacarídeos. Fibras da dieta. Saúde humana. AbstractOligosaccharides participate in the formation of dietary fiber and are mainly used as prebiotic agents. This review presents ways of obtaining these sugars, which can be produced by synthesis (chemical or enzymatic), or through depolymerization of polysaccharides (physical, chemical or enzymatic). Oligosaccharides have also been used commercially as an ingredient in cosmetics, pharmaceuticals, agricultural products and especially in the food industry because of their physical properties. The potential applications of oligosaccharides in several areas such as food, animal feed, pharmaceuticals and cosmetics have contributed to the increase in scientific research on these carbohydrates. The use of oligosaccharides as immuno-modulatory agents and biological response modifiers has been recently described, and their effects as anti-inflammatory and in reducing cholesterol. An overview of the various nutraceutical and biological functions of these carbohydrates in order to benefit human health is also reported.

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Correlation between antitumor activity, molecular weight, and conformation of lentinan

Cited by 284 publications

References 38 publications

Potentiating Effect of .BETA.-Glucans on Photodynamic Therapy of Implanted Cancer Cells in Mice

Potentiating Effect of .BETA.-Glucans on Photodynamic Therapy of Implanted Cancer Cells in Mice

Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis

Produção, propriedades e aplicações de oligossacarídeos

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