Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

Pu, Hao-Jie; Cao, Yun‐Feng; He, Rong‐Rong; Zhao, Zhihui; Song, Jinhui; Jiang, Bin; Huang, Ting; Tang, Shu-Hong; Lu, Jian-min; Kojima, Hiroshi

doi:10.1155/2012/161062

Cited by 13 publications

(4 citation statements)

References 22 publications

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“…According to the above contents, it is not difficult to find that lignans can activate the Nrf2 signaling pathway and enhance the expression of HSPs to play an antioxidant role. In addition, it was reported that lignans (100 and 200 mg/kg) isolated from SC could prevent excessive production and accumulation of free radicals in hepatocytes [185] . Schidandrin B (0.04 mmol/kg) can directly eliminate ROS and enhance the antioxidant defense system [186] .…”

Section: Othersmentioning

confidence: 99%

Lignans are the main active components of Schisandrae ChinensisFructus for liver disease treatment: a review

Fu,

Dai,

et al. 2023

Food Science and Human Wellness

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As a traditional Chinese herbal medicine, Schisandrae Chinensis Fructus (SC) has been used in medicine and food industry due to its health care and therapeutic effects. Over the past 20 years, the use of SC and its active ingredient lignans in the prevention and treatment of liver diseases has been increasing, and their hepatoprotective effects has increased the interest of the public and academia. Therefore, in the present work, we first determined the effectiveness of SC in the treatment of liver diseases such as metabolic associated fatty liver disease, alcoholic liver disease, cholestatic liver disease and acute liver injury. Subsequently, the pharmacological effects and molecular mechanisms of lignans, the active components of SC, for liver disease treatment were comprehensively summarized for the first time. The results showed that the lignans in SC could achieve hepatoprotective effects by regulating lipid metabolism, anti-fibrosis, anti-inflammation, anti-oxidation, anti-tumor and regulating bile acid metabolism. The mechanism mainly involved adenosine 5'-monophosphate-activated protein kinase, endoplasmic reticulum stress, sterol regulatory element binding protein 1c, autophagy, transforming growth factor-β, mitogen-activated protein kinase, microRNA, nuclear factor kappa-B, nuclear factor erythroid-2-related factor 2, heat shock proteins and pregnane X receptor signaling pathways. These results can lay a scientific foundation for the development of hepatoprotective drugs or functional foods from SC/lignans.

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Section: Othersmentioning

confidence: 99%

Lignans are the main active components of Schisandrae ChinensisFructus for liver disease treatment: a review

Fu,

Dai,

et al. 2023

Food Science and Human Wellness

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“…In China since the XVI century this plants has belonged to the first category of drugs recommended for restoration of vitality. According to modern research, the biologically active compounds of S. chinensis have anticancer, antimicrobial action, improve the functioning of the pancreas, stimulate insulin secretion, and prevent complications in diabetic diseases (Panossian, 2008;Venkanna et al, 2014;Lv et al, 2015;Nowak et al, 2019), as well as showing hepatoprotective effects (Pu et al, 2012) and antiviral activity (Li & Peng, 2013).…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of the distribution of assimilates in the organs of Schisandra chinensis plants under different soil and climatic conditions

et al. 2022

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Peculiarities of accumulation of nutrients in the leaves of Schisandra chinensis (Turcz.) Baill. and rhizosphere soil under the conditions of its continuous monoculture have been studied. Comparative analysis of the distribution of nutrients in the leaves of plants under different soil and climatic conditions revealed significant differences. It was found that plants grown on podzolic chernozem of Kolomyia State Forest Fund (Otyniia, Ukraine) were characterized by more intensive absorption of such nutrients as Ca, Si, P, Cu, Zn and Mg. The content of P, K, S, Mn was much higher in the foliar tissues of S. chinensis plants cultivated on the territory of the M. Gryshko National Botanical Garden (Kyiv, Ukraine) in the conditions of dark grey forest soil. The high ability of plants to accumulate and release Mg into the rhizosphere soil was revealed, which is fully consistent with the selective ability of plants to release mineral elements into the soil environment in accordance with their ecomorphotypes. At the same time, the amount of Ca in the rhizosphere soil decreased significantly at the end of the vegetative period, which could be explained, on the one hand, by the intensive influx of Ca into plant tissues and, on the other hand, by participation in chemical balancing processes to reduce manganese and nitrogen mobility in the soil. Barrier-free accumulation of Fe, Ca, Mg, Al elements in S. chinensis leaves was revealed, which should be taken into account when developing plant cultivation technology. The studies of allelopathy activity of vegetative and generative organs of plants and rhizosphere soil have shown that phenolic substances accumulate in small amounts in the soil under S. chinensis, which is a prerequisite for successful cultivation of this fruit vine in the Forest-Steppe zone of Ukraine under conditions of continuous long-term cultivation. The largest amount of phenolic substances was in the upper soil horizons, which gradually decreased with depth, which is consistent with the course of redox processes for the studied soil profiles. The pool of free amino acids of S. chinensis plants growing in different soil and climatic conditions was analyzed, the concentration of amino acids in the leaves was the most indicative. Evaluation of the quantitative and qualitative distribution of free amino acids in plant tissues serves as a diagnostic sign of plant sensitivity to soil and climatic conditions.

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“…Schisandra chinensis ( S. chinensis ) is a traditional Chinese herbal medicine that has been used for the treatment of viral and chemical liver injury in Asia for thousands of years [ 16 – 18 ]. The lignans as the main active ingredients in S. chinensis have various pharmacological effects such as antioxidative, anti-inflammatory, antitumor, and hepatoprotective activities [ 18 , 19 ]. It was reported that S. chinensis exerted its effect against chemical-induced liver injury by regulating the antioxidation function and heat shock proteins [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Schisandra Lignan Extract Protects against Carbon Tetrachloride‐Induced Liver Injury in Mice by Inhibiting Oxidative Stress and Regulating the NF‐κB and JNK Signaling Pathways

Chen

Zhan

Liu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Schisandra chinensis (S. chinensis) is a traditional Chinese herbal medicine widely used for the treatment of liver disease, whose main active components are lignans. However, the action mechanisms of the lignans in S. chinensis remain unclear. This study aimed to investigate the protective effect and related molecular mechanism of Schisandra lignan extract (SLE) against carbon tetrachloride- (CCl4-) induced acute liver injury in mice. Different doses of SLE at 50, 100, and 200 mg/kg were administered daily by gavage for 5 days before CCl4 treatment. The results showed that SLE significantly decreased the activities of serum ALT/AST and reduced liver pathologic changes induced by CCl4. Pretreatment with SLE not only decreased the content of MDA but increased SOD, GSH, and GSH-Px activities in the liver, suggesting that SLE attenuated CCl4-induced oxidative stress. The expression levels of inflammatory cytokines TNF-a, IL-1β, and IL-6 were decreased after oral administration of SLE, probably because lignans inhibited the NF-κB activity. Additionally, SLE also inhibited hepatocyte apoptosis by suppressing JNK activation and regulating Bcl-2/Bax signaling pathways. In conclusion, these results suggested that SLE prevented CCl4-induced liver injury through a combination of antioxidative stress, anti-inflammation, and antihepatocyte apoptosis and alleviated inflammation and apoptosis by regulating the NF-κB, JNK, and Bcl-2/Bax signaling pathways.

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Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

Cited by 13 publications

References 22 publications

Lignans are the main active components of Schisandrae ChinensisFructus for liver disease treatment: a review

Lignans are the main active components of Schisandrae ChinensisFructus for liver disease treatment: a review

Peculiarities of the distribution of assimilates in the organs of Schisandra chinensis plants under different soil and climatic conditions

Schisandra Lignan Extract Protects against Carbon Tetrachloride‐Induced Liver Injury in Mice by Inhibiting Oxidative Stress and Regulating the NF‐κB and JNK Signaling Pathways

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