Correlation between an ABO Blood Group and Primary Femoral Head Necrosis: A Case–Control Study

Abstract

Objective: To investigate the relationship between primary femoral head necrosis (ONFH) and an ABO blood group.Methods: This study was a retrospective case-control trial. An analysis of the clinical data of an ABO blood group with 516 patients (case group) with ONFH and 489 limb-fracture patients (control group) without previous hip pain was obtained from the Second Hospital of Shanxi Medical University from November 2015 to November 2018. The clinical data included gender, age, height, weight, a history of smoking, alcohol abuse, prior medical history, hormone use, and ABO blood type. A logistic regression model was used for univariate and multivariate analysis.Results: From November 2015 to November 2018, there were 267 males and 249 females in the 516 cases of ONFH in the case group. The control group included 289 males and 200 females. In terms of age, the average age of the case group was significantly lower than that of the control group. In terms of body mass index (BMI), the BMI of the case group was significantly higher than that of the control group (P < 0.05). From the previous medical history of patients in the two groups (coronary heart disease, hypertension, cerebrovascular disease, diabetes, and peripheral vascular disease), there was no significant difference between the two groups from a statistical perspective (P < 0.05). However, according to the risk factors of ONFH (smoking, alcohol abuse, hyperlipidemia, and hormone-use history), there were significant differences between the case group and the control group. There was no statistical difference in the quantitative distribution ratio of the four blood types -A, B, O, and ABbetween the case group and the control group. The outcomes of logistic multiple regression analysis presented that there was no significant correlation between the occurrence of ONFH and blood type A, B, AB, and O (P > 0.05). However, there are significant differences in the disease progression between the different blood types. There was a significant difference in the progression of disease between type A and type O. Among them, patients with ONFH and type A blood had the fastest progression with an average of 2.318 years, and the slowest progression was found in type O blood with an average of 5.15 years. Conclusions:The ABO blood group has no correlation with the occurrence of ONFH, but the ABO blood type is closely related to the disease progression of ONFH.

The correlation between knee osteoarthritis and the ABO blood group system in a Turkish population

“…In a more specific group of patients with femoral head avascular necrosis (AVN), Yang et al examined the relationship with ABO blood group [12]. Since it is known that there is a relationship between the ABO blood group type and venous thrombus diseases, Yang et al focussed on the relationship with AVN [13].…”

Does Diabetes Mellitus Increase the Risk of Avascular Osteonecrosis? A Systematic Review and Meta-Analysis

“…After a full-text review, 31 studies were excluded due to insufficient data, 1 due to poor quality (low NOS score) and 1 due to an overlapping cohort ( Figure 2 ). Overall, 6 studies were included [ 31 , 32 , 33 , 34 , 35 , 36 ].…”

“…Of the two large studies, the population-based study by Lai et al, designed specifically to analyze diabetes as a risk factor of AVN, reported a significantly increased risk of femoral head AVN in patients with diabetes [ 33 ]. The other large study (Yang et al 2020 [ 31 ]), carried out in a single orthopedic hospital found a non-significantly lower risk of AVN in patients with diabetes. The pooled estimate in our meta-analysis indicated an increased risk of AVN in bone sties other than the jaw among patients with diabetes, but the effect was non-significant.…”

“…In that nationwide study from Taiwan, a cohort with diabetes was compared with a cohort without diabetes matched for sex, age, corticosteroid use, and several comorbidities; the risk of avascular osteonecrosis was significantly greater in patients with diabetes (hazard ratio = 1.16; 95%CI, 1.11–1.21) [ 33 ]. The second-largest study in our systematic review was the case-control study by Yang et al [ 31 ], who compared patients with femoral head osteonecrosis ( n = 755) and those with fractures of extremities ( n = 489). These investigators reported that diabetes was associated with a non-significantly lower risk of femoral head AVN (OR = 0.81; 95%CI, 0.52–1.26).…”

Molecular genetic analysis of weak B blood group allele in Jinan population reveals distribution of ABw phenotype

“…Many ABO subgroups have been found to have a weak expression of A or B antigen on red blood cells (RBCs), which makes the detection of variant alleles one of the most important criteria for a clinically useful genotyping strategy [3] . Furthermore, the clinical significance of the ABO blood group system extends to a broader area beyond transfusion medicine and several reports have suggested an important involvement in the development of cardiovascular disease [4−5] , tumor [6] and other diseases [7] .…”