Correlation analysis of neutrophil/albumin ratio and leukocyte count/albumin ratio with ischemic stroke severity

Abstract

Background: Ischemic stroke (IS) is a common neurological disease in the elderly, but the relationship between neutrophil/albumin ratio (NAR) and leukocyte count/albumin ratio (LAR) and the severity of neurological function injury and early neurological deterioration (END)occurrence remain elusive in acute IS. Methods: A total of 299 patients with acute IS and 56 healthy controls were enrolled. According to the NIHSS score at admission, the disease group was divided into three groups (mild, moderate and severe IS), and the differences in five indexes NAR, LAR, neutrophil count, leukocyte count and albumin among the four groups were analyzed. Furthermore, explore the correlation between the above indicators and the severity of IS and END occurrence. Results: The results showed that higher NAR, LAR, neutrophil count, leukocyte count levels and lower albuminlevels were associated with acute IS, and the levels of NAR and LAR increased gradually in three groups of IS. NAR and LAR were positively and albumin was negatively correlated with the severity of IS. Meanwhile, NAR and LAR showed a good predictive value in identifying patients with END after acute IS. Conclusions: NAR and LAR may be predictors of the severity of IS and END occurrence after acute IS.

Optimizing early neurological deterioration prediction in acute ischemic stroke patients following intravenous thrombolysis: a LASSO regression model approach

“…Intravenous thrombolysis (IVT), primarily with recombinant tissue plasminogen activator (rt-PA), has emerged as the standard therapeutic approach for AIS, markedly improving patient outcomes. However, approximately 6-40% of patients undergoing IVT experience early neurological deterioration (END) (Seners et al, 2014;Mao et al, 2022), which compromises treatment efficacy and can result in heightened morbidity and mortality.…”