Correlation analysis of hypothalamic <scp>mRNA</scp> levels of appetite regulatory neuropeptides and several metabolic parameters in 28‐day‐old layer chickens

Honda, Kazuhisa; Saneyasu, Takaoki; Aoki, Koji; Shimatani, Tomohiko; Yamaguchi, Takuya; Kamisoyama, Hiroshi

doi:10.1111/asj.12320

Cited by 8 publications

(8 citation statements)

References 36 publications

(75 reference statements)

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“…For example, the mRNA levels of leptin in adipose tissue were extremely low in chickens (Seroussi et al, 2016), zebra finches (Huang et al, 2014), and rock doves (Friedman-Einat et al, 2014) and relatively low in Japanese quail (Seroussi et al, 2016). Plasma insulin levels were not correlated with either abdominal fat mass or the mRNA levels of appetite-regulating neuropeptides in the hypothalamus in layer chickens (Honda et al, 2015a). Therefore, leptin and insulin may not be primarily involved as adiposity hormones in the regulation of food intake in chickens.…”

Section: Introductionmentioning

confidence: 96%

Gut Hormones and Regulation of Food Intake in Birds

2017

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Gut hormones act as appetite regulatory hormones in mammals. For example, the hunger hormone ghrelin, which is released from the stomach before food intake, stimulates appetite. In contrast, satiety hormones such as cholecystokinin, glucagon-like peptide-1, and peptide YY, which are released from the intestines after food intake, suppress appetite. The effects of these peptides on food intake have been shown to be similar in both mammals and fishes. However, evidence suggests that the physiological roles of these gut hormones may be different between birds and other vertebrates. This review summarizes the current information on the roles of gut hormones in the regulation of food intake in birds, especially in chickens.

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Section: Introductionmentioning

confidence: 96%

Gut Hormones and Regulation of Food Intake in Birds

2017

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“…Similar results were found when Saneyasuand coworkers (Saneyasu et al, 2013) investigated one of the most potent orexigenic peptide encoding gene expression, namely neuropeptide Y (NPY), and found that mRNA levels of these genes are age-dependently decreased in the broiler chicken hypothalamus. NPY expression was also found to be decreasing in layer type chickens with age (Honda et al, 2015) and pro-opiomelanocortin which encodes anorexigenic peptides was found to be increased with age. An age-dependent increase in cocaine-amphetamine regulated transcript (an anorexigenic peptide) level was found in the chicken hypothalamus (Cai et al, 2015).…”

Section: Discussionmentioning

confidence: 94%

Feeding state and age dependent changes in melanin-concentrating hormone expression in the hypothalamus of broiler chickens

Simon¹,

Németh²,

Jávor³

et al. 2018

Acta Biochim Pol

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We aimed to quantify the gene expression changes of the potent orexigenic melanin concentrating hormone (MCH) in chicken (Gallus gallus) hypothalamus with quantitative real-time polymerase chain reaction (qPCR), and for the first time determine peptide concentrations with a novel radioimmunoassay (RIA) under different feeding status. Three different experimental conditions, namely ad libitum fed, fasting for 24h, fasting for 24h then refed for 2h were applied to study the changes of the aforementioned target and its receptor (MCHR4) gene expression to different nutritional states. The relative changes of MCH and MCHR4 were also studied from 7 to 35 days of age. Expression of PMCH and MCHR4 along the gastrointestinal tract (GIT) was also investigated. We found that both targets expression are restricted to the hypothalamus, only weak expression was detected along the GIT. Different nutritional states did not affect the PMCH and MCHR4 mRNA levels. However, fasting for 24h significantly increased MCH-like immunoreactivity with 25.65%. Fasting for 24h then refed for 2h further significantly increased MCH peptide concentration by 32.51% compared to ad libitum state. Decreasing trend with age was observable both for PMCH and MCHR4 mRNA levels and also for MCH-like immunoreactivity. Correlation analysis did not result significant correlation between MCH peptide concentration and abdominal fat mass in ad libitum fed birds. In conclusion, MCH peptide concentration altered with different feeding states, which indicated that this peptide takes part in feed intake regulation (short-term signalization of feed intake) of broiler chickens in a same manner as in mammals.

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“…Plasma insulin concentration in broiler chicks (Cobb) is known to increase with age [31,32]. Interestingly, hypothalamic POMC expression decreases with age in broiler chickens (Chunky) [33], but increases in layer chickens (White Leghorn) [34]. These findings suggest that hypothalamic insulin resistance develops with increasing age in broiler chickens.…”

Section: Resultsmentioning

confidence: 99%

Central administration of insulin and refeeding lead to the phosphorylation of AKT, but not FOXO1, in the hypothalamus of broiler chicks

Saneyasu

Fukuzo

Kitashiro

et al. 2019

Physiology & Behavior

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Several studies in rodents and layer chickens have demonstrated that insulin upregulates hypothalamic AKT-mediated signaling and expression of proopiomelanocortin (POMC, the precursor of alpha-melanocyte stimulating hormone, an anorexigenic peptide) and suppresses appetite in these animals. However, a previous study has also reported that insulin fails to suppress food intake in broiler chicks. In the present study, no significant differences were observed in hypothalamic AKT and forkhead box O1 (FOXO1) phosphorylation levels between broiler and layer chicks. The phosphorylation rate of AKT, but not that of FOXO1, increased in the hypothalami of broilers refed for 1 h after a 24-h fast, with a corresponding increase in plasma insulin concentration. Intracerebroventricular (ICV) administration of 50 pmol insulin, which could decrease food intake in broiler chicks, significantly increased the AKT phosphorylation rate, whereas no significant change was observed in FOXO1 phosphorylation or POMC expression after ICV insulin administration. These findings suggest that hypothalamic AKT responds to insulin in broiler chicks, but FOXO1-mediated regulation of POMC expression is not induced by insulin, which may be one of the causes of excessive food intake in broiler chickens.

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Correlation analysis of hypothalamic mRNA levels of appetite regulatory neuropeptides and several metabolic parameters in 28‐day‐old layer chickens

Cited by 8 publications

References 36 publications

Gut Hormones and Regulation of Food Intake in Birds

Gut Hormones and Regulation of Food Intake in Birds

Feeding state and age dependent changes in melanin-concentrating hormone expression in the hypothalamus of broiler chickens

Central administration of insulin and refeeding lead to the phosphorylation of AKT, but not FOXO1, in the hypothalamus of broiler chicks

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