Correlation analysis of candidate gene SNP for high-yield in Liaoning cashmere goats with litter size and cashmere performance

Chang, Yue; Bai, Wen; Hui, Tai Y.; Sun, Jia; Guo, Dan; Guo, Su L.; Wang, Ze Y

doi:10.1080/10495398.2019.1652188

Cited by 18 publications

(16 citation statements)

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“…Bengal goat (p= <0.05). Significant effect of genotypes on litter size have been reported in Liaoning cashmere goats and Markhoz goat (Ghoreishi et al 2019;Yue et al 2019). In contrast, Ahlawat et al (2015) and Ahlawat et al (2016) reported a non-significant effect of genotypes on litter size in Indian Black Bengal goat.…”

Section: Discussionmentioning

confidence: 93%

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Polymorphism of fecundity genes (BMP15andGDF9) and their association with litter size in Bangladeshi prolific Black Bengal goat

Das

Shaha

Gupta

et al. 2020

Preprint

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18The primary objective of this study was to identify polymorphisms in two major fecundity genes 19 (BMP15 and GDF9) and their association with litter size in Black Bengal goat, a prolific goat breed 20 in Bangladesh. Total 40 blood samples were collected from Black Bengal does with twining 21 records in the first three parities. All sampled animals were genotyped for fragments of exon 2 of 25 g.1173_1174insA) in GDF9 gene. Association analysis for polymorphic loci showed litter size in 26 Black Bengal goat significantly varied between genotypes at g.735G>A and g.781C>A loci of 27 BMP15 gene. Further studies with a high number of genetically unrelated animals for assessing the 28 association of these loci and others in the fecundity genes with litter size may be useful. 29

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Section: Discussionmentioning

confidence: 93%

“…gene (Ahlawat et al 2015;Shokrollahi and Morammazi 2018;Yue et al 2019). Polley et al (2009) who screened Black Bengal goats of India for the presence of mutations in BMP15 and GDF9 genes already associated with prolificacy in sheep and reported the wild 7 type genotype only.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of fecundity genes (BMP15andGDF9) and their association with litter size in Bangladeshi prolific Black Bengal goat

Das

Shaha

Gupta

et al. 2020

Preprint

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“…Immunological traits g.G443A [67] TAP1 PRRSV resistance c.933A > G [68] TLR3 PRRSV susceptibility c.761A > G [69] IRF7 Health and immunity g.2115T > C [70] LMP2 Haematological traits g.1232C > G [70] LMP7 Haematological traits c.C522T [71] BPI Disease resistance c.A1060G [71] BPI Disease resistance c.C1027A [72] TLR4 Salmonella shedding c.8C > G [73] PSMB6 Immunological traits c.144T > C [74] BCL10 Immunological traits [75][76][77] . Although CRISPR/Cas9 is used extensively to make precise insertions, deletions or any point mutation of interest, a number of limitations are attributed to HDR editing.…”

Section: Snps Responsible For Disease Resistancementioning

confidence: 99%

Base editing in pigs for precision breeding

Song¹,

Wang²,

Zhao³

2020

Front. Agr. Sci. Eng.

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Pigs are one of the most important domesticated animals and have great value in agriculture and biomedicine. Single nucleotide polymorphisms (SNPs) are a dominant type of genetic variation among individual pigs and contribute to the formation of traits. Precision single base substitution provides a strategy for accurate genetic improvement in pig production with the characterization of functional SNPs and genetic variants in pigs. Base editing has recently been developed as the latest gene-editing tool that can directly make changes in single nucleotides without introducing double-stranded DNA breaks (DSBs), providing a promising solution for precise genetic modification in large animals. This review summarizes gene-editing developments and highlights recent genetic dissection related to SNPs in major economic traits which may have the potential to be modified using SNP-editing applications. In addition, limitations and future directions of base editing in pig breeding are discussed.

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“…By contrast, FecB has additive effect with homozygote females having a higher lambing rate than their heterozygous counterparts [23] . A mutation in the 3′UTR of the FecB gene has similarly been associated with increased prolificacy in goats [24] . Improved lambing rate is desirable in some husbandry systems, and a CRISPR/Cas-induced point mutation has been used to introduce the Q249R mutation into the FecB of Chinese Tan sheep [14] .…”

Section: Production Traitsmentioning

confidence: 99%

Livestock breeding for the 21st century: the promise of the editing revolution

Proudfoot¹,

McFarlane²,

Whitelaw³

et al. 2020

Front. Agr. Sci. Eng.

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In recent years there has been a veritable explosion in the use of genome editors to create sitespecific changes, both in vitro and in vivo, to the genomes of a multitude of species for both basic research and biotechnology. Livestock, which form a vital component of most societies, are no exception. While selective breeding has been hugely successful at enhancing some production traits, the rate of progress is often slow and is limited to variants that exist within the breeding population. Genome editing provides the potential to move traits between breeds, in a single generation, with no impact on existing productivity or to develop de novo phenotypes that tackle intractable issues such as disease. As such, genome editors provide huge potential for ongoing livestock development programs in light of increased demand and disease challenge. This review will highlight some of the more notable agricultural applications of this technology in livestock.

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Correlation analysis of candidate gene SNP for high-yield in Liaoning cashmere goats with litter size and cashmere performance

Cited by 18 publications

References 50 publications

Polymorphism of fecundity genes (BMP15andGDF9) and their association with litter size in Bangladeshi prolific Black Bengal goat

Polymorphism of fecundity genes (BMP15andGDF9) and their association with litter size in Bangladeshi prolific Black Bengal goat

Base editing in pigs for precision breeding

Livestock breeding for the 21st century: the promise of the editing revolution

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