Polymorphism of fecundity genes (<i>BMP15</i>and<i>GDF9</i>) and their association with litter size in Bangladeshi prolific Black Bengal goat

Das, Ashutosh; Shaha, Mishuk; Gupta, Mukta Das; Dutta, Avijit; Miazi, Omar Faruk

doi:10.1101/2020.01.08.899443

“…According to Ahlawat et al, 3 the impact of parity on litter size in Indian Black Bengal goats is significant (P<0.01). Das et al 37 also noticed a highly significant (P<0.001) influence of parity on litter size in this investigation. Ahlawat et al 5 investigated the relationship with new SNPs in the BMP15, BMPR1B and GDF9 genes and litter size in seven Indian goat breeds.…”

Section: Polymorphisms and Frequency Distributions Of The Bmpr1b Genesupporting

confidence: 74%

“…The Kosta goat had only homozygous AA, the Samosir goat had two genotypes AA (0.88) and AG (0.12), and three genotypes were found in Gembrong as the following AA (0.40), GG (0.20), and AG (0.40). Meanwhile, in the Kacang goat two genotypes were detected in the study 24 AA and AG were 0.58 for A allele and G allele was 0.42, in contrary Das et al 25 reported that allele G had higher frequency than allele A as the following 0.762 and 0.238 respectively. PCR-RFLP analysis in SNP (g. 135G>C) 17 showed only the GG genotype.…”

Section: Polymorphisms and Frequency Distributions Of The Bmp15 Genementioning

confidence: 68%

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

Abuzahra

¹

,

Eid

²

,

Effendi

³

et al. 2023

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Background: Litter size (LS) is a significant, challenging, and economical aspect of the goat industry in Indonesia. It is influenced by several different factors and genes; consequently, identifying potential genes and loci associated with litter size has become a genetic problem. Several genetic indicators have been found to be associated with litter size in goats. This has prompted the need to discuss candidate genes associated with litter size in goats in Indonesia. Methods: A systematic review was conducted using critical databases including ResearchGate, Google Scholar, PubMed, Google search engine and Science direct. There were any exclusion criteria, they were as follows: articles published in languages other than English, Conference papers, short communication papers and papers not related to animals. After reviewing the abstracts of 42 publications, the remaining 17 investigations were chosen for full paper evaluation. A further eight studies were removed after a comprehensive evaluation of the publications because they did not match our inclusion criteria. Results: These markers include growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), bone morphogenetic protein receptor type IB (BMPR1B), and kisspeptin (KISS1). Single nucleotide polymorphisms in these genes contribute to the development of novel genetic markers that helps in the selection of goats with the most favorable genotypes for litter size. This type of genetic selection is more successful than the traditional way of selecting animals for reproductive traits, particularly litter size. Conclusions: As a result, this study summarizes the genetic impacts of polymorphisms in candidate genes associated with litter size features in Indonesian goats.

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“…In agreement with our observation, other studies also reported no association of this SNP with litter size in goats (Hadizadeh et al 2014;Ahlawat et al 2015b;Ahlawat et al 2016;Shokrollahi and Morammazi, 2018). In our previous research (Das et al 2021), the effect of different genotypes at the G735A locus in the BMP15 gene on the litter size in the Black Bengal goats of Bangladesh was significant. Though not statically significant, Jamunapari goats with AA genotype in the present study had a smaller litter size than GG and GA genotypes at the G735A locus of the BMP15 gene.…”

Section: Discussionsupporting

confidence: 92%

“…In a recent study, the Bangladeshi Black Bengal goat was reported carried five SNPs within 686 to 813 bp of the exon 2 of BMP15 (Das et al 2021). Jamunapari and crossbred goat in the present study showed two SNPs (G735A and G811A) within the same region of the BMP15 gene.…”

Section: Discussionsupporting

confidence: 54%

“…Studies on the detection of genetic polymorphisms for litter size in Bangladeshi goat is scanty. In our previous study (Das et al 2021), we detected litter size associated polymorphic loci in the Black Bengal goat of Bangladesh, which led us to screen genetic markers in litter size associated genes in Bangladeshi Jamunapari and crossbred goats. In this study, two major fecundity genes viz.…”

Section: Introductionmentioning

confidence: 99%

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Identification of polymorphisms in GDF9 and BMP15 genes in Jamunapari and crossbred goats in Bangladesh

Shaha

¹

,

Miah²,

Lima³

et al. 2022

Trop Anim Health Prod

1

0

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Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are two crucial fecundity genes associated with litter size traits in the goat. Our previous study on GDF9 and BMP15 genes detected single nucleotide polymorphisms (SNPs) associated with litter size in Bangladeshi Black Bengal goats. In this study, Jamunapari and crossbred goats of Bangladesh were screened to identify polymorphisms in the GDF9 and BMP15 genes and to assess the association between identified SNPs and litter size. The genomic DNA from 100 goats (50 Jamunapari and 50 crossbred) was used in Polymerase Chain Reaction (PCR) to amplify the exon 2 of the GDF9 and exon 2 of the BMP15 gene. PCR products were sequenced employing the BigDye Terminator cycle sequencing protocol, to identify SNPs. A generalized linear model was utilized to perform the association analysis for identified SNPs and litter size. Seven SNPs were identified, of which four: C818CT, G1073A, G1189A and G1330T were in the GDF9 gene, three: G616T, G735A and G811A were in the BMP15 gene. G735A was a synonymous SNP, whereas the remaining were non-synonymous SNPs. Identified SNP loci in GDF9 were low polymorphic (PIC<0.25) while loci in BMP15 were moderately polymorphic (PIC≥0.25). The genotypes at the G1330T locus had a significant (p<0.05) difference in litter size in Jamunapari goat, but no significant difference was observed for all genotypes at other loci. This study provides additional molecular markers that would be useful for future research on the litter size trait in goats of Bangladesh.

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Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

Abuzahra,

Abu Eid,

Effendi

et al. 2023

F1000Res

1

0

View full text Add to dashboard Cite

Background: Litter size (LS) is a significant, challenging, and economical aspect of the goat industry in Indonesia. It is influenced by several different factors and genes; consequently, identifying potential genes and loci associated with litter size has become a genetic problem. Several genetic indicators have been found to be associated with litter size in goats. This has prompted the need to discuss candidate genes associated with litter size in goats in Indonesia. Methods: A systematic review was conducted using critical databases including ResearchGate, Google Scholar, PubMed, Google search engine and Science direct. There were any exclusion criteria, they were as follows: articles published in languages other than English, Conference papers, short communication papers and papers not related to animals. After reviewing the abstracts of 42 publications, the remaining 17 investigations were chosen for full paper evaluation. A further eight studies were removed after a comprehensive evaluation of the publications because they did not match our inclusion criteria. Results: These markers include growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), bone morphogenetic protein receptor type IB (BMPR1B), and kisspeptin (KISS1). Single nucleotide polymorphisms in these genes contribute to the development of novel genetic markers that helps in the selection of goats with the most favorable genotypes for litter size. This type of genetic selection is more successful than the traditional way of selecting animals for reproductive traits, particularly litter size. Conclusions: As a result, this study summarizes the genetic impacts of polymorphisms in candidate genes associated with litter size features in Indonesian goats.

show abstract

Polymorphism of fecundity genes (BMP15andGDF9) and their association with litter size in Bangladeshi prolific Black Bengal goat

Cited by 4 publications

References 30 publications

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

Identification of polymorphisms in GDF9 and BMP15 genes in Jamunapari and crossbred goats in Bangladesh

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

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