We report an experimental investigation of four interband cascade lasers with wavelengths spanning the mid-infrared spectral range, i.e., 2.9 lm to 5.2 lm, near room temperature in pulsed mode. One broad-area device had a pulsed threshold current density of only 3.8 A/cm 2 at 78 K (k = 3.6 lm) and 590 A/cm 2 at 300 K (k = 4.1 lm). The room-temperature threshold for the shortest-wavelength device (k = 2.6 lm to 2.9 lm) was even lower, 450 A/cm 2 . A cavity-length study of the lasers emitting at 3.6 lm to 4.1 lm yielded an internal loss varying from 7.8 cm -1 at 78 K to 24 cm -1 at 300 K, accompanied by a decrease of the internal efficiency from 77% to 45%.