Objectives: This article examines whether sexual minority men and women experience greater increases in depressive symptoms and loneliness with age compared to heterosexual men and women. Methods: Using three waves of data from sexual minority (n Men = 87 and n Women = 62) and heterosexual (n Men = 1,297 and n Women = 1,362) older adults in the National Social Life, Health, and Aging Project, we used latent growth curve modeling to test whether change in depressive symptoms and loneliness varies across sexual orientation and whether annual household income and family support accounted for this change. Results: Although differences in the growth trajectories of depressive symptoms and loneliness across sexual orientation were not observed, gender differences were. Annual household income and family support more strongly influenced initial depressive symptoms and loneliness in sexual minority men and women than in heterosexual men and women. Conclusions: Trajectories of depressive symptoms and loneliness in older adulthood do not vary by sexual orientation. Economic and family resources may allow sexual minorities to cope effectively with depressive symptoms and loneliness. Depressive symptoms and loneliness are highly correlated constructs that have not been studied in sexual minority status groups. Older adult members of sexual minorities are at greater risk for depressive symptomatology (Fredriksen-Goldsen, Kim, Barkan, Muraco, & Hoy-Ellis, 2013) and loneliness (Jacobs & Kane, 2012; Kim & Fredriksen-Goldsen, 2016). Increased risk of each is notable given that suicide risk, a potential consequence of depression and loneliness (Agerbo, Stack, & Petersen, 2011; Kalmar et al., 2008; Stickley & Koyanagi, 2016), is significantly higher among sexual minority adults compared to heterosexual adults (Björkenstam, Andersson, Dalman, Cochran, & Kosidou, 2016). The majority of sexual minority studies on depressive symptoms and loneliness are crosssectional, which does not address whether longitudinal trajectories vary by sexual orientation. The purpose of the current study, thus, is to compare change in depressive symptoms and loneliness between older adult sexual minority men and women and their heterosexual counterparts.