The paper estimates a health production function for Asian developing countries based on the Grossman (1972) theoretical model that treats social, economic, and environmental factors as inputs of the production system. In estimating this function, socioeconomic and environmental factors such as income per capita, literacy rate, food availability, health expenditure, health services, urbanization rate, population, and carbon dioxide emission are specified as determinants of health status. The parameters of the function are estimated by one-way and two-way fixed and random effects model of panel data analyses. The results of the one-way fixed effect model suggest that an increase in GDP per capita, food availability and literacy rate, and decrease in carbon dioxide emissions are strongly associated with an improvement in life expectancy at birth. Overall, the results imply that a health policy may focus on the provision of health services and environmental aspects may do little to improve the current health status of the region.