Correlates of cervical mucosal antibodies to human papillomavirus 16: Results from a case control study

Bierl, Cynthia; Karem, Kevin L.; Poon, Alysia C.; Swan, David C.; Tortolero‐Luna, Guillermo; Follen, Michele; Wideroff, Louise; Unger, Elizabeth R.; Reeves, William C.

doi:10.1016/j.ygyno.2005.07.100

Cited by 23 publications

(21 citation statements)

References 17 publications

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“…Goncalves et al [18] demonstrated that patients characterized by low levels of total secreted IgA were significantly more susceptible to HPV colonization in their oral and genital mucosa. Nguyen et al [16] and Bierl et al [17] also reported a correlation between low IgA levels and an increased susceptibility to HPV infection.…”

Section: Discussionmentioning

confidence: 93%

Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women

Guimarães

Brandão

et al. 2008

Human Immunology

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Section: Discussionmentioning

confidence: 93%

Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women

Guimarães

Brandão

et al. 2008

Human Immunology

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“…Using a rat model, Avila demonstrated that repeated exposure to cocaine followed by withdrawal led to activation of the neuroendocrine stress response, which alters cellular immunity and possibly contributes to an increased susceptibility to infection [13]. HPV in humans is felt to be controlled, at least in part, by an intact mucosal immune system [32]. Perhaps most germane to our findings is the work of Lopez [33] and colleagues, who found that daily cocaine administration induced a significant decrease in the number of IgA+ cells with a concomitant increase in the number of CD8+ cells per villi in the intestinal lamina propria (ILP).…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Cocaine Use and Human Papillomavirus Infections in HIV-Seropositive and HIV-Seronegative Women

Minkoff

Strickler

et al. 2008

Infectious Diseases in Obstetrics and Gynecology

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Objective. Animal data suggest that cocaine has an immunosuppressive effect, but no human studies have been conducted to assess the relation of cocaine use with human papillomavirus (HPV) infection, the viral cause of cervical cancer. Since both cocaine use and HPV infection are common among HIV-positive women, we sought to determine whether use of cocaine and/or crack influences the natural history of HPV among women with or at high risk of HIV. Methods. Women enrolled in the Women's Interagency HIV Study (2278 HIV-seropositive and 826 high-risk seronegative women) were examined every six months for up to 9.5 years with Pap smear, collection of cervicovaginal lavage (CVL) samples, and detailed questionnaires regarding health and behavior, including use of crack and cocaine (crack/cocaine). CVLs were tested for HPV DNA by PCR, with genotyping for over forty HPV types. Results. In multivariate logistic regression models, censoring women treated for cervical neoplasia, crack/cocaine use within the last six months was associated with prevalent detection of oncogenic HPV DNA (odds ratio [OR] = 1.30 (1.09–1.55)), and with oncogenic HPV-positive squamous intraepithelial lesions (SIL) (OR = 1.70 (1.27–2.27)), following adjustment for age, race, HIV-serostatus, and CD4+ T-cell count, the number of sexual partners in the past six months, and smoking. In multivariate Cox models crack/cocaine use was also associated with a trend that approached significance in regard to incident detection of oncogenic HPV-positive SIL (HR = 1.51, 95% CI 0.99–2.30), and while the rate of oncogenic HPV clearance was not related to cocaine use, the clearance of any SIL was significantly lower in those with versus those without recent crack/cocaine use (HR = 0.57, 95% CI 0.34–0.97). Conclusions. Cocaine use is associated with an increased risk of detection of both prevalent and incident oncogenic HPV infection, as well as an increased risk of HPV-positive SIL over time.

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“…Nevertheless, MBL2 genetic variants were associated previously with susceptibility to HPV infection in Brazilian [Guimaraes et al, ], Taiwan [Tsai et al, ] and Italian subjects [Segat et al, ] but not in a southern Brazilian [Ramos et al, ] and in a center‐southern Italian populations [Parrella et al, ]. HPV is a non‐enveloped virus, and actually it is not known if MBL could interact directly with the virus; nevertheless MBL can bind to IgA and then activate the lectin pathway of complement system [Roos et al, ], and some works observed an association between low IgA levels and increased susceptibility towards HPV infection [Bierl et al, ; Nguyen et al, ; Gonçalves et al, ].…”

Section: Discussionmentioning

confidence: 99%

MBL2polymorphisms in women with atypical squamous cells of undetermined significance

et al. 2015

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Infection with high risk Human papillomavirus (HPV) is the main known cause of cervical cancer. HPV induces different grades of lesions: among them, Atypical squamous cells of undetermined significance are abnormal lesions that could evolve in pre-cancer lesions or spontaneously regress. The mannose binding lectin (MBL) is an innate immunity serum protein also found in cervico-vaginal mucosa, whose expression is known to be affected by polymorphisms in exon 1 and promoter of the MBL2 gene. In the present study the possible association between MBL2 functional polymorphisms and susceptibility to develop atypical squamous cells of undetermined significance was investigated in a group of women from North-East of Italy, stratified for HPV infection status. The MBL2 D and O alleles and the deficient producer combined genotypes, responsible for low MBL production, were more represented among atypical squamous cells of undetermined significance positive women than healthy controls and the results were confirmed when only HPV negative samples were considered. These results suggest a possible involvement of MBL2 functional polymorphisms in atypical squamous cells of undetermined significance susceptibility.

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Correlates of cervical mucosal antibodies to human papillomavirus 16: Results from a case control study

Cited by 23 publications

References 17 publications

Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women

Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women

The Relationship between Cocaine Use and Human Papillomavirus Infections in HIV-Seropositive and HIV-Seronegative Women

MBL2polymorphisms in women with atypical squamous cells of undetermined significance

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