The study included determining the extent of the effect of common vaccines for the COVID-19 on the liver functions of people who were not previously infected with the virus. Whether vaccinated or not with Corona virus (COVID-19) vaccines, and of both sexes regardless, their total number was 280 people. 70 samples of Pfizer vaccine, 70 Sinopharm, and 70 AstraZeneca. In addition to 70 samples for the control group for ages between (18-70) years. During the period from October 2021 to the end of April 2022, The highest value of liver function readings (GOT, GPT) was recorded. Those vaccinated with Pfizer were (24.4 and 25.1). However, respectively, the lowest value was recorded for those vaccinated with Sinopharm, which was (22.9 and 23.9). Whilst the highest value for liver function readings (TSB and ALP) was recorded for those vaccinated with AstraZeneca which was (0.8 and 169.1). By comparing the results to the control group between the vaccinated and the non-vaccinated, as well as between the type of vaccine, there were no significant differences and high statistically significant effects that prevented the use of these vaccines against the Corona virus (COVID-19), which are safe and have no side effects on liver functions.