Correction to "Synthesis of sparse planar arrays using modified real genetic algorithm"

Ke-song, Chen; Yun, Xiaohua; He, Zishu; Han, Chuang

doi:10.1109/tap.2007.898240

Cited by 2 publications

(1 citation statement)

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“…Soft corals of the Sinularia genus are a rich source of terpenoids, steroids, and others. 1 We have previously discovered a series of sesquiterpenoids, [2][3][4] norcembranoids, 5 cembranoids, 6 steroids, [7][8][9] and other metabolites 10 from Formosan soft corals of this genus. Our recent investigation of bioactive natural products from two Formosan soft corals, Sinularia querciformis (Pratt, 1903, family Alcyoniidae) and S. granosa (Tixier-Durivault, 1970, family Alcyoniidae), has led to the isolation of six new cembranoids (1)(2)(3)(4)(5)(6), along with two known metabolites, 7 and 8.…”

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Anti-inflammatory Cembranoids from the Soft Corals Sinularia querciformis and Sinularia granosa

Huang

Lin

et al. 2008

J. Nat. Prod.

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Four new cembranoids, querciformolides A-D (1-4), along with two known cembranoids, 7 and 8, have been isolated from the soft coral Sinularia querciformis. Furthermore, chemical investigation of Sinularia granosa has afforded three new cembranoids, querciformolide B (2) and granosolides A (5) and B (6). The structures of the new metabolites were elucidated on the basis of extensive spectroscopic methods, and that of 2 was further confirmed by X-ray diffraction analysis. The absolute configurations of 1 and 2 were determined by a modified Mosher's method. Among these metabolites, 2-6 are rarely found cembranoids possessing a tetrahydrofuran moiety with a 4,7-ether linkage; in addition, 1 is the first epsilon-lactone cembrane found that possesses a tetrahydropyran moiety with a 4,8-ether linkage. None of these compounds were found to be cytotoxic toward a limited panel of cancer cell lines. However, compounds 3, 7, and 8 significantly inhibited the accumulation of the pro-inflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells.

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