Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings

Pelletier, Jonathan; Kumar, Karan; Engen, Rachel M.; Bensimhon, Adam; Varner, Jennifer D.; Rheault, Michelle N.; Srivastava, Tarak; Straatmann, Caroline; Silva, Cynthia; Davis, Thomas K.; Wenderfer, Scott E.; Gibson, Keisha; Selewski, David T.; Barcia, John; Weng, Patricia L.; Licht, Christoph; Jawa, Natasha; Kallash, Mahmoud; Foreman, John W.; Wigfall, Delbert R.; Chua, Annabelle N.; Chambers, Eileen Tsai; Hornik, Christoph P.; Brewer, Eileen D.; Nagaraj, Shashi; Greenbaum, Larry A.; Gbadegesin, Rasheed

doi:10.1007/s00467-018-4103-3

Cited by 3 publications

(10 citation statements)

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“…Our observation is in line with previous studies that report no or very low relapse rate after transplantation in children with genetic SRNS [9,17,19]. Few old reports have suggested a risk of relapse for genetic SRNS, but they are almost all related to NPHS2 mutation, including heterozygous individuals [20][21][22][23].…”

Section: Discussionsupporting

confidence: 92%

“…Nehus et al reported a higher rate of recurrence in younger children, among a cohort of 327 patients, though genetic results were not reported for any participants [24]. No significant difference in relapse rate according to the age at transplant were detected by Tejani and Stablein [12] and in the more recent studies by Ding et al and Pelletier et al [17,19]. Again, unavailability of genetic testing for the majority of their patients could justify the different findings.…”

Section: Discussionmentioning

confidence: 95%

“…Kashgary et al in their meta-analysis identified a remission rate of 70.2% in children treated with PE [14]. A lower response rate was reported by Pelletier [19], but remission information was available only for 49/64 (77%) relapsed patients and the detailed immunosuppressive strategy is missing. According to our results, PE is confirmed as an effective treatment for recurrence.…”

Section: Discussionmentioning

confidence: 98%

“…The result is slightly superior than previously reported. When genetic patients are excluded, Ding [17] and Pelletier [19] found a relapse rate of 46.3% and 47%, respectively. The lower recurrence rate described by these groups could be justified by the presence of unknown genetic SRNS patients.…”

Section: Discussionmentioning

confidence: 98%

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Post-transplant recurrence of steroid resistant nephrotic syndrome in children: the Italian experience

et al. 2019

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Background Steroid resistant nephrotic syndrome (SRNS) is a frequent cause of end stage renal disease in children and post-transplant disease recurrence is a major cause of graft loss. Methods We identified all children with SRNS who underwent renal transplantation in Italy, between 2005 and 2017. Data were retrospectively collected for the presence of a causative gene mutation, sex, histology, duration of pre-transplant dialysis, age at onset and transplant, HLA matching, recurrence, therapy for recurrence, and graft survival. Results 101 patients underwent a first and 22 a second renal transplant. After a median follow-up of 58.5 months, the disease recurred on the first renal transplant in 53.3% of patients with a non-genetic and none with a genetic SRNS. Age at transplant > 9 years and the presence of at least one HLA-AB match were independent risk factors for recurrence. Duration of dialysis was longer in children with relapse, but did not reach statistical significance. Overall, 24% of patients lost the first graft, with recurrence representing the commonest cause. Among 22 patients who underwent a second transplant, 5 suffered of SRNS recurrence. SRNS relapsed in 5/9 (55%) patients with disease recurrence in their first transplant and 2 of them lost the second graft. Conclusions Absence of a causative mutation represents the major risk factor for post-transplant recurrence in children with SRNS, while transplant can be curative in genetic SRNS. A prolonged time spent on dialysis before transplantation has no protective effect on the risk of relapse and should not be encouraged. Retransplantation represents a second chance after graft loss for recurrence.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

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Post-transplant recurrence of steroid resistant nephrotic syndrome in children: the Italian experience

et al. 2019

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“… 10 Moreover, initial steroid sensitivity has been associated with a higher rate of PTx-REC compared with primary steroid-resistant patients. 11 , 12 …”

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confidence: 99%

A Systematic Review and Meta-Analysis of the Rate and Risk Factors for Post-transplant Disease Recurrence in Children With Steroid Resistant Nephrotic Syndrome

Morello

Proverbio²,

Puccio³

et al. 2023

Kidney International Reports

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Challenges in primary focal segmental glomerulosclerosis diagnosis: from the diagnostic algorithm to novel biomarkers

Jacobs-Cachá

Vergara

García-Carro

et al. 2020

Clinical Kidney Journal

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Primary or idiopathic focal segmental glomerulosclerosis (FSGS) is a kidney entity that involves the podocytes, leading to heavy proteinuria and in many cases progresses to end-stage renal disease. Idiopathic FSGS has a bad prognosis, as it involves young individuals who, in a considerably high proportion (∼15%), are resistant to corticosteroids and other immunosuppressive treatments as well. Moreover, the disease recurs in 30–50% of patients after kidney transplantation, leading to graft function impairment. It is suspected that this relapsing disease is caused by a circulating factor(s) that would permeabilize the glomerular filtration barrier. However, the exact pathologic mechanism is an unsettled issue. Besides its poor outcome, a major concern of primary FSGS is the complexity to confirm the diagnosis, as it can be confused with other variants or secondary forms of FSGS and also with other glomerular diseases, such as minimal change disease. New efforts to optimize the diagnostic approach are arising to improve knowledge in well-defined primary FSGS cohorts of patients. Follow-up of properly classified primary FSGS patients will allow risk stratification for predicting the response to different treatments. In this review we will focus on the diagnostic algorithm used in idiopathic FSGS both in native kidneys and in disease recurrence after kidney transplantation. We will emphasize those potential confusing factors as well as their detection and prevention. In addition, we will also provide an overview of ongoing studies that recruit large cohorts of glomerulopathy patients (Nephrotic Syndrome Study Network and Cure Glomerulonephropathy, among others) and the experimental studies performed to find novel reliable biomarkers to detect primary FSGS.

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Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings

Abstract: The original version of this article unfortunately contained a mistake. The subtitle BA Midwest Pediatric Nephrology Consortium (MWPNC) study^was missing. The correct title including subtitle is given above.

Cited by 3 publications

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Post-transplant recurrence of steroid resistant nephrotic syndrome in children: the Italian experience

Post-transplant recurrence of steroid resistant nephrotic syndrome in children: the Italian experience

A Systematic Review and Meta-Analysis of the Rate and Risk Factors for Post-transplant Disease Recurrence in Children With Steroid Resistant Nephrotic Syndrome

Challenges in primary focal segmental glomerulosclerosis diagnosis: from the diagnostic algorithm to novel biomarkers

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