A Systematic Review and Meta-Analysis of the Rate and Risk Factors for Post-transplant Disease Recurrence in Children With Steroid Resistant Nephrotic Syndrome

Morello, William; Proverbio, Emanuele; Puccio, Giuseppe; Montini, Giovanni

doi:10.1016/j.ekir.2022.10.030

Cited by 6 publications

(2 citation statements)

References 29 publications

(68 reference statements)

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“…The entire process is shown in Figure 1. After retrieving eligible studies, three reviewers (AAM, GVR, and AC) independently critically appraised the studies' methodology and categorized the risk of bias for each study according to the Joanna Briggs Institute (JBI) critical appraisal tools, as follows: ≤49% ("high"), 50-69% ("moderate"), and >70% ("low") [33][34][35][36]. The studies' risk of bias assessment results and the Joanna Briggs Institute (JBI) critical appraisal tools' checklists are provided in Appendices (Tables 5-8).…”

Section: Studies Selection and Data Extractionmentioning

confidence: 99%

Cranberry Supplements for Urinary Tract Infection Prophylaxis in Pregnant Women: A Systematic Review of Clinical Trials and Observational Studies on Efficacy, Acceptability, Outcomes Measurement Methods, and Studies’ Feasibility

Bolgarina,

Merriam,

Gonzalez-Gonzalez

et al. 2023

Cureus

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Cranberry supplements are commonly used to prevent urinary tract infections (UTIs). However, their usefulness is uncertain in pregnant women. We aimed to comprehensively summarize the current knowledge on cranberry supplements' efficacy and acceptability during pregnancy in addition to the outcomes measurement methods and studies' feasibility. To achieve it, we searched PubMed, PMC, and Europe PMC databases plus screened citations followed by critical appraisal of included eligible Englishwritten primary studies that (1) focused on pregnant women supplemented with any cranberry supplements;(2) provided data on cranberry supplements' efficacy, acceptability, outcomes measurement methods, and studies' feasibility; (3) included human subjects; and (4) published worldwide. Two randomized clinical trials (RCTs) and one nested cohort study, including 1156 pregnant women in total, contributed to our analysis. A tendency toward UTI reduction was demonstrated, although the results' validity was impacted by significant juice-induced gastrointestinal intolerance (23%; 44 of 188 subjects). Changing the form of supplementation from cranberry juice to capsules reduced the issue, causing side effects in one of 49 subjects (2%). Nevertheless, both RCTs still experienced significant recruitment and retention problems, which were at 33% and 59% on average, respectively. Newly acquired safety data on 919 more subjects suggests no increased risks of all malformations, vaginal bleeding, and neonatal complications. Investigating cranberry capsules' efficacy as a non-antibacterial option for UTI prevention in pregnant women has become a feasible and important direction with the current advancement in understanding cranberry supplements' actions, recommended doses plus regimens, and their safety in the population. We reviewed the challenges and discovered knowledge gaps and the implementation strategies for future studies.

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Section: Studies Selection and Data Extractionmentioning

confidence: 99%

Cranberry Supplements for Urinary Tract Infection Prophylaxis in Pregnant Women: A Systematic Review of Clinical Trials and Observational Studies on Efficacy, Acceptability, Outcomes Measurement Methods, and Studies’ Feasibility

Bolgarina,

Merriam,

Gonzalez-Gonzalez

et al. 2023

Cureus

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“…In addition, patients with disease‐causing variants in some of the genes encoding enzymes of the coenzyme Q10 (CoQ10) pathway (e.g., COQ2 (OMIM 607426) and COQ6 (OMIM 614650)) can be treated using supplementation with CoQ10 (Preston et al, 2019 ). Furthermore, identification of disease‐causing mutations can facilitate the process of kidney donor selection and the prediction of post‐transplant recurrence of NS (Morello et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Genetic analysis and outcomes of Omani children with steroid‐resistant nephrotic syndrome

Al Riyami,

Al Alawi,

Al Gaithi

et al. 2023

Molec Gen & Gen Med

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BackgroundNephrotic syndrome (NS) is one of the most common kidney disorders seen by pediatric nephrologists and is defined by the presence of heavy proteinuria (>3.5 g/24 h), hypoalbuminemia (<3.5 g/dL), edema, and hyperlipidemia. Most children with NS are steroid‐responsive and have a good prognosis following treatment with prednisolone. However, 10%–20% of them have steroid‐resistant nephrotic syndrome (SRNS) and fail to respond to treatment. A significant proportion of these children progress to kidney failure.MethodsThis retrospective study aimed to determine the underlying genetic causes of SRNS among Omani children below 13 years old, over a 15‐year period and included 77 children from 50 different families. We used targeted Sanger sequencing combined with next‐generation sequencing approaches to perform molecular diagnostics.ResultsWe found a high rate of underlying genetic causes of SRNS in 61 (79.2%) children with pathogenic variants in the associated genes. Most of these genetically solved SRNS patients were born to consanguineous parents and variants were in the homozygous state. Pathogenic variants in NPHS2 were the most common cause of SRNS in our study seen in 37 (48.05%) cases. Pathogenic variants in NPHS1 were also seen in 16 cases, especially in infants with congenital nephrotic syndrome (CNS). Other genetic causes identified included pathogenic variants in LAMB2, PLCE1, MYO1E, and NUP93.ConclusionNPHS2 and NPHS1 genetic variants were the most common inherited causes of SRNS in Omani children. However, patients with variants in several other SRNS causative genes were also identified. We recommend screening for all genes responsible for SRNS in all children who present with this phenotype, which will assist in clinical management decisions and genetic counseling for the affected families.

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WT1-related disorders: more than Denys-Drash syndrome

Lopez-Gonzalez,

Ariceta

2024

Pediatr Nephrol

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A Systematic Review and Meta-Analysis of the Rate and Risk Factors for Post-transplant Disease Recurrence in Children With Steroid Resistant Nephrotic Syndrome

Cited by 6 publications

References 29 publications

Cranberry Supplements for Urinary Tract Infection Prophylaxis in Pregnant Women: A Systematic Review of Clinical Trials and Observational Studies on Efficacy, Acceptability, Outcomes Measurement Methods, and Studies’ Feasibility

Cranberry Supplements for Urinary Tract Infection Prophylaxis in Pregnant Women: A Systematic Review of Clinical Trials and Observational Studies on Efficacy, Acceptability, Outcomes Measurement Methods, and Studies’ Feasibility

Genetic analysis and outcomes of Omani children with steroid‐resistant nephrotic syndrome

WT1-related disorders: more than Denys-Drash syndrome

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